메뉴 건너뛰기




Volumn 12, Issue 1, 2015, Pages 33-40

T Memory Stem Cells and HIV: a Long-Term Relationship

Author keywords

Central memory; Effector memory; HIV; HIV 1 reservoir; Memory T cell; Persistence; SIV; Stem cell; T memory stem cell; Catenin

Indexed keywords

CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGICAL MEMORY; LONG TERM CARE; MEMORY T LYMPHOCYTE; NONHUMAN; PATHOGENESIS; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UBIQUITINATION; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; PHYSIOLOGY; STEM CELL; T LYMPHOCYTE SUBPOPULATION; VIRAL TROPISM; VIROLOGY;

EID: 84925467325     PISSN: 15483568     EISSN: 15483576     Source Type: Journal    
DOI: 10.1007/s11904-014-0246-4     Document Type: Review
Times cited : (46)

References (62)
  • 1
    • 2342584151 scopus 로고    scopus 로고
    • Immunological memory in humans
    • COI: 1:CAS:528:DC%2BD2cXjvVemtro%3D, PID: 15130504
    • Crotty S, Ahmed R. Immunological memory in humans. Semin Immunol. 2004;16:197–203.
    • (2004) Semin Immunol , vol.16 , pp. 197-203
    • Crotty, S.1    Ahmed, R.2
  • 2
    • 84898019055 scopus 로고    scopus 로고
    • Lineage relationship of effector and memory T cells
    • COI: 1:CAS:528:DC%2BC3sXhs12lsLfP, PID: 24148236
    • Restifo NP, Gattinoni L. Lineage relationship of effector and memory T cells. Curr Opin Immunol. 2013;25:556–63.
    • (2013) Curr Opin Immunol , vol.25 , pp. 556-563
    • Restifo, N.P.1    Gattinoni, L.2
  • 3
    • 2142730100 scopus 로고    scopus 로고
    • Central memory and effector memory T cell subsets: function, generation, and maintenance
    • COI: 1:CAS:528:DC%2BD2cXktlOgsb8%3D, PID: 15032595
    • Sallusto F, Geginat J, Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol. 2004;22:745–63.
    • (2004) Annu Rev Immunol , vol.22 , pp. 745-763
    • Sallusto, F.1    Geginat, J.2    Lanzavecchia, A.3
  • 4
    • 0035937587 scopus 로고    scopus 로고
    • Preferential localization of effector memory cells in nonlymphoid tissue
    • COI: 1:CAS:528:DC%2BD3MXit1Kms70%3D, PID: 11264538
    • Masopust D, Vezys V, Marzo AL, Lefrancois L. Preferential localization of effector memory cells in nonlymphoid tissue. Science. 2001;291:2413–7.
    • (2001) Science , vol.291 , pp. 2413-2417
    • Masopust, D.1    Vezys, V.2    Marzo, A.L.3    Lefrancois, L.4
  • 5
    • 0035282433 scopus 로고    scopus 로고
    • Visualizing the generation of memory CD4 T cells in the whole body
    • COI: 1:CAS:528:DC%2BD3MXhvVSmtb8%3D, PID: 11242050
    • Reinhardt RL, Khoruts A, Merica R, Zell T, Jenkins MK. Visualizing the generation of memory CD4 T cells in the whole body. Nature. 2001;410:101–5.
    • (2001) Nature , vol.410 , pp. 101-105
    • Reinhardt, R.L.1    Khoruts, A.2    Merica, R.3    Zell, T.4    Jenkins, M.K.5
  • 6
    • 84893710050 scopus 로고    scopus 로고
    • Human memory T cells: generation, compartmentalization and homeostasis
    • COI: 1:CAS:528:DC%2BC3sXhvFart7rF, PID: 24336101
    • Farber DL, Yudanin NA, Restifo NP. Human memory T cells: generation, compartmentalization and homeostasis. Nat Rev Immunol. 2014;14:24–35.
