Inhibition of hepatitis B virus gene expression and replication by hepatocyte nuclear factor 6

Journal of Virology

Volumn 89, Issue 8, 2015, Pages 4345-4355

  Hao, Ruidong ^a   He, Jing ^a   Liu, Xing ^a   Gao, Guozhen ^b   Liu, Dan ^a   Cui, Lei ^a   Yu, Guojun ^a   Yu, Wenhui ^a   Chen, Yu ^a   Guo, Deyin ^a  

^a WUHAN UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 6; LA ANTIGEN; MESSENGER RNA; PREGENOMIC RNA; RNA; UNCLASSIFIED DRUG; VIRUS RNA; LUCIFERASE; PRIMER DNA; SMALL INTERFERING RNA;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA REPLICATION; EMBRYO; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENE SILENCING; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RNA DEGRADATION; VIRUS GENE; VIRUS GENOME; ANIMAL; FEMALE; GENE EXPRESSION REGULATION; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; IMMUNOHISTOCHEMISTRY; METABOLISM; NORTHERN BLOTTING; PROCEDURES; REAL TIME POLYMERASE CHAIN REACTION; SEXUAL DEVELOPMENT; TUMOR CELL LINE; WESTERN BLOTTING;

DNA VIRUSES; HEPATITIS B VIRUS;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE, TUMOR; DNA PRIMERS; DNA REPLICATION; FEMALE; GENE EXPRESSION REGULATION, VIRAL; GENETIC VECTORS; HEK293 CELLS; HEPATITIS B VIRUS; HEPATOCYTE NUCLEAR FACTOR 6; HUMANS; IMMUNOHISTOCHEMISTRY; LUCIFERASES; MALE; MICE; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SEX CHARACTERISTICS; TRANSFECTION;

EID: 84925400633     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.03094-14     Document Type: Article

References (35)

