A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1

Diabetologia

Volumn 58, Issue 4, 2015, Pages 745-748

  Locke, Jonathan M ^a   Wei, Fan Yan ^b   Tomizawa, Kazuhito ^b   Weedon, Michael N ^a   Harries, Lorna W ^a  

^a UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

CDKAL1; Expression quantitative trait loci; Genome wide association studies; Non coding RNA; Type 2 diabetes

Indexed keywords

CDKAL1 V1; SERINE ARGININE RICH PROTEIN; UNCLASSIFIED DRUG; UNTRANSLATED RNA; CDKAL1 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE 5;

ALLELE; ARTICLE; BINDING SITE; BLOOD SAMPLING; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; JAPANESE (PEOPLE); NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; RNA EXTRACTION; SINGLE NUCLEOTIDE POLYMORPHISM; BLOOD; CASE CONTROL STUDY; CAUCASIAN; CHEMISTRY; DIABETES MELLITUS, TYPE 2; EPIDEMIOLOGY; ETHNOLOGY; GENETIC PREDISPOSITION; GENETICS; INTRON; PHENOTYPE; STATISTICAL MODEL; UNITED KINGDOM;

CASE-CONTROL STUDIES; CYCLIN-DEPENDENT KINASE 5; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GREAT BRITAIN; HUMANS; INTRONS; ISLETS OF LANGERHANS; LINEAR MODELS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; RNA, UNTRANSLATED;

EID: 84925482810     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3508-9     Document Type: Article

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