    • (2014) Nat Rev Immunol , vol.14 , pp. 24-35
    • Farber, D.L.1    Yudanin, N.A.2    Restifo, N.P.3
  • 7
    • 84866735170 scopus 로고    scopus 로고
    • Paths to stemness: building the ultimate antitumour T cell
    • COI: 1:CAS:528:DC%2BC38XhtlyltLfI, PID: 22996603
    • Gattinoni L, Klebanoff CA, Restifo NP. Paths to stemness: building the ultimate antitumour T cell. Nat Rev Cancer. 2012;12:671–84.
    • (2012) Nat Rev Cancer , vol.12 , pp. 671-684
    • Gattinoni, L.1    Klebanoff, C.A.2    Restifo, N.P.3
  • 8
    • 70449474686 scopus 로고    scopus 로고
    • A distinct subset of self-renewing human memory CD8+ T cells survives cytotoxic chemotherapy
    • COI: 1:CAS:528:DC%2BD1MXhsFylsbjF, PID: 19879163
    • Turtle CJ, Swanson HM, Fujii N, Estey EH, Riddell SR. A distinct subset of self-renewing human memory CD8+ T cells survives cytotoxic chemotherapy. Immunity. 2009;31:834–44.
    • (2009) Immunity , vol.31 , pp. 834-844
    • Turtle, C.J.1    Swanson, H.M.2    Fujii, N.3    Estey, E.H.4    Riddell, S.R.5
  • 9
    • 62049085970 scopus 로고    scopus 로고
    • Stem cell-like plasticity of naive and distinct memory CD8+ T cell subsets
    • COI: 1:CAS:528:DC%2BD1MXjsVOjs7k%3D, PID: 19269852
    • Stemberger C et al. Stem cell-like plasticity of naive and distinct memory CD8+ T cell subsets. Semin Immunol. 2009;21:62–8.
    • (2009) Semin Immunol , vol.21 , pp. 62-68
    • Stemberger, C.1
  • 10
    • 80355136633 scopus 로고    scopus 로고
    • T cell memory: the stem of T cell memory
    • COI: 1:CAS:528:DC%2BC3MXhtlGks7fO, PID: 22025045
    • Papatriantafyllou M. T cell memory: the stem of T cell memory. Nat Rev Immunol. 2011;11:716.
    • (2011) Nat Rev Immunol , vol.11 , pp. 716
    • Papatriantafyllou, M.1
  • 11
    • 70249110419 scopus 로고    scopus 로고
    • The precursors of memory: models and controversies
    • COI: 1:CAS:528:DC%2BD1MXpvFCqsr4%3D, PID: 19680250
    • Ahmed R, Bevan MJ, Reiner SL, Fearon DT. The precursors of memory: models and controversies. Nat Rev Immunol. 2009;9:662–8.
    • (2009) Nat Rev Immunol , vol.9 , pp. 662-668
    • Ahmed, R.1    Bevan, M.J.2    Reiner, S.L.3    Fearon, D.T.4
  • 12
    • 80053997259 scopus 로고    scopus 로고
    • A human memory T cell subset with stem cell-like properties
    • COI: 1:CAS:528:DC%2BC3MXhtFyls7bJ, PID: 21926977
    • Gattinoni L et al. A human memory T cell subset with stem cell-like properties. Nat Med. 2011;17:1290–7.
    • (2011) Nat Med , vol.17 , pp. 1290-1297
    • Gattinoni, L.1
  • 13
    • 67650465237 scopus 로고    scopus 로고
    • Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
    • COI: 1:CAS:528:DC%2BD1MXnt1ShsbY%3D, PID: 19525962
    • Gattinoni L et al. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nat Med. 2009;15:808–13.
    • (2009) Nat Med , vol.15 , pp. 808-813
    • Gattinoni, L.1
  • 14
    • 84873395620 scopus 로고    scopus 로고
    • Lugli E, et al. Superior T memory stem cell persistence supports long-lived T cell memory. J Clin Invest. 2013;123:594–9. This is the first article to describe CD8+ and CD4+ T
    • SCMcells in nonhuman primates.
  • 15
    • 28644437672 scopus 로고    scopus 로고
    • Host-reactive CD8+ memory stem cells in graft-versus-host disease
    • COI: 1:CAS:528:DC%2BD2MXht1yisr3L, PID: 16288282
    • Zhang Y, Joe G, Hexner E, Zhu J, Emerson SG. Host-reactive CD8+ memory stem cells in graft-versus-host disease. Nat Med. 2005;11:1299–305.
