Downregulation of miR-518a-3p activates the NIK-dependent NF-κB pathway in colorectal cancer

International Journal of Molecular Medicine

Volumn 35, Issue 5, 2015, Pages 1266-1272

  Qu, L L ^a   He, L ^a   Zhao, X ^a   Xu, W ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

Colorectal cancer; MiR 518a 3p; Nuclear factor B activation; Nuclear factor B inducing kinase

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MICRORNA; MICRORNA 518A 3P; NF KAPPA B INDUCING KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; MIRN518 MICRORNA, HUMAN; NF-KAPPA B KINASE; PROTEIN SERINE THREONINE KINASE;

3' UNTRANSLATED REGION; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER GROWTH; CANCER TISSUE; CELL GROWTH; COLORECTAL CANCER; CONTROLLED STUDY; DISTANT METASTASIS; DOWN REGULATION; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HCT116 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUCIFERASE ASSAY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR INVASION; TUMOR VOLUME; WESTERN BLOTTING; BINDING SITE; CHEMISTRY; COLORECTAL TUMOR; GENETICS; METABOLISM; METASTASIS; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; BINDING SITES; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; NEOPLASM METASTASIS; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84925433152     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2015.2145     Document Type: Article

References (30)

1. Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin 60:277-300, 2010.
2. Hironaka N, Mochida K, Mori N, Maeda M, Yamamoto N and Yamaoka S: Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells. Neoplasia 6:266-278, 2004.
3. Prasad S, Ravindran J and Aggarwal BB: NF-kappaB and cancer: How intimate is this relationship. Mol Cell Biochem 336:25-37, 2010.
4. Claudius AK, Kankipati CS, Kilari RS, Hassan S, Guest K, Russell ST, Perry CJ, Stark LA and Nicholl ID: Identification of aspirin analogues that repress NF-kB signalling and demonstrate anti-proliferative activity towards colorectal cancer in vitro and in vivo. Oncol Rep 32:1670-1680, 2014
5. Yang H, Qi H, Ren J, Cui J, Li Z, Waldum HL and Cui G: Involvement of NF-kB/IL-6 pathway in the processing of colorectal carcinogenesis in colitis mice. Int J Inflam 2014:130981, 2014
6. Thu YM, Su Y, Yang J, Splittgerber R, Na S, Boyd A, Mosse C, Simons C and Richmond A: NF-kB inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the β-catenin pathway. Oncogene 31:2580-2592, 2012.
7. Thu YM and Richmond A: NF-kB inducing kinase: A key regulator in the immune system and in cancer. Cytokine Growth Factor Rev 21:213-226, 2010.
8. Annunziata CM, Davis RE, Demchenko Y, Bellamy W, Gabrea A, Zhan F, Lenz G, Hanamura I, Wright G, Xiao W, et al: Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 12:115-130, 2007
9. Zhao JL and Starczynowski DT: Role of microRNA-146a in normal and malignant hematopoietic stem cell function. Front Genet 5:219, 2014
10. Bandres E, Bitarte N, Arias F, Agorreta J, Fortes P, Agirre X, Zarate R, Diaz-Gonzalez JA, Ramirez N, Sola JJ, et al: microRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells. Clin Cancer Res 15:2281-2290, 2009
11. Chen X, Guo X, Zhang H, Xiang Y, Chen J, Yin Y, Cai X, Wang K, Wang G, Ba Y, et al: Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene 28:1385-1392, 2009
12. Zhang J, Wu H, Li P, Zhao Y, Liu M and Tang H: NF-KB-modulated miR-130a targets TNF-α in cervical cancer cells. J Transl Med 12:155, 2014
