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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 7, 2015, Pages 1443-1447

The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders

(22) Bi, Yingzhi a Dzierba, Carolyn D b Fink, Cynthia a Garcia, Yudith a Green, Michael a Han, Jianxin a Kwon, Soojin a Kumi, Godwin a Liang, Zhi a Liu, Ying a Qiao, Ying a Zhang, Yulian a Zipp, Greg a Burford, Neil b Ferrante, Meredith b Bertekap, Robert b Lewis, Martin b Cacace, Angela b Westphal, Ryan S b Kimball, David a more..

a LEXICON PHARMACEUTICALS INC (United States)

b BRISTOL MYERS SQUIBB (United States)

Author keywords

Agonists; CNS; GPC; GPR88; Schizophrenia

Indexed keywords

CENTRAL NERVOUS SYSTEM AGENTS; CYCLOPROPANE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 88; UNCLASSIFIED DRUG; AMIDE; AMINE; GPR88 PROTEIN, HUMAN;

ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CYCLOPROPANATION; DIASTEREOISOMER; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; SCHIZOPHRENIA; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; AGONISTS; CENTRAL NERVOUS SYSTEM DISEASES; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; HUMAN; SYNTHESIS;

AMIDES; AMINES; CENTRAL NERVOUS SYSTEM DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84925486258 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.02.038 Document Type: Article

Times cited : (19)

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