    • (2005) Nat Med , vol.11 , pp. 1299-1305
    • Zhang, Y.1    Joe, G.2    Hexner, E.3    Zhu, J.4    Emerson, S.G.5
  • 16
    • 84893761231 scopus 로고    scopus 로고
    • SCMcells for long-term HIV-1 persistence in HIV-1-infected individuals treated with suppressive ART
    • SCMcells for long-term HIV-1 persistence in HIV-1-infected individuals treated with suppressive ART.
  • 17
    • 84901255278 scopus 로고    scopus 로고
    • Cartwright EK, et al. Divergent CD4+ T memory stem cell dynamics in pathogenic and nonpathogenic simian immunodeficiency virus infections. J Immunol. 2014;192:4666–73. Here the authors provide the first evidence for a role of CD4+ T
    • SCMcells are preferentially spared from SIV infection in the natural host sooty mangabeys.
  • 18
    • 84923336609 scopus 로고    scopus 로고
    • Jaafoura S, et al. Progressive contraction of the latent HIV reservoir around a core of less-differentiated CD4(+) memory T cells. Nat Commun. 2014;5:5407. This work independently confirmed the contribution of CD4+ T
    • SCMcells to the long-term HIV-1 reservoir.
  • 19
    • 84872032105 scopus 로고    scopus 로고
    • Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells
    • PID: 23222456
    • Lugli E et al. Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells. Nat Protoc. 2012;8:33–42.
    • (2012) Nat Protoc , vol.8 , pp. 33-42
    • Lugli, E.1
  • 20
    • 84255215452 scopus 로고    scopus 로고
    • Th17 cells are long lived and retain a stem cell-like molecular signature
    • COI: 1:CAS:528:DC%2BC3MXhs1Krt77M, PID: 22177921
    • Muranski P et al. Th17 cells are long lived and retain a stem cell-like molecular signature. Immunity. 2011;35:972–85.
    • (2011) Immunity , vol.35 , pp. 972-985
    • Muranski, P.1
  • 21
    • 84904394259 scopus 로고    scopus 로고
    • Serial transfer of single-cell-derived immunocompetence reveals stemness of CD8(+) central memory T cells
    • COI: 1:CAS:528:DC%2BC2cXhtFOrsLvI, PID: 25035956
    • Graef P et al. Serial transfer of single-cell-derived immunocompetence reveals stemness of CD8(+) central memory T cells. Immunity. 2014;41:116–26.
    • (2014) Immunity , vol.41 , pp. 116-126
    • Graef, P.1
  • 22
    • 84873050511 scopus 로고    scopus 로고
    • IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors
    • COI: 1:CAS:528:DC%2BC3sXhvFOnsbo%3D, PID: 23160470
    • Cieri N et al. IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors. Blood. 2013;121:573–84.
    • (2013) Blood , vol.121 , pp. 573-584
    • Cieri, N.1
  • 23
    • 84911401178 scopus 로고    scopus 로고
    • The CD8+ memory stem T cell (TSCM) subset is associated with improved prognosis in chronic HIV-1 infection
    • COI: 1:CAS:528:DC%2BC2cXitV2itbvO, PID: 25253339
    • Ribeiro SP et al. The CD8+ memory stem T cell (TSCM) subset is associated with improved prognosis in chronic HIV-1 infection. J Virol. 2014;88:13836–44.
    • (2014) J Virol , vol.88 , pp. 13836-13844
    • Ribeiro, S.P.1
  • 24
    • 84864020166 scopus 로고    scopus 로고
    • Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses
    • Ndhlovu ZM et al. Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses. J Virol. 2012;86:6959–69.
    • (2012) J Virol , vol.86 , pp. 6959-6969
    • Ndhlovu, Z.M.1
  • 25
    • 84934925089 scopus 로고    scopus 로고
    • Differences in coreceptor specificity contribute to alternative tropism of HIV-1 subtype C for CD4+ T-cell subsets, including stem cell memory T-cells
    • PID: 25387392
    • Cashin K et al. Differences in coreceptor specificity contribute to alternative tropism of HIV-1 subtype C for CD4+ T-cell subsets, including stem cell memory T-cells. Retrovirology. 2014;11:97.
