Intracerebroventricular Metformin Decreases Body Weight But Has Pro-oxidant Effects and Decreases Survival

Neurochemical Research

Volumn 40, Issue 3, 2015, Pages 514-523

  Portela, Luis Valmor ^a   Gnoatto, Jussania ^a   Wigner Brochier, Andressa ^a   Haas, Clarissa Branco ^a   de Assis, Adriano Martimbianco ^a   de Carvalho, Afonso Kopczynski ^a   Hansel, Gisele ^a   Rigon Zimmer, Eduardo ^a   Oses, Jean Pierre ^b   Muller, Alexandre Pastoris ^c  

^a Instituto de Ciencias Biologicas e da Saude Pontifical Catholic University of Minas Gerais   (Brazil)

^b CATHOLIC UNIVERSITY OF PELOTAS   (Brazil)

^c UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

Author keywords

Body temperature; Body weight; Brain metabolism; Fat pads; Food intake; Insulin resistance; Mitochondrial function

Indexed keywords

GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; INSULIN; METFORMIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; ANTIDIABETIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BODY MASS; BODY TEMPERATURE; BRAIN METABOLISM; BRAIN MITOCHONDRION; CELL DAMAGE; CONTROLLED STUDY; DRUG DOSE INCREASE; EMBRYO; FOOD INTAKE; GLUCOSE TOLERANCE TEST; HIPPOCAMPUS; HYPOGLYCEMIA; HYPOTHALAMUS; HYPOTHERMIA; INSULIN SENSITIVITY; MALE; METABOLIC STRESS; MOUSE; NERVE CELL CULTURE; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PRIORITY JOURNAL; SURVIVAL RATE; WEIGHT REDUCTION; ANIMAL; BODY WEIGHT; CELL CULTURE; CHEMICALLY INDUCED; DRUG EFFECTS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; MORTALITY; PHYSIOLOGY; RAT; TRENDS; WISTAR RAT;

ANIMALS; BODY WEIGHT; CELLS, CULTURED; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; INFUSIONS, INTRAVENTRICULAR; MALE; METFORMIN; MICE; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SURVIVAL RATE;

EID: 84925511669     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-014-1496-7     Document Type: Article

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