1. Seeger C, Mason WS. 2000. Hepatitis B virus biology. Microbiol Mol Biol Rev 64:51-68. http://dx.doi.org/10.1128/MMBR.64.1.51-68.2000.
2. Arzumanyan A, Reis HM, Feitelson MA. 2013. Pathogenic mechanisms in HBV-and HCV-associated hepatocellular carcinoma. Nature reviews. Cancer 13:123-135. http://dx.doi.org/10.1038/nrc3449.
3. Beck J, Nassal M. 2007. Hepatitis B virus replication. World J Gastroenterol 13:48-64. http://dx.doi.org/10.3748/wjg.v13.i1.48.
4. Schädler S, Hildt E. 2009. HBV life cycle: entry and morphogenesis. Viruses 1:185-209. http://dx.doi.org/10.3390/v1020185.
5. Grimm D, Thimme R, Blum HE. 2011. HBV life cycle and novel drug targets. Hepatol Int 5:644-653. http://dx.doi.org/10.1007/s12072-011-9261-3.
6. Schrem H, Klempnauer J, Borlak J. 2002. Liver-enriched transcription factors in liver function and development. I. The hepatocyte nuclear factor network and liver-specific gene expression. Pharmacol Rev 54:129-158.
7. Schrem H, Klempnauer J, Borlak J. 2004. Liver-enriched transcription factors in liver function and development. II. The C/EBPs and D sitebinding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation. Pharmacol Rev 56:291-330. http://dx.doi.org/10.1124/pr.56.2.5.
8. Wang WX, Li M, Wu X, Wang Y, Li ZP. 1998. HNF1 is critical for the liver-specific function of HBV enhancer II. Res Virol 149:99-108. http://dx.doi.org/10.1016/S0923-2516(98)80085-X.
9. Tang H, McLachlan A. 2001. Transcriptional regulation of hepatitis B virus by nuclear hormone receptors is a critical determinant of viral tropism. Proc Natl Acad Sci U S A 98:1841-1846. http://dx.doi.org/10.1073/pnas.98.4.1841.
10. Tang H, McLachlan A. 2002. Mechanisms of inhibition of nuclear hormone receptor-dependent hepatitis B virus replication by hepatocyte nuclear factor 3. J Virol 76:8572-8581. http://dx.doi.org/10.1128/JVI.76.17.8572-8581.2002.
11. Buckwold VE, Xu Z, Chen M, Yen TS, Ou JH. 1996. Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol 70:5845-5851.
12. Lemaigre FP, Durviaux SM, Truong O, Lannoy VJ, Hsuan JJ, Rousseau GG. 1996. Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain. Proc Natl Acad Sci U S A 93:9460-9464. http://dx.doi.org/10.1073/pnas.93.18.9460.
13. Wang K, Holterman AX. 2012. Pathophysiologic role of hepatocyte nuclear factor 6. Cell Signal 24:9-16. http://dx.doi.org/10.1016/j.cellsig.2011.08.009.
14. Holterman AX, Tan Y, Kim W, Yoo KW, Costa RH. 2002. Diminished hepatic expression of the HNF-6 transcription factor during bile duct obstruction. Hepatology 35:1392-1399. http://dx.doi.org/10.1053/jhep.2002.33680.
15. Wang M, Tan Y, Costa RH, Holterman AX. 2004. In vivo regulation of murine CYP7A1 by HNF-6: a novel mechanism for diminished CYP7A1 expression in biliary obstruction. Hepatology 40:600-608. http://dx.doi.org/10.1002/hep.20349.
16. Wang M, Chen M, Zheng G, Dillard B, Tallarico M, Ortiz Z, Holterman AX. 2008. Transcriptional activation by growth hormone of HNF-6-regulated hepatic genes, a potential mechanism for improved liver repair during biliary injury in mice. Am J Physiol Gastrointest Liver Physiol 295:G357-G366. http://dx.doi.org/10.1152/ajpgi.00581.2007.
17. Lahuna O, Fernandez L, Karlsson H, Maiter D, Lemaigre FP, Rousseau GG, Gustafsson J, Mode A. 1997. Expression of hepatocyte nuclear factor 6 in rat liver is sex-dependent and regulated by growth hormone. Proc Natl Acad Sci U S A 94:12309-12313. http://dx.doi.org/10.1073/pnas.94.23.12309.
18. Schormann W, Kraft A, Ponsel D, Bruss V. 2006. Hepatitis B virus particle formation in the absence of pregenomic RNA and reverse transcriptase. J Virol 80:4187-4190. http://dx.doi.org/10.1128/JVI.80.8.4187-4190.2006.
19. Guo H, Jiang D, Ma D, Chang J, Dougherty AM, Cuconati A, Block TM, Guo JT. 2009. Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells. J Virol 83:847-858. http://dx.doi.org/10.1128/JVI.02008-08.
20. Tian Y, Chen WL, Ou JH. 2011. Effects of interferon-alpha/beta on HBV replication determined by viral load. PLoS Pathog 7:e1002159. http://dx.doi.org/10.1371/journal.ppat.1002159.
21. Werle-Lapostolle B, Bowden S, Locarnini S, Wursthorn K, Petersen J, Lau G, Trepo C, Marcellin P, Goodman Z, Delaney WE 4th, Xiong S, Brosgart CL, Chen SS, Gibbs CS, Zoulim F. 2004. Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology 126:1750-1758. http://dx.doi.org/10.1053/j.gastro.2004.03.018.
22. Gilman M. 2002. Preparation of cytoplasmic RNA from tissue culture cells. Curr Protoc Mol Biol Chapter 4:Unit 4.1. http://dx.doi.org/10.1002/0471142727.mb0401s58.
23. Banks KE, Anderson AL, Tang H, Hughes DE, Costa RH, McLachlan A. 2002. Hepatocyte nuclear factor 3beta inhibits hepatitis B virus replication in vivo. J Virol 76:12974-12980. http://dx.doi.org/10.1128/JVI.76.24.12974-12980.2002.
24. Tsui LV, Guidotti LG, Ishikawa T, Chisari FV. 1995. Posttranscriptional clearance of hepatitis B virus RNA by cytotoxic T lymphocyte-activated hepatocytes. Proc Natl Acad Sci U S A 92:12398-12402. http://dx.doi.org/10.1073/pnas.92.26.12398.
25. Heise T, Guidotti LG, Chisari FV. 1999. La autoantigen specifically recognizes a predicted stem-loop in hepatitis B virus RNA. J Virol 73: 5767-5776.
26. Ehlers I, Horke S, Reumann K, Rang A, Grosse F, Will H, Heise T. 2004. Functional characterization of the interaction between human La and hepatitis B virus RNA. J Biol Chem 279:43437-43447. http://dx.doi.org/10.1074/jbc.M402227200.
27. Lannoy VJ, Rodolosse A, Pierreux CE, Rousseau GG, Lemaigre FP. 2000. Transcriptional stimulation by hepatocyte nuclear factor-6. Targetspecific recruitment of either CREB-binding protein (CBP) or p300/CBPassociated factor (p/CAF). J Biol Chem 275:22098-22103. http://dx.doi.org/10.1074/jbc.M000855200.
28. Zheng Y, Li J, Ou JH. 2004. Regulation of hepatitis B virus core promoter by transcription factors HNF1 and HNF4 and the viral X protein. J Virol 78:6908-6914. http://dx.doi.org/10.1128/JVI.78.13.6908-6914.2004.
29. Zhou J, Tan T, Tian Y, Zheng B, Ou JH, Huang EJ, Yen TS. 2011. Kruppel-like factor 15 activates hepatitis B virus gene expression and replication. Hepatology 54:109-121. http://dx.doi.org/10.1002/hep.24362.
30. Mao R, Nie H, Cai D, Zhang J, Liu H, Yan R, Cuconati A, Block TM, Guo JT, Guo H. 2013. Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein. PLoS Pathog 9:e1003494. http://dx.doi.org/10.1371/journal.ppat.1003494.
31. Li J, Lin S, Chen Q, Peng L, Zhai J, Liu Y, Yuan Z. 2010. Inhibition of hepatitis B virus replication by MyD88 involves accelerated degradation of pregenomic RNA and nuclear retention of pre-S/S RNAs. J Virol 84:6387-6399. http://dx.doi.org/10.1128/JVI.00236-10.
32. Rausa FM, Tan Y, Costa RH. 2003. Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding. Mol Cell Biol 23:437-449. http://dx.doi.org/10.1128/MCB.23.2.437-449.2003.
33. Tan Y, Yoshida Y, Hughes DE, Costa RH. 2006. Increased expression of hepatocyte nuclear factor 6 stimulates hepatocyte proliferation during mouse liver regeneration. Gastroenterology 130:1283-1300. http://dx.doi.org/10.1053/j.gastro.2006.01.010.
34. Tanaka M, Katayama F, Kato H, Tanaka H, Wang J, Qiao YL, Inoue M. 2011. Hepatitis B and C virus infection and hepatocellular carcinoma in China: a review of epidemiology and control measures. J Epidemiol 21: 401-416. http://dx.doi.org/10.2188/jea.JE20100190.
35. El-Serag HB. 2012. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 142:1264-1273.e1. http://dx.doi.org/10.1053/j.gastro.2011.12.061.