    • (2014) Retrovirology , vol.11 , pp. 97
    • Cashin, K.1
  • 26
    • 84893924855 scopus 로고    scopus 로고
    • Quantifying susceptibility of CD4+ stem memory T-cells to infection by laboratory adapted and clinical HIV-1 strains
    • COI: 1:CAS:528:DC%2BC2MXjtlOqtb0%3D, PID: 24517971
    • Flynn JK et al. Quantifying susceptibility of CD4+ stem memory T-cells to infection by laboratory adapted and clinical HIV-1 strains. Viruses. 2014;6:709–26.
    • (2014) Viruses , vol.6 , pp. 709-726
    • Flynn, J.K.1
  • 27
    • 84897503749 scopus 로고    scopus 로고
    • CD4+ memory stem cells are infected by HIV-1 in a manner regulated in part by SAMHD1 expression
    • PID: 24554663
    • Tabler CO et al. CD4+ memory stem cells are infected by HIV-1 in a manner regulated in part by SAMHD1 expression. J Virol. 2014;88:4976–86.
    • (2014) J Virol , vol.88 , pp. 4976-4986
    • Tabler, C.O.1
  • 28
    • 84911005050 scopus 로고    scopus 로고
    • Buzon MJ, et al. Long-term antiretroviral treatment initiated in primary HIV-1 infection affects the size, composition and decay kinetics of the reservoir of HIV-1 infected CD4 T cells. J Virol. 2014;88:10056–65. These authors show that early initiation of ART results in a smaller overall HIV-1 reservoir in CD4+ T
    • SCMcells.
  • 29
    • 79551578453 scopus 로고    scopus 로고
    • Early events in sexual transmission of HIV and SIV and opportunities for interventions
    • COI: 1:CAS:528:DC%2BC3MXivVWht7k%3D, PID: 21054171
    • Haase AT. Early events in sexual transmission of HIV and SIV and opportunities for interventions. Annu Rev Med. 2011;62:127–39.
    • (2011) Annu Rev Med , vol.62 , pp. 127-139
    • Haase, A.T.1
  • 30
    • 56649095805 scopus 로고    scopus 로고
    • Relevance of studying T cell responses in SIV-infected rhesus macaques
    • COI: 1:CAS:528:DC%2BD1cXhsVGgtrrF, PID: 18964016
    • Valentine LE, Watkins DI. Relevance of studying T cell responses in SIV-infected rhesus macaques. Trends Microbiol. 2008;16:605–11.
    • (2008) Trends Microbiol , vol.16 , pp. 605-611
    • Valentine, L.E.1    Watkins, D.I.2
  • 31
    • 79960011656 scopus 로고    scopus 로고
    • Immunodeficiency lentiviral infections in natural and non-natural hosts
    • COI: 1:CAS:528:DC%2BC3MXhtVWlsbbJ, PID: 21505193
    • Brenchley JM, Paiardini M. Immunodeficiency lentiviral infections in natural and non-natural hosts. Blood. 2011;118:847–54.
    • (2011) Blood , vol.118 , pp. 847-854
    • Brenchley, J.M.1    Paiardini, M.2
  • 32
    • 36048989052 scopus 로고    scopus 로고
    • Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulence
    • COI: 1:CAS:528:DC%2BD2sXpt1Smsbw%3D, PID: 17709518
    • Pandrea IV et al. Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulence. J Immunol. 2007;179:3035–46.
    • (2007) J Immunol , vol.179 , pp. 3035-3046
    • Pandrea, I.V.1
  • 33
    • 84905565097 scopus 로고    scopus 로고
    • Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
    • COI: 1:CAS:528:DC%2BC2cXht12ms77F, PID: 25042999
    • Whitney JB et al. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature. 2014;512:74–7.
