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Volumn 36, Issue 2, 2015, Pages 1003-1013

Performance comparison of three BRAF V600E detection methods in malignant melanoma and colorectal cancer specimens

Author keywords

BRAF mutations; Colorectal cancer; Detection methods; Immunohistochemistry; Malignant melanoma

Indexed keywords

B RAF KINASE; GENOMIC DNA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY VE1; UNCLASSIFIED DRUG; BRAF PROTEIN, HUMAN; TUMOR MARKER;

EID: 84925483472     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-2711-5     Document Type: Article
Times cited : (22)

References (32)
  • 1
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • COI: 1:CAS:528:DC%2BC3MXosVeitbs%3D, PID: 21639808
    • Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364:2507–16.
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3    Haanen, J.B.4    Ascierto, P.5    Larkin, J.6
  • 2
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
    • COI: 1:CAS:528:DC%2BC38Xpt1SgtLg%3D, PID: 22735384
    • Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M, et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet. 2012;380:358–65.
    • (2012) Lancet , vol.380 , pp. 358-365
    • Hauschild, A.1    Grob, J.J.2    Demidov, L.V.3    Jouary, T.4    Gutzmer, R.5    Millward, M.6
  • 3
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
    • PID: 20619739
    • De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, Fountzilas G, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol. 2010;11:753–62.
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3    De Schutter, J.4    Biesmans, B.5    Fountzilas, G.6
  • 4
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • PID: 19001320
    • Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol. 2008;26:5705–12.
    • (2008) J Clin Oncol , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3    Sartore-Bianchi, A.4    Arena, S.5    Saletti, P.6
  • 5
    • 84856512550 scopus 로고    scopus 로고
    • Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803
    • COI: 1:CAS:528:DC%2BC38XhslOrsrw%3D, PID: 22147942
    • Ogino S, Shima K, Meyerhardt JA, McCleary NJ, Ng K, Hollis D, et al. Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803. Clin Cancer Res. 2012;18:890–900.
    • (2012) Clin Cancer Res , vol.18 , pp. 890-900
    • Ogino, S.1    Shima, K.2    Meyerhardt, J.A.3    McCleary, N.J.4    Ng, K.5    Hollis, D.6
  • 6
    • 34547405167 scopus 로고    scopus 로고
    • Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer
    • COI: 1:STN:280:DC%2BD2svjsVCnsQ%3D%3D, PID: 17453358
    • Loughrey MB, Waring PM, Tan A, Trivett M, Kovalenko S, Beshay V, et al. Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer. Fam Cancer. 2007;6:301–10.
    • (2007) Fam Cancer , vol.6 , pp. 301-310
    • Loughrey, M.B.1    Waring, P.M.2    Tan, A.3    Trivett, M.4    Kovalenko, S.5    Beshay, V.6
  • 7
    • 84880265173 scopus 로고    scopus 로고
    • BRAF V600E-specific immunohistochemistry for the exclusion of lynch syndrome in MSI-H colorectal cancer
    • Capper D, Voigt A, Bozukova G, Ahadova A, Kickingereder P, von Deimling A, et al. BRAF V600E-specific immunohistochemistry for the exclusion of lynch syndrome in MSI-H colorectal cancer. Int J Cancer. 2013;133:1624–30.
    • (2013) Int J Cancer , vol.133 , pp. 1624-1630
    • Capper, D.1    Voigt, A.2    Bozukova, G.3    Ahadova, A.4    Kickingereder, P.5    von Deimling, A.6
  • 8
    • 84875410796 scopus 로고    scopus 로고
    • Detection of BRAF p.V600E mutations in melanomas: comparison of four methods argues for sequential use of immunohistochemistry and pyrosequencing
    • COI: 1:CAS:528:DC%2BC3sXhs1elt7o%3D, PID: 23159108
    • Colomba E, Helias-Rodzewicz Z, Von Deimling A, Marin C, Terrones N, Pechaud D, et al. Detection of BRAF p.V600E mutations in melanomas: comparison of four methods argues for sequential use of immunohistochemistry and pyrosequencing. J Mol Diagn. 2013;15:94–100.
