Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 12, 2015, Pages 3680-3685

  Bagnoli, Fabio ^a   Fontana, Maria Rita ^a   Soldaini, Elisabetta ^a   Mishra, Ravi P N ^a   Fiaschi, Luigi ^a   Cartocci, Elena ^a   Nardi Dei, Vincenzo ^a   Ruggiero, Paolo ^a   Nosari, Sarah ^a   De Falco, Maria Grazia ^a   Lofano, Giuseppe ^a   Marchi, Sara ^a   Galletti, Bruno ^a   Mariotti, Paolo ^a   Bacconi, Marta ^a   Torre, Antonina ^a   Maccari, Silvia ^a   Scarselli, Maria ^a   Rinaudo, C Daniela ^a   Inoshima, Naoko ^b   Savino, Silvana ^a   Mori, Elena ^a   Rossi Paccani, Silvia ^a   Baudner, Barbara ^a   Pallaoro, Michele ^a   Swennen, Erwin ^a   Petracca, Roberto ^a   Brettoni, Cecilia ^a   Liberatori, Sabrina ^a   Norais, Nathalie ^a   Monaci, Elisabetta ^a   Wardenburg, Juliane Bubeck ^b   Schneewind, Olaf ^b   O'Hagan, Derek T ^a   Valiante, Nicholas M ^a   Bensi, Giuliano ^a   Bertholet, Sylvie ^a   De Gregorio, Ennio ^a   Rappuoli, Rino ^a   Grandi, Guido ^a   more..

^a NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Adjuvant; Hla; Staphylococcus aureus; TLR7; Vaccine

Indexed keywords

ALPHA HEMOLYSIN; ALUMINUM HYDROXIDE; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CONSERVED STAPHYLOCOCCAL ANTIGEN 1A; ESS EXTRACELLULAR A; ESS EXTRACELLULAR B; FERRIC HYDROXAMATE UPTAKE D2 PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2B; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; STAPHYLOCOCCUS PROTEIN A; STAPHYLOCOCCUS VACCINE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; VIRULENCE FACTOR; ANTIGEN; ANTIINFECTIVE AGENT; BACTERIUM ANTIBODY; TLR7 PROTEIN, HUMAN;

ABSCESS; ADJUVANT THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; APOPTOSIS; ARTICLE; B LYMPHOCYTE; BACTERIAL PERITONITIS; BACTERIAL STRAIN; BACTERIUM ISOLATE; BIOINFORMATICS; CD4+ T LYMPHOCYTE; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG FORMULATION; HOST CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOREACTIVITY; IRON TRANSPORT; KIDNEY HOMOGENATE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; SEQUENCE ANALYSIS; SKIN NECROSIS; STAPHYLOCOCCAL PNEUMONIA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STOP CODON; SUPERNATANT; SURVIVAL RATE; SURVIVAL TIME; T LYMPHOCYTE; WESTERN BLOTTING; ADAPTIVE IMMUNITY; ANIMAL; CHEMISTRY; HUMAN; IMMUNOLOGY; PATHOLOGY; STAPHYLOCOCCAL INFECTIONS; TH1 CELL;

STAPHYLOCOCCUS AUREUS;

ABSCESS; ADAPTIVE IMMUNITY; ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBODIES, BACTERIAL; ANTIGENS; HUMANS; MICE; MODELS, ANIMAL; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCAL VACCINES; STAPHYLOCOCCUS AUREUS; TH1 CELLS; TOLL-LIKE RECEPTOR 7;

EID: 84925422900     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1424924112     Document Type: Article

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