    • (2014) Nature , vol.512 , pp. 74-77
    • Whitney, J.B.1
  • 35
    • 33846884633 scopus 로고    scopus 로고
    • Paucity of CD4+ CCR5+ T cells is a typical feature of natural SIV hosts
    • COI: 1:CAS:528:DC%2BD2sXjtFert7w%3D, PID: 17003371
    • Pandrea I et al. Paucity of CD4+ CCR5+ T cells is a typical feature of natural SIV hosts. Blood. 2007;109:1069–76.
    • (2007) Blood , vol.109 , pp. 1069-1076
    • Pandrea, I.1
  • 36
    • 79960131812 scopus 로고    scopus 로고
    • Low levels of SIV infection in sooty mangabey central memory CD(4)(+) T cells are associated with limited CCR5 expression
    • COI: 1:CAS:528:DC%2BC3MXotV2isb0%3D, PID: 21706028
    • Paiardini M et al. Low levels of SIV infection in sooty mangabey central memory CD(4)(+) T cells are associated with limited CCR5 expression. Nat Med. 2011;17:830–6.
    • (2011) Nat Med , vol.17 , pp. 830-836
    • Paiardini, M.1
  • 37
    • 84897382112 scopus 로고    scopus 로고
    • Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques
    • PID: 24604066
    • Chahroudi A et al. Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques. PLoS Pathog. 2014;10:e1003958.
    • (2014) PLoS Pathog , vol.10 , pp. e1003958
    • Chahroudi, A.1
  • 38
    • 43949085373 scopus 로고    scopus 로고
    • Paucity of CD4+ CCR5+ T cells may prevent transmission of simian immunodeficiency virus in natural nonhuman primate hosts by breast-feeding
    • COI: 1:CAS:528:DC%2BD1cXmt1SlsL0%3D, PID: 18385229
    • Pandrea I et al. Paucity of CD4+ CCR5+ T cells may prevent transmission of simian immunodeficiency virus in natural nonhuman primate hosts by breast-feeding. J Virol. 2008;82:5501–9.
    • (2008) J Virol , vol.82 , pp. 5501-5509
    • Pandrea, I.1
  • 39
    • 84861403625 scopus 로고    scopus 로고
    • Mucosal simian immunodeficiency virus transmission in African green monkeys: susceptibility to infection is proportional to target cell availability at mucosal sites
    • COI: 1:CAS:528:DC%2BC38XlsVCgsr0%3D, PID: 22318138
    • Pandrea I et al. Mucosal simian immunodeficiency virus transmission in African green monkeys: susceptibility to infection is proportional to target cell availability at mucosal sites. J Virol. 2012;86:4158–68.
    • (2012) J Virol , vol.86 , pp. 4158-4168
    • Pandrea, I.1
  • 40
    • 9144261631 scopus 로고    scopus 로고
    • T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis
    • COI: 1:CAS:528:DC%2BD2cXmsFSkug%3D%3D, PID: 14722271
    • Brenchley JM et al. T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis. J Virol. 2004;78:1160–8.
    • (2004) J Virol , vol.78 , pp. 1160-1168
    • Brenchley, J.M.1
  • 41
    • 34548413609 scopus 로고    scopus 로고
    • Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection
    • COI: 1:CAS:528:DC%2BD2sXhtVWnurnP, PID: 17724130
    • Okoye A et al. Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection. J Exp Med. 2007;204:2171–85.
    • (2007) J Exp Med , vol.204 , pp. 2171-2185
    • Okoye, A.1
  • 42
    • 84869814713 scopus 로고    scopus 로고
    • Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections
    • COI: 1:CAS:528:DC%2BC38XhslKmu7nN, PID: 22990012
    • Brenchley JM et al. Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections. Blood. 2012;120:4172–81.
    • (2012) Blood , vol.120 , pp. 4172-4181
    • Brenchley, J.M.1
  • 43
    • 84860255621 scopus 로고    scopus 로고
    • Immune responses driven by protective human leukocyte antigen alleles from long-term nonprogressors are associated with low HIV reservoir in central memory CD4 T cells
    • Descours B et al. Immune responses driven by protective human leukocyte antigen alleles from long-term nonprogressors are associated with low HIV reservoir in central memory CD4 T cells. Clin Infect Dis. 2012;54:1495–503.