    • (2013) J Mol Diagn , vol.15 , pp. 94-100
    • Colomba, E.1    Helias-Rodzewicz, Z.2    Von Deimling, A.3    Marin, C.4    Terrones, N.5    Pechaud, D.6
  • 9
    • 79959580390 scopus 로고    scopus 로고
    • Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody
    • COI: 1:CAS:528:DC%2BC3MXnvVKnsr0%3D, PID: 21638088
    • Capper D, Preusser M, Habel A, Sahm F, Ackermann U, Schindler G, et al. Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody. Acta Neuropathol. 2011;122:11–9.
    • (2011) Acta Neuropathol , vol.122 , pp. 11-19
    • Capper, D.1    Preusser, M.2    Habel, A.3    Sahm, F.4    Ackermann, U.5    Schindler, G.6
  • 10
    • 84873715417 scopus 로고    scopus 로고
    • Detection of the BRAF V600E mutation in serous ovarian tumors: a comparative analysis of immunohistochemistry with a mutation-specific monoclonal antibody and allele-specific PCR
    • PID: 23089489
    • Bosmuller H, Fischer A, Pham DL, Fehm T, Capper D, von Deimling A, et al. Detection of the BRAF V600E mutation in serous ovarian tumors: a comparative analysis of immunohistochemistry with a mutation-specific monoclonal antibody and allele-specific PCR. Hum Pathol. 2013;44:329–35.
    • (2013) Hum Pathol , vol.44 , pp. 329-335
    • Bosmuller, H.1    Fischer, A.2    Pham, D.L.3    Fehm, T.4    Capper, D.5    von Deimling, A.6
  • 11
    • 84857030136 scopus 로고    scopus 로고
    • Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastases
    • COI: 1:CAS:528:DC%2BC38XpslyktA%3D%3D, PID: 22012135
    • Capper D, Berghoff AS, Magerle M, Ilhan A, Wohrer A, Hackl M, et al. Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastases. Acta Neuropathol. 2012;123:223–33.
    • (2012) Acta Neuropathol , vol.123 , pp. 223-233
    • Capper, D.1    Berghoff, A.S.2    Magerle, M.3    Ilhan, A.4    Wohrer, A.5    Hackl, M.6
  • 12
    • 84862109270 scopus 로고    scopus 로고
    • Immunohistochemical detection of the BRAF V600E-mutated protein in papillary thyroid carcinoma
    • PID: 22592144
    • Koperek O, Kornauth C, Capper D, Berghoff AS, Asari R, Niederle B, et al. Immunohistochemical detection of the BRAF V600E-mutated protein in papillary thyroid carcinoma. Am J Surg Pathol. 2012;36:844–50.
    • (2012) Am J Surg Pathol , vol.36 , pp. 844-850
    • Koperek, O.1    Kornauth, C.2    Capper, D.3    Berghoff, A.S.4    Asari, R.5    Niederle, B.6
  • 13
    • 84871619722 scopus 로고    scopus 로고
    • Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma
    • PID: 23026937
    • Long GV, Wilmott JS, Capper D, Preusser M, Zhang YE, Thompson JF, et al. Immunohistochemistry is highly sensitive and specific for the detection of V600E BRAF mutation in melanoma. Am J Surg Pathol. 2013;37:61–5.
    • (2013) Am J Surg Pathol , vol.37 , pp. 61-65
    • Long, G.V.1    Wilmott, J.S.2    Capper, D.3    Preusser, M.4    Zhang, Y.E.5    Thompson, J.F.6
  • 14
    • 84880572740 scopus 로고    scopus 로고
    • Mutation-specific antibody detects mutant BRAF (V600E) protein expression in human colon carcinomas
    • COI: 1:CAS:528:DC%2BC3sXhtFGmt77M, PID: 23657789
    • Sinicrope FA, Smyrk TC, Tougeron D, Thibodeau SN, Singh S, Muranyi A, et al. Mutation-specific antibody detects mutant BRAF (V600E) protein expression in human colon carcinomas. Cancer. 2013;119:2765–70.
