Maternal childhood adversity and child temperament: An association moderated by child 5-HTTLPR genotype

Genes, Brain and Behavior

Volumn 14, Issue 3, 2015, Pages 229-237

  Bouvette Turcot, Andrée Anne ^a,b   Fleming, A S ^b   Wazana, A ^a,c   Sokolowski, M B ^d,e   Gaudreau, H ^a   Gonzalez, A ^f   Deslauriers, J ^b   Kennedy, J L ^d   Steiner, M ^f,g   Meaney, M J ^a,h  

^a DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e ST JOSEPH S HOSPITAL   (Canada)

^f MCMASTER UNIVERSITY   (Canada)

^g MCMASTER UNIVERSITY   (Canada)

^h AGENCY FOR SCIENCE   (Singapore)

Author keywords

5 HTTLPR genotype; Differential susceptibility; Maternal adversity; Negative emotionality; Transgenerational transmission

Indexed keywords

SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

ADULT; ARTICLE; CHILD BEHAVIOR; CHILDHOOD TRAUMA QUESTIONNAIRE; CLINICAL ASSESSMENT TOOL; EARLY CHILDHOOD BEHAVIOUR QUESTIONNAIRE; EMOTIONALITY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MATERNAL CHILDHOOD ADVERSITY; MEDICAL HISTORY; MENTAL DISEASE; MOTHER CHILD RELATION; PARENTAL BONDING INDEX; PERSONAL EXPERIENCE; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; PSYCHOSOCIAL DISORDER; PUERPERAL DEPRESSION; QUESTIONNAIRE; TEMPERAMENT; CHILD ABUSE; COHORT ANALYSIS; DEPRESSION; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; LONGITUDINAL STUDY; NEWBORN; PREGNANCY; PRESCHOOL CHILD; PSYCHOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CHILD ABUSE; CHILD, PRESCHOOL; COHORT STUDIES; DEPRESSION; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT; INFANT, NEWBORN; LONGITUDINAL STUDIES; MOTHER-CHILD RELATIONS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TEMPERAMENT;

EID: 84925411667     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/gbb.12205     Document Type: Article

References (50)