    • (2012) Clin Infect Dis , vol.54 , pp. 1495-1503
    • Descours, B.1
  • 44
    • 84875985311 scopus 로고    scopus 로고
    • Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study
    • COI: 1:CAS:528:DC%2BC3sXmtVeltbo%3D, PID: 23516360
    • Saez-Cirion A et al. Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. PLoS Pathog. 2013;9:e1003211.
    • (2013) PLoS Pathog , vol.9 , pp. e1003211
    • Saez-Cirion, A.1
  • 45
    • 84911432282 scopus 로고    scopus 로고
    • Klatt NR, et al. Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals. PLoS Pathog. 2014;10:e1004345. This study identified a fascinating subset of HIV-1-infected individuals, termed “viremic non-progressors”, that remain clinically healthy in the face of high viral loads. Interestingly, they also found low levels of HIV DNA in CD4+ T
    • SCMcells from these patients, similar to what has been observed in sooty mangabeys.
  • 46
    • 84923794490 scopus 로고    scopus 로고
    • Wnt/catenin signaling in adult stem cell physiology and disease
    • COI: 1:CAS:528:DC%2BC2cXot1ynu7s%3D, PID: 24825509
    • Ring A, Kim YM, Kahn M. Wnt/catenin signaling in adult stem cell physiology and disease. Stem Cell Rev. 2014;10:512–25.
    • (2014) Stem Cell Rev , vol.10 , pp. 512-525
    • Ring, A.1    Kim, Y.M.2    Kahn, M.3
  • 47
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling and disease
    • COI: 1:CAS:528:DC%2BC38XosVaktrg%3D, PID: 22682243
    • Clevers H, Nusse R. Wnt/beta-catenin signaling and disease. Cell. 2012;149:1192–205.
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 48
    • 84903767326 scopus 로고    scopus 로고
    • Can we safely target the WNT pathway?
    • COI: 1:CAS:528:DC%2BC2cXhtVOisbzP, PID: 24981364
    • Kahn M. Can we safely target the WNT pathway? Nat Rev Drug Discov. 2014;13:513–32.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 513-532
    • Kahn, M.1
  • 49
    • 0032532301 scopus 로고    scopus 로고
    • Critical involvement of Tcf-1 in expansion of thymocytes
    • COI: 1:CAS:528:DyaK1cXmsFyrtL4%3D, PID: 9780167
    • Schilham MW et al. Critical involvement of Tcf-1 in expansion of thymocytes. J Immunol. 1998;161:3984–91.
    • (1998) J Immunol , vol.161 , pp. 3984-3991
    • Schilham, M.W.1
  • 50
    • 31144450253 scopus 로고    scopus 로고
    • Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo
    • COI: 1:CAS:528:DC%2BD28XlsFyhtw%3D%3D, PID: 16424171
    • Willinger T et al. Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. J Immunol. 2006;176:1439–46.
    • (2006) J Immunol , vol.176 , pp. 1439-1446
    • Willinger, T.1
  • 51
    • 41549143518 scopus 로고    scopus 로고
    • Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory
    • COI: 1:CAS:528:DC%2BD1cXkvV2it7Y%3D, PID: 18356084
    • Williams MA, Ravkov EV, Bevan MJ. Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory. Immunity. 2008;28:533–45.
    • (2008) Immunity , vol.28 , pp. 533-545
    • Williams, M.A.1    Ravkov, E.V.2    Bevan, M.J.3
  • 52
    • 84887028999 scopus 로고    scopus 로고
    • Absence of detectable HIV-1 viremia after treatment cessation in an infant
    • COI: 1:CAS:528:DC%2BC3sXhslGhtb7M, PID: 24152233
    • Persaud D et al. Absence of detectable HIV-1 viremia after treatment cessation in an infant. N Engl J Med. 2013;369:1828–35.
    • (2013) N Engl J Med , vol.369 , pp. 1828-1835
    • Persaud, D.1
  • 53
    • 60549090253 scopus 로고    scopus 로고
    • Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation
    • PID: 19213682
    • Hutter G et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009;360:692–8.
    • (2009) N Engl J Med , vol.360 , pp. 692-698
    • Hutter, G.1
  • 54
    • 77953715690 scopus 로고    scopus 로고
    • Targeting Wnt signaling: can we safely eradicate cancer stem cells?