    • (2013) Cancer , vol.119 , pp. 2765-2770
    • Sinicrope, F.A.1    Smyrk, T.C.2    Tougeron, D.3    Thibodeau, S.N.4    Singh, S.5    Muranyi, A.6
  • 15
    • 84888994058 scopus 로고    scopus 로고
    • Ultra-deep sequencing confirms immunohistochemistry as a highly sensitive and specific method for detecting BRAF V600E mutations in colorectal carcinoma
    • COI: 1:CAS:528:DC%2BC3sXhsFOgu7vE
    • Rossle M, Sigg M, Ruschoff JH, Wild PJ, Moch H, Weber A, et al. Ultra-deep sequencing confirms immunohistochemistry as a highly sensitive and specific method for detecting BRAF V600E mutations in colorectal carcinoma. Virchows Archiv Int J Pathol. 2013;463:623–31.
    • (2013) Virchows Archiv Int J Pathol , vol.463 , pp. 623-631
    • Rossle, M.1    Sigg, M.2    Ruschoff, J.H.3    Wild, P.J.4    Moch, H.5    Weber, A.6
  • 16
    • 84879254737 scopus 로고    scopus 로고
    • BRAF V600E mutation detection by immunohistochemistry in colorectal carcinoma
    • COI: 1:CAS:528:DC%2BC3sXntV2ku7s%3D, PID: 23650027
    • Affolter K, Samowitz W, Tripp S, Bronner MP. BRAF V600E mutation detection by immunohistochemistry in colorectal carcinoma. Genes Chromosomes Cancer. 2013;52:748–52.
    • (2013) Genes Chromosomes Cancer , vol.52 , pp. 748-752
    • Affolter, K.1    Samowitz, W.2    Tripp, S.3    Bronner, M.P.4
  • 17
    • 84880725363 scopus 로고    scopus 로고
    • Immunohistochemistry using the BRAF V600E mutation-specific monoclonal antibody VE1 is not a useful surrogate for genotyping in colorectal adenocarcinoma
    • PID: 23763264
    • Adackapara CA, Sholl LM, Barletta JA, Hornick JL. Immunohistochemistry using the BRAF V600E mutation-specific monoclonal antibody VE1 is not a useful surrogate for genotyping in colorectal adenocarcinoma. Histopathology. 2013;63:187–93.
    • (2013) Histopathology , vol.63 , pp. 187-193
    • Adackapara, C.A.1    Sholl, L.M.2    Barletta, J.A.3    Hornick, J.L.4
  • 18
    • 82755162722 scopus 로고    scopus 로고
    • Comparison of allelic discrimination by dHPLC, HRM, and Taqman in the detection of BRAF mutation V600E
    • COI: 1:CAS:528:DC%2BC3MXht1CltrfJ, PID: 21708284
    • Carbonell P, Turpin MC, Torres-Moreno D, Molina-Martinez I, Garcia-Solano J, Perez-Guillermo M, et al. Comparison of allelic discrimination by dHPLC, HRM, and Taqman in the detection of BRAF mutation V600E. J Mol Diagn. 2011;13:467–73.
    • (2011) J Mol Diagn , vol.13 , pp. 467-473
    • Carbonell, P.1    Turpin, M.C.2    Torres-Moreno, D.3    Molina-Martinez, I.4    Garcia-Solano, J.5    Perez-Guillermo, M.6
  • 19
    • 84867555830 scopus 로고    scopus 로고
    • Multisite analytic performance studies of a real-time polymerase chain reaction assay for the detection of BRAF V600E mutations in formalin-fixed paraffin-embedded tissue specimens of malignant melanoma
    • COI: 1:CAS:528:DC%2BC38XhvV2nsbrM, PID: 22332713
    • Anderson S, Bloom KJ, Vallera DU, Rueschoff J, Meldrum C, Schilling R, et al. Multisite analytic performance studies of a real-time polymerase chain reaction assay for the detection of BRAF V600E mutations in formalin-fixed paraffin-embedded tissue specimens of malignant melanoma. Arch Pathol Lab Med. 2012;136:1385–91.