1. Anthony, J.L., Lonigan, C.J., Hooe, E.S. & Phillips, B.M. (2002) An affect-based, hierarchical model of temperament and its relations with internalizing symptomatology. J Clin Child Adolesc 31, 480-490.
2. Belsky, J. & Pluess, M. (2009a) Beyond diathesis stress: differential susceptibility to environmental influences. Psychol Bull 135, 885-908.
3. Belsky, J. & Pluess, M. (2009b) The nature (and nurture?) of plasticity in early human development. Perspect Psychol Sci 4, 345-351.
4. Belsky, J., Jaffee, S.R., Sligo, J., Woodward, L. & Silva, P.A. (2005) Intergenerational transmission of warm-sensitive-stimulating parenting: a prospective study of mothers and fathers of 3-year-olds. Child Dev 76, 384-396.
5. Bernstein, D.P., Fink, L., Handelsman, L., Foote, J., Lovejoy, M., Wenzel, K., Sapareto, E. & Ruggiero, J. (1994) Initial reliability and validity of a new retrospective measure of child abuse and neglect. Am J Psychiatry 151, 1132-1136.
6. Bruder-Costello, B., Warner, V., Talati, A., Nomura, Y., Bruder, G. & Weissman, M. (2007) Temperament among offspring at high and low risk for depression. Psychiatry Res 153, 145-151.
7. Caspi, A., Moffitt, T.E., Newman, D.L. & Silva, P.A. (1996) Behavioral observations at age 3 years predict adult psychiatric disorders - longitudinal evidence from a birth cohort. Arch Gen Psychiatry 53, 1033-1039.
8. Caspi, A., Sugden, K., Moffitt, T.E., Taylor, A., Craig, I.W., Harrington, H., McClay, J., Mill, J., Martin, J.L., Braithwaite, A. & Poulton, R. (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 386-389.
9. Chen, L., Pan, H., Tuan, T.A., Teh, A.L., MacIsaac, J.L., Mah, S.M., McEwen, L.M., Li, Y., Chen, H., Broekman, B.F.P., Buschdorf, J.P., Chong, Y.S., Kwek, K., Saw, S.M., Gluckman, P.D., Fortier, M.V., Rifkin-Graboi, A., Kobor, M.S., Qiu, A., Meaney, M.J. & Holbrook, J.D. (2015) Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes. Dev Psychopathol 27, 137-150.
10. Collishaw, S., Dunn, J., O'Connor, T.G. & Golding, J. (2007) Maternal childhood abuse and offspring adjustment over time. Dev Psychopathol 19, 367-383.
11. Cook, E.H., Courchesne, R., Lord, C., Cox, N.J., Shuya, Y., Lincoln, A., Haas, R., Courchesne, E. & Leventhal, B.L. (1997) Evidence of linkage between the serotonin transporter and autistic disorder. Mol Psychiatry 2, 247-250.
12. Degnan, K.A., Almas, A.N. & Fox, N.A. (2010) Temperament and the environment in the etiology of childhood anxiety. J Child Psychol Psychiatry 51, 497-517.
13. Fox, N.A., Nichols, K.E., Henderson, H.A., Rubin, K., Schmidt, L., Hamer, D., Ernst, M. & Pine, D.S. (2005) Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood. Psychol Sci 16, 921-926.
14. Francis, D., Diorio, J., Liu, D. & Meaney, M.J. (1999) Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science 286, 1155-1158.
15. Gonzalez, A., Lovic, V., Ward, G.R., Wainwright, P.E. & Fleming, A.S. (2001) Intergenerational effects of complete maternal deprivation and replacement stimulation on maternal behavior and emotionality in female rats. Dev Psychobiol 38, 11-32.
16. Gonzalez, A., Jenkins, J.M., Steiner, M. & Fleming, A.S. (2012) Maternal early life experiences and parenting: the mediating role of cortisol and executive function. J Am Acad Child Psychiatry 51, 673-682.
17. Goodman, R. (1997) The Strengths and Difficulties Questionnaire: a research note. J Child Psychol Psychiatry 38, 581-586.
18. Goodman, S.H., Rouse, M.H., Connell, A.M., Broth, M.R., Hall, C.M. & Heyward, D. (2011) Maternal depression and child psychopathology: a meta-analytic review. Clin Child Fam Psychol 14, 1-27.
19. Hane, A.A. & Fox, N.A. (2006) Ordinary variations in maternal caregiving influence human infants' stress reactivity. Psychol Sci 17, 550-556.
20. Heim, C. & Nemeroff, C.B. (2001) The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry 49, 1023-1039.
21. Hill, J., Pickles, A., Burnside, E., Byatt, M., Rollinson, L., Davis, R. & Harvey, K. (2001) Child sexual abuse, poor parental care and adult depression: evidence for different mechanisms. Brit J Psychiatry 179, 104-109.
22. Holmbeck, G.N. (2002) Post-hoc probing of significant moderational and mediational effects in studies of pediatric populations. J Pediatr Psychol 27, 87-96.
23. Homberg, J.R. & Lesch, K.-P. (2011) Looking on the bright side of serotonin transporter gene variation. Biol Psychiatry 69, 513-519.
24. Hu, X.Z., Lipsky, R.H., Zhu, G., Akhtar, L.A., Taubman, J., Greenberg, B.D., Xu, K., Arnold, P.D., Richter, M.A., Kennedy, J.L., Murphy, D.L. & Goldman, D. (2006) Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 78, 815-826.
25. Kendler, K.S., Bulik, C.M., Silberg, J., Hettema, J.M., Myers, J. & Prescott, C.A. (2000) Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis. Arch Gen Psychiatry 57, 953-959.
