In vitro assays of mitochondrial function/dysfunction

Clinical Pharmacology and Therapeutics

Volumn 96, Issue 6, 2014, Pages 665-668

  Than, T A ^a   Win, S ^a   Kaplowitz, N ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID METABOLISM; ANAEROBIC GLYCOLYSIS; ARTICLE; CARBON METABOLISM; CELL FUNCTION; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOSE RESPONSE; ENDOPLASMIC RETICULUM STRESS; GLYCOLYSIS; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; LIVER CELL; LIVER MITOCHONDRION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; METABOLISM; MITOCHONDRION; MOUSE; OXYGEN CONSUMPTION; PHYSIOLOGY; PROCEDURES;

ADENOSINE TRIPHOSPHATE; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARBONYL CYANIDE M-CHLOROPHENYL HYDRAZONE; HEPATOCYTES; HUMANS; IN VITRO TECHNIQUES; MICE; MITOCHONDRIA; OXYGEN CONSUMPTION;

EID: 84925552551     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2014.178     Document Type: Article

References (5)

1. Perry, C.G., Kane, D.A., Lanza, I.R. &Neufer, P.D. Methods for assessing mitochondrial function in diabetes. Diabetes 62, 1041-1053 (2013).
2. Brand, M.D. &Nicholls, D.G. Assessing mitochondrial dysfunction in cells. Biochem. J. 435, 297-312 (2011).
3. Win, S., Than, T.A., Han, D., Petrovic, L.M. &Kaplowitz, N. c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice. J. Biol. Chem. 286, 35071-35078 (2011).
4. Win, S., Than, T.A., Fernandez-Checa, J.C. &Kaplowitz, N. JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death. Cell Death Dis. 5, e989 (2014).
5. Marroquin, L.D., Hynes, J., Dykens, J.A., Jamieson, J.D. &Will, Y. Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants. Toxicol. Sci. 97, 539-547 (2007)