    • (2012) Arch Pathol Lab Med , vol.136 , pp. 1385-1391
    • Anderson, S.1    Bloom, K.J.2    Vallera, D.U.3    Rueschoff, J.4    Meldrum, C.5    Schilling, R.6
  • 20
    • 84857232726 scopus 로고    scopus 로고
    • Analytical performance of a real-time pcr-based assay for V600 mutations in the BRAF gene, used as the companion diagnostic test for the novel BRAF inhibitor vemurafenib in metastatic melanoma
    • COI: 1:CAS:528:DC%2BC38XitFagtLg%3D
    • Halait H, Demartin K, Shah S, Soviero S, Langland R, Cheng S, et al. Analytical performance of a real-time pcr-based assay for V600 mutations in the BRAF gene, used as the companion diagnostic test for the novel BRAF inhibitor vemurafenib in metastatic melanoma. Diagn Mol Pathol Am J Surg Pathol B. 2012;21:1–8.
    • (2012) Diagn Mol Pathol Am J Surg Pathol B , vol.21 , pp. 1-8
    • Halait, H.1    Demartin, K.2    Shah, S.3    Soviero, S.4    Langland, R.5    Cheng, S.6
  • 21
    • 48649092117 scopus 로고    scopus 로고
    • High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer
    • COI: 1:CAS:528:DC%2BD1cXhtVegtbnM, PID: 18628094
    • Simi L, Pratesi N, Vignoli M, Sestini R, Cianchi F, Valanzano R, et al. High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer. Am J Clin Pathol. 2008;130:247–53.
    • (2008) Am J Clin Pathol , vol.130 , pp. 247-253
    • Simi, L.1    Pratesi, N.2    Vignoli, M.3    Sestini, R.4    Cianchi, F.5    Valanzano, R.6
  • 22
    • 84872257074 scopus 로고    scopus 로고
    • Comparison of testing methods for the detection of BRAF V600E mutations in malignant melanoma: pre-approval validation study of the companion diagnostic test for vemurafenib
    • COI: 1:CAS:528:DC%2BC3sXhtlGisr4%3D, PID: 23326492
    • Lopez-Rios F, Angulo B, Gomez B, Mair D, Martinez R, Conde E, et al. Comparison of testing methods for the detection of BRAF V600E mutations in malignant melanoma: pre-approval validation study of the companion diagnostic test for vemurafenib. PLoS One. 2013;8:e53733.
    • (2013) PLoS One , vol.8 , pp. e53733
    • Lopez-Rios, F.1    Angulo, B.2    Gomez, B.3    Mair, D.4    Martinez, R.5    Conde, E.6
  • 23
    • 84892377126 scopus 로고    scopus 로고
    • Comparison of high resolution melting analysis, pyrosequencing, next generation sequencing and immunohistochemistry to conventional Sanger sequencing for the detection of p.V600E and non-p.V600E BRAF mutations
    • PID: 24410877
    • Ihle MA, Fassunke J, Konig K, Grunewald I, Schlaak M, Kreuzberg N, et al. Comparison of high resolution melting analysis, pyrosequencing, next generation sequencing and immunohistochemistry to conventional Sanger sequencing for the detection of p.V600E and non-p.V600E BRAF mutations. BMC Cancer. 2014;14:13.
    • (2014) BMC Cancer , vol.14 , pp. 13
    • Ihle, M.A.1    Fassunke, J.2    Konig, K.3    Grunewald, I.4    Schlaak, M.5    Kreuzberg, N.6
  • 24
    • 77954234849 scopus 로고    scopus 로고
    • Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome
    • PID: 20460471
    • Jonsson G, Busch C, Knappskog S, Geisler J, Miletic H, Ringner M, et al. Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome. Clin Cancer Res. 2010;16:3356–67.
    • (2010) Clin Cancer Res , vol.16 , pp. 3356-3367
    • Jonsson, G.1    Busch, C.2    Knappskog, S.3    Geisler, J.4    Miletic, H.5    Ringner, M.6
  • 25
    • 40849094167 scopus 로고    scopus 로고
    • Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site
    • PID: 19383313
    • Platz A, Egyhazi S, Ringborg U, Hansson J. Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site. Mol Oncol. 2008;1:395–405.