26. Kochanska, G., Philibert, R.A. & Barry, R.A. (2009) Interplay of genes and early mother-child relationship in the development of self-regulation from toddler to preschool age. J Child Psychol Psychiatry 50, 1331-1338.
27. Maestripieri, D. & Mateo, J.M. (2009) Maternal Effects in Mammals. U Chicago Press.
28. Meaney, M.J. (2010) Epigenetics and the biological definition of gene x environment interactions. Child Dev 81, 41-79.
29. Mileva-Seitz, V., Kennedy, J., Atkinson, L., Steiner, M., Levitan, R., Matthews, S.G., Meaney, M.J., Sokolowski, M.B. & Fleming, A.S. (2011) Serotonin transporter allelic variation in mothers predicts maternal sensitivity, behavior and attitudes toward 6-month-old infants. Genes Brain Behav 10, 325-333.
30. Miller, L., Kramer, R., Warner, V., Wickramaratne, P. & Weissman, M. (1997) Intergenerational transmission of parental bonding among women. J Am Acad Child Psychiatry 36, 1134-1139.
31. Molnar, B.E., Buka, S.L. & Kessler, R.C. (2001) Child sexual abuse and subsequent psychopathology: results from the National Comorbidity Survey. Am J Public Health 91, 753-760.
32. Nanni, V., Uher, R. & Danese, A. (2012) Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. Am J Psychiatry 169, 141-151.
33. Parker, G., Tupling, H. & Brown, L.B. (1979) A parental bonding instrument. Brit J Med Psychol 52, 1-10.
34. Pluess, M., Velders, F.P., Belsky, J., van IJzendoorn, M.H., Bakermans-Kranenburg, M.J., Jaddoe, V.W., Hofman, A., Arp, P.P., Verhulst, F.C. & Tiemeier, H. (2011) Serotonin transporter polymorphism moderates effects of prenatal maternal anxiety on infant negative emotionality. Biol Psychiatry 69, 520-525.
35. Praschak-Rieder, N., Wilson, A.A., Hussey, D., Carella, A., Wei, C., Ginovart, N., Schwarz, M.J., Zach, J., Houle, S. & Meyer, J.H. (2005) Effects of tryptophan depletion on the serotonin transporter in healthy humans. Biol Psychiatry 58, 825-830.
36. Putnam, S.P., Gartstein, M.A. & Rothbart, M.K. (2006) Measurement of fine-grained aspects of toddler temperament: the early childhood behavior questionnaire. Infant Behav Dev 29, 386-401.
37. Radloff, L.S. (1997) The CES-D Scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1, 385-401.
38. Reimold, M., Smolka, M.N., Schumann, G., Zimmer, A., Wrase, J., Mann, K., Hu, X.Z., Goldman, D., Reischl, G., Solbach, C., Machulla, H.J., Bares, R. & Heinz, A. (2007) Midbrain serotonin transporter binding potential measured with [11C]DASB is affected by serotonin transporter genotype. J Neural Transm 114, 635-639.
39. Roberts, R., O'Connor, T., Dunn, J., Golding, J. & the ALSPAC Study team (2004) The effects of child sexual abuse in later family life; mental health, parenting and adjustment of offspring. Child Abuse Neglect 28, 525-545.
40. Rothbart, M.K. & Posner, M.I. (2006) Temperament, attention, and developmental psychopathology. In Cicchetti, D. & Cohen, D.J. (eds), Developmental Psychopathology. Developmental Neuroscience, 2nd edn. Vol. 2. John Wiley & Sons, Hoboken, NJ, pp. 465-501.
41. Rutter, M., Moffitt, T.E. & Caspi, A. (2006) Gene-environment interplay and psychopathology: multiple varieties but real effects. J Child Psychol Psychiatry 47, 226-261.
42. Shanahan, L., Copeland, W., Costello, E.J. & Angold, A. (2008) Specificity of putative psychosocial risk factors for psychiatric disorders in children and adolescents. J Child Psychol Psychiatry 49, 34-42.
43. Stein, M.B., Walker, J.R., Anderson, G., Hazen, A.L., Ross, C.A., Eldridge, G. & Forde, D.R. (1996) Childhood physical and sexual abuse in patients with anxiety disorders and in a community sample. Am J Psychiatry 153, 275-277.
44. Taylor, S.E. (2010) Mechanisms linking early life stress to adult health outcomes. Proc Natl Acad Sci USA 107, 8507-8512.
45. Tronick, E. & Reck, C. (2009) Infants of depressed mothers. Harvard Rev Psychiatry 17, 147-156.
46. Uher, R. & McGuffin, P. (2008) The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Mol Psychiatry 13, 131-146.
47. Weissman, M.M., Wickramaratne, P., Nomura, Y., Warner, V., Pilowsky, D. & Verdeli, H. (2006) Offspring of depressed parents: 20 years later. Am J Psychiatry 163, 1001-1008.
48. Wickramaratne, P., Gameroff, M.J., Pilowsky, D.J., Hughes, C.W., Garber, J., Malloy, E., King, C., Cerda, G., Sood, A.B., Alpert, J.E., Trivedi, M.H., Fava, M., Rush, A.J., Wisniewski, S. & Weissman, M.M. (2011) Children of depressed mothers 1 year after remission of maternal depression: findings from the STAR* D-Child study. Am J Psychiatry 168, 593-602.
49. Widom, C.S., DuMont, K. & Czaja, S.J. (2007) A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Arch Gen Psychiatry 64, 49-56.
50. Wilhelm, K., Niven, H., Parker, G. & Hadzi-Pavlovic, D. (2005) The stability of the Parental Bonding Instrument over a 20-year period. Psychol Med 35, 387-393.