Decreased in vitro anticoagulant potency of Rivaroxaban and Apixaban in plasma from patients with cirrhosis

Hepatology

Volumn 61, Issue 4, 2015, Pages 1435-1436

  Potze, Wilma ^a   Adelmeijer, Jelle ^a   Lisman, Ton ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; APIXABAN; BLOOD CLOTTING FACTOR 10A INHIBITOR; RIVAROXABAN; THROMBOMODULIN; MORPHOLINE DERIVATIVE; THIOPHENE DERIVATIVE;

ANTICOAGULANT THERAPY; ANTICOAGULATION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; IN VITRO STUDY; LETTER; LIVER CIRRHOSIS; LIVER FUNCTION; PORTAL VEIN THROMBOSIS; PRIORITY JOURNAL; THROMBIN TIME; HUMAN; MALE; MESENTERIC VEIN; PORTAL VEIN; VENOUS THROMBOSIS;

ANTICOAGULANTS; HUMANS; MALE; MESENTERIC VEINS; MORPHOLINES; PORTAL VEIN; THIOPHENES; VENOUS THROMBOSIS;

EID: 84925371532     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27350     Document Type: Letter

References (6)

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4. Lisman T, Kamphuisen PW, Northup PG, Porte RJ. Established and new-generation antithrombotic drugs in patients with cirrhosis-possibilities and caveats. J Hepatol 2013;59:358-366.
5. Potze W, Arshad F, Adelmeijer J, Blokzijl H, van den Berg AP, Meijers JC, et al. Differential in vitro inhibition of thrombin generation by anticoagulant drugs in plasma from patients with cirrhosis. PLoS One 2014;9:e88390.
6. Potze W, Arshad F, Adelmeijer J, Blokzijl H, van den Berg AP, Porte RJ, et al. Routine coagulation assays underestimate levels of antithrombin-dependent drugs but not of direct anticoagulant drugs in plasma from patients with cirrhosis. Br J Haematol 2013;163:666-673.