Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 7, 2015, Pages 1635-1642

  Pinto, Donald J P ^a   Smallheer, Joanne M ^a   Corte, James R ^a   Austin, Erin J D ^a   Wang, Cailan ^a   Fang, Tianan ^a   Smith, Leon M ^a   Rossi, Karen A ^a   Rendina, Alan R ^a   Bozarth, Jeffrey M ^a   Zhang, Ge ^a   Wei, Anzhi ^a   Ramamurthy, Vidhyashankar ^a   Sheriff, Steven ^a   Myers, Joseph E ^a   Morin, Paul E ^a   Luettgen, Joseph M ^a   Seiffert, Dietmar A ^a   Quan, Mimi L ^a   Wexler, Ruth R ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Anticoagulant; Bioavailability; Factor; Serine protease; Thrombosis; XIa

Indexed keywords

BLOOD CLOTTING FACTOR 11A; BLOOD CLOTTING FACTOR 11A INHIBITOR; BLOOD CLOTTING INHIBITOR; CHYMOTRYPSIN; PLASMA KALLIKREIN; PLASMIN; THROMBIN; TISSUE KALLIKREIN; TRYPSIN; UNCLASSIFIED DRUG; ENZYME INHIBITOR; INDAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CHLORINATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIASTEREOISOMER; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG CONFORMATION; DRUG DESIGN; DRUG DISTRIBUTION; DRUG IDENTIFICATION; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER MICROSOME; METABOLIC STABILITY; MOLECULAR MODEL; NONHUMAN; PROCESS OPTIMIZATION; PROTEIN BINDING; SAPONIFICATION; VOLUME OF DISTRIBUTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOAVAILABILITY; CHEMICAL STRUCTURE; CHEMISTRY; DOG; DOSE RESPONSE; DRUG EFFECTS; ORAL DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; FACTOR XIA; HUMANS; INDAZOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84925498073     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.01.028     Document Type: Article

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