13. Liu Z, Gersbach E, Zhang X, Xu X, Dong R, Lee P, Liu J, Kong B, Shao C and Wei JJ: miR-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma. Mol Cancer Res 11:1314-1325, 2013.
14. Abdelmohsen K, Srikantan S, Kuwano Y and Gorospe M: miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels. Proc Natl Acad Sci USA 105:20297-20302, 2008.
15. ∗ and miR-630 induces apoptosis in pancreatic cancer cells by targeting IGF-1R. PLoS One 8:e61015, 2013.
16. Guo J, Li M, Meng X, Sui J, Dou L, Tang W, Huang X, Man Y, Wang S and Li J: MiR-291b-3p induces apoptosis in liver cell line NCTC1469 by reducing the level of RNA-binding protein HuR. Cell Physiol Biochem 33:810-822, 2014
17. Odqvist L, Sánchez-Beato M, Montes-Moreno S, et al: NIK controls classical and alternative NF-kB activation and is necessary for the survival of human T-cell lymphoma cells. Clin Cancer Res 19:2319-2330, 2013.
18. Li M, Wang X, Liu M, Qi X and Li J: NF-kB signaling inhibition and anticancer activities of LLDT-246 on human colorectal cancer HCT-116 cells in vitro. Biomed Pharmacother 68:527-535, 2014
19. Hajder J, Marisavljevic D, Stanisavljevic N, Mihaljevic B, Kovcin V, Markovic O and Zivkovic R: BCL10 aberations and NF-kappa B activation involving p65 are absent or rare in primary gastric MALT lymphoma. Vojnosanit Pregl 71:1040-1044, 2014
20. Celegato M, Borghese C, Casagrande N, Carbone A, Colombatti A and Aldinucci D: Bortezomib down-modulates the survival factor interferon regulatory factor 4 in Hodgkin lymphoma cell lines and decreases the protective activity of Hodgkin lymphomaassociated fibroblasts. Leuk Lymphoma 55:149-159, 2014
21. Hayden MS and Ghosh S: Shared principles in NF-kappaB signaling. Cell 132:344-362, 2008.
22. Kupcinskas J, Bruzaite I, Juzenas S, Gyvyte U, Jonaitis L, Kiudelis G, Skieceviciene J, Leja M, Pauzas H, Tamelis A, et al: Lack of association between miR-27a, miR-146a, miR-196a-2, miR-492 and miR-608 gene polymorphisms and colorectal cancer. Sci Rep 4:5993, 2014
23. Rodríguez-Montes JA and Menéndez Sánchez P: Role of micro-RNA in colorectal cancer screening. Cir Esp 92:654-658, 2014
24. Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, et al: MicroRNA-21 induces resistance to 5-fuorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci USA 107:21098-21103, 2010.
25. Wang CJ, Stratmann J, Zhou ZG and Sun XF: Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells. BMC Cancer 10:616, 2010.
26. Boni V, Bitarte N, Cristobal I, Zarate R, Rodriguez J, Maiello E, Garcia-Foncillas J and Bandres E: miR-192/miR-215 infuence 5-fluorouracil resistance through cell cycle-mediated mechanisms complementary to its post-transcriptional thymidilate synthase regulation. Mol Cancer Ther 9:2265-2275, 2010.
27. Wang Z, Sun X, Wang Y, Liu X, Xuan Y and Hu S: Association between miR-27a genetic variants and susceptibility to colorectal cancer. Diagn Pathol 9:146, 2014
28. Wang S, Yang MH, Wang XY, Lin J and Ding YQ: Increased expression of miRNA-182 in colorectal carcinoma: An independent and tissue-specific prognostic factor. Int J Clin Exp Pathol 7:3498-3503, 2014
29. Huh JH, Kim TH, Kim K, Song JA, Jung YJ, Jeong JY, Lee MJ, Kim YK, Lee DH and An HJ: Dysregulation of miR-106a and miR-591 confers paclitaxel resistance to ovarian cancer. Br J Cancer 109:452-461, 2013.
30. Plummer SM, Holloway KA, Manson MM, Munks RJ, Kaptein A, Farrow S and Howells L: Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. Oncogene 18:6013-6020, 1999