Enhancing Our Understanding of Current Therapies for Hepatitis C Virus (HCV)

Current HIV/AIDS Reports

Volumn 12, Issue 1, 2015, Pages 68-78

  Gogela, Neliswa A ^a   Lin, Ming V ^a,b,c   Wisocky, Jessica L ^a   Chung, Raymond T ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Direct acting antivirals (DAAs); HCV HIV co infection; NS5A inhibitors; NS5B polymerase inhibitors; Protease inhibitors

Indexed keywords

ANTIVIRUS AGENT; NONSTRUCTURAL PROTEIN 3 INHIBITOR; NONSTRUCTURAL PROTEIN 5A INHIBITOR; NONSTRUCTURAL PROTEIN 5B INHIBITOR; PEGINTERFERON ALPHA; PROTEINASE INHIBITOR; RIBAVIRIN; UNCLASSIFIED DRUG; DRUG COMBINATION;

ANTIVIRAL THERAPY; COMPREHENSION; DRUG APPROVAL; DRUG EFFICACY; DRUG TOLERABILITY; FOOD AND DRUG ADMINISTRATION; HEMODIALYSIS; HEPATITIS C; HEPATITIS C VIRUS; HEPATITIS C VIRUS GENOTYPE 1; HEPATITIS C VIRUS GENOTYPE 2; HEPATITIS C VIRUS GENOTYPE 3; HEPATITIS C VIRUS GENOTYPE 4; HEPATITIS C VIRUS GENOTYPE 5; HEPATITIS C VIRUS GENOTYPE 6; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KIDNEY FAILURE; LIFE CYCLE; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; MIXED INFECTION; NONHUMAN; PHASE 2 CLINICAL TRIAL (TOPIC); POSTOPERATIVE INFECTION; RECURRENT INFECTION; REVIEW; DRUG COMBINATION; HEPACIVIRUS; HEPATITIS C, CHRONIC; PATHOGENICITY;

ANTIVIRAL AGENTS; DRUG COMBINATIONS; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS;

EID: 84925487467     PISSN: 15483568     EISSN: 15483576     Source Type: Journal    
DOI: 10.1007/s11904-014-0243-7     Document Type: Review

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68. 3.All patients on ART were on tenofovir/emtricitabine, 41% were on efavirenz, 27% raltegravir and 21% on rilpivirine. 100% SVR12 rates were observed in the untreated group and 100% SVR4 in the ART group. No adverse events reported thus far.
69. Sulkowski M, E.J., Wyles D, Trinh R, Lalezari J, Slim J, Gathe J, Ruane PJ, Wang C, Elion R, Bredeek F, Brennan R, Blick G, Khatri A, Gibbons K, Hu YB, Fredrick L, Pilot-Matias T, Da Silva-Tillmann, McGovern BB, Campbell AL, Podsadecki T. TURQUOISE-I: safety and efficacy of ABT-450/r/ombitasvir, dasabuvir, and ribavirin in patients co-infected with hepatitis C and HIV-1. International AIDS conference, 2014. TURQUOISE-1: This study has evaluated the safety and efficacy of ABT-450 /r/ombitasvir, dasabuvir and ribavirin in HIV/HCV-1 co-infected individuals. A total number 63 individuals, majority males (92.1 %), white race (76.2), GT1a (88.9 %), 19 % had cirrhosis and a few (33.3 %) were previously treated. SVR 4 for the 12 week arm was 96.8 % and EOTR for the 24 week arms was 96.7 %. No adverse events reported thus far. ART regimen used consisted of atazanavir or raltegravir.
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