    • COI: 1:CAS:528:DC%2BC3cXntlKru7o%3D, PID: 20530697
    • Takahashi-Yanaga F, Kahn M. Targeting Wnt signaling: can we safely eradicate cancer stem cells? Clin Cancer Res. 2010;16:3153–62.
    • (2010) Clin Cancer Res , vol.16 , pp. 3153-3162
    • Takahashi-Yanaga, F.1    Kahn, M.2
  • 55
    • 79551600015 scopus 로고    scopus 로고
    • Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
    • COI: 1:CAS:528:DC%2BC3MXht1yrt7Y%3D, PID: 21151206
    • Takebe N, Harris PJ, Warren RQ, Ivy SP. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol. 2011;8:97–106.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 97-106
    • Takebe, N.1    Harris, P.J.2    Warren, R.Q.3    Ivy, S.P.4
  • 56
    • 84859496112 scopus 로고    scopus 로고
    • Notch signaling in cancer stem cells
    • COI: 1:CAS:528:DC%2BC38Xht12mt7fI, PID: 22399347
    • Wang J, Sullenger BA, Rich JN. Notch signaling in cancer stem cells. Adv Exp Med Biol. 2012;727:174–85.
    • (2012) Adv Exp Med Biol , vol.727 , pp. 174-185
    • Wang, J.1    Sullenger, B.A.2    Rich, J.N.3
  • 57
    • 84908185262 scopus 로고    scopus 로고
    • Safely targeting cancer stem cells via selective catenin coactivator antagonism
    • COI: 1:CAS:528:DC%2BC2cXhsFymu7rN, PID: 24975284
    • Lenz HJ, Kahn M. Safely targeting cancer stem cells via selective catenin coactivator antagonism. Cancer Sci. 2014;105:1087–92.
    • (2014) Cancer Sci , vol.105 , pp. 1087-1092
    • Lenz, H.J.1    Kahn, M.2
  • 58
    • 79952653986 scopus 로고    scopus 로고
    • HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells
    • COI: 1:CAS:528:DC%2BC3MXjtFOmsr0%3D, PID: 21402361
    • Carter CC et al. HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells. Cell Host Microbe. 2011;9:223–34.
    • (2011) Cell Host Microbe , vol.9 , pp. 223-234
    • Carter, C.C.1
  • 59
    • 79954449119 scopus 로고    scopus 로고
    • Hematopoietic stem/precursor cells as HIV reservoirs
    • PID: 21242893
    • McNamara LA, Collins KL. Hematopoietic stem/precursor cells as HIV reservoirs. Curr Opin HIV AIDS. 2011;6:43–8.
    • (2011) Curr Opin HIV AIDS , vol.6 , pp. 43-48
    • McNamara, L.A.1    Collins, K.L.2
  • 60
    • 84861559237 scopus 로고    scopus 로고
    • Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA
    • COI: 1:CAS:528:DC%2BC38XnvVOqtbw%3D, PID: 22536001
    • Josefsson L et al. Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA. J Infect Dis. 2012;206:28–34.
    • (2012) J Infect Dis , vol.206 , pp. 28-34
    • Josefsson, L.1
  • 61
    • 84863242863 scopus 로고    scopus 로고
    • HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy
    • COI: 1:CAS:528:DC%2BC38XjtFKntLw%3D, PID: 22275402
    • Durand CM et al. HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy. J Infect Dis. 2012;205:1014–8.
    • (2012) J Infect Dis , vol.205 , pp. 1014-1018
    • Durand, C.M.1
  • 62
    • 33846809447 scopus 로고    scopus 로고
    • Primitive hematopoietic cells resist HIV-1 infection via p21
    • COI: 1:CAS:528:DC%2BD2sXhs1Oqt74%3D, PID: 17273559
    • Zhang J, Scadden DT, Crumpacker CS. Primitive hematopoietic cells resist HIV-1 infection via p21. J Clin Invest. 2007;117:473–81.
    • (2007) J Clin Invest , vol.117 , pp. 473-481
    • Zhang, J.1    Scadden, D.T.2    Crumpacker, C.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.