    • (2008) Mol Oncol , vol.1 , pp. 395-405
    • Platz, A.1    Egyhazi, S.2    Ringborg, U.3    Hansson, J.4
  • 26
    • 84890429134 scopus 로고    scopus 로고
    • Low BRAF and NRAS expression levels are associated with clinical benefit from DTIC therapy and prognosis in metastatic melanoma
    • COI: 1:CAS:528:DC%2BC3sXhvVehsb%2FP, PID: 23673558
    • Birkeland E, Busch C, Berge EO, Geisler J, Jonsson G, Lillehaug JR, et al. Low BRAF and NRAS expression levels are associated with clinical benefit from DTIC therapy and prognosis in metastatic melanoma. Clin Exp Metastasis. 2013;30:867–76.
    • (2013) Clin Exp Metastasis , vol.30 , pp. 867-876
    • Birkeland, E.1    Busch, C.2    Berge, E.O.3    Geisler, J.4    Jonsson, G.5    Lillehaug, J.R.6
  • 27
    • 80052273582 scopus 로고    scopus 로고
    • Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma
    • COI: 1:CAS:528:DC%2BC3MXhtFSjsb%2FJ, PID: 21190184
    • Eisenhardt AE, Olbrich H, Roring M, Janzarik W, Anh TN, Cin H, et al. Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma. Int J Cancer. 2011;129:2297–303.
    • (2011) Int J Cancer , vol.129 , pp. 2297-2303
    • Eisenhardt, A.E.1    Olbrich, H.2    Roring, M.3    Janzarik, W.4    Anh, T.N.5    Cin, H.6
  • 28
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • COI: 1:CAS:528:DC%2BD38XkvVagsLo%3D, PID: 12068308
    • Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417:949–54.
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3    Stephens, P.4    Edkins, S.5    Clegg, S.6
  • 29
    • 84885672683 scopus 로고    scopus 로고
    • A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma
    • PID: 23584600
    • Richter A, Grieu F, Carrello A, Amanuel B, Namdarian K, Rynska A, et al. A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma. Sci Rep. 2013;3:1659.
    • (2013) Sci Rep , vol.3 , pp. 1659
    • Richter, A.1    Grieu, F.2    Carrello, A.3    Amanuel, B.4    Namdarian, K.5    Rynska, A.6
  • 30
    • 12144289677 scopus 로고    scopus 로고
    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    • COI: 1:CAS:528:DC%2BD2cXivVyksLw%3D, PID: 15035987
    • Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell. 2004;116:855–67.
    • (2004) Cell , vol.116 , pp. 855-867
    • Wan, P.T.1    Garnett, M.J.2    Roe, S.M.3    Lee, S.4    Niculescu-Duvaz, D.5    Good, V.M.6
  • 31
    • 75749102647 scopus 로고    scopus 로고
    • Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60–00 trial
    • COI: 1:CAS:528:DC%2BC3cXivFartb4%3D, PID: 20008640
    • Roth AD, Tejpar S, Delorenzi M, Yan P, Fiocca R, Klingbiel D, et al. Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60–00 trial. J Clin Oncol. 2010;28:466–74.
    • (2010) J Clin Oncol , vol.28 , pp. 466-474
    • Roth, A.D.1    Tejpar, S.2    Delorenzi, M.3    Yan, P.4    Fiocca, R.5    Klingbiel, D.6
  • 32
    • 84888002049 scopus 로고    scopus 로고
    • Incidence and prognostic impact of KRAS and BRAF mutation in patients undergoing liver surgery for colorectal metastases
    • COI: 1:CAS:528:DC%2BC3sXhvVSht7rL, PID: 24104864
    • Karagkounis G, Torbenson MS, Daniel HD, Azad NS, Diaz Jr LA, Donehower RC, et al. Incidence and prognostic impact of KRAS and BRAF mutation in patients undergoing liver surgery for colorectal metastases. Cancer. 2013;119:4137–44.
    • (2013) Cancer , vol.119 , pp. 4137-4144
    • Karagkounis, G.1    Torbenson, M.S.2    Daniel, H.D.3    Azad, N.S.4    Diaz, L.A.5    Donehower, R.C.6


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