Routine coagulation assays underestimate levels of antithrombin-dependent drugs but not of direct anticoagulant drugs in plasma from patients with cirrhosis

British Journal of Haematology

Volumn 163, Issue 5, 2013, Pages 666-673

  Potze, Wilma ^a   Arshad, Freeha ^a   Adelmeijer, Jelle ^a   Blokzijl, Hans ^a   van den Berg, Arie P ^a   Porte, Robert J ^a   Lisman, Ton ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Anti Xa assay; Anticoagulants; Antithrombin; Cirrhosis; Coagulation

Indexed keywords

ANTITHROMBIN; DABIGATRAN; ENOXAPARIN; FONDAPARINUX; HEPARIN; RIVAROXABAN;

ADULT; ARTICLE; BLOOD CLOTTING TEST; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG MONITORING; FEMALE; HUMAN; IN VITRO STUDY; INTERNATIONAL NORMALIZED RATIO; LIVER CIRRHOSIS; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RELIABILITY;

ANTI-XA ASSAY; ANTICOAGULANTS; ANTITHROMBIN; CIRRHOSIS; COAGULATION;

ANTICOAGULANTS; ANTITHROMBINS; BENZIMIDAZOLES; BETA-ALANINE; BLOOD COAGULATION; BLOOD COAGULATION TESTS; DIAGNOSTIC TESTS, ROUTINE; DRUG MONITORING; FACTOR XA; FALSE NEGATIVE REACTIONS; FEMALE; HEPARIN; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; MORPHOLINES; POLYSACCHARIDES; PROTHROMBIN; SENSITIVITY AND SPECIFICITY; THIOPHENES; THROMBOPHILIA;

EID: 84887516069     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12593     Document Type: Article

References (19)

1. Bechmann, L.P., Sichau, M., Wichert, M., Gerken, G., Kroger, K. & Hilgard, P. (2011) Low-molecular-weight heparin in patients with advanced cirrhosis. Liver International: Official Journal of the International Association for the Study of the Liver, 31, 75-82.
2. Delgado, M.G., Seijo, S., Yepes, I., Achecar, L., Catalina, M.V., Garcia-Criado, A., Abraldes, J.G., de la Pena, J., Banares, R., Albillos, A., Bosch, J. & Garcia-Pagan, J.C. (2012) Efficacy and safety of anticoagulation on patients with cirrhosis and portal vein thrombosis. Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association, 10, 776-783.
3. Durand, F. & Valla, D. (2008) Assessment of prognosis of cirrhosis. Seminars in Liver Disease, 28, 110-122.
4. Holm, H.A., Abildgaard, U., Larsen, M.L. & Kalvenes, S. (1987) Monitoring of heparin therapy: should heparin assays also reflect the patient's antithrombin concentration? Thrombosis Research, 46, 669-675.
5. Kuhle, S., Lau, A., Bajzar, L., Vegh, P., Halton, J., Cherrick, I., Anderson, R., Desai, S., McCusker, P., Wu, J., Abshire, T., Mahoney, D. & Mitchell, L. (2006) Comparison of the anticoagulant effect of a direct thrombin inhibitor and a low molecular weight heparin in an acquired antithrombin deficiency in children with acute lymphoblastic leukaemia treated with L-asparaginase: an in vitro study. British Journal of Haematology, 134, 526-531.
6. Lehman, C.M., Rettmann, J.A., Wilson, L.W. & Markewitz, B.A. (2006) Comparative performance of three anti-factor xa heparin assays in patients in a medical intensive care unit receiving intravenous, unfractionated heparin. American Journal of Clinical Pathology, 126, 416-421.
7. Lisman, T. & Porte, R.J. (2010) Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences. Blood, 116, 878-885.
8. Lisman, T. & Porte, R.J. (2011) Towards a rational use of low-molecular-weight heparin in patients with cirrhosis. Liver International: Official Journal of the International Association for the Study of the Liver, 31, 1063-3231.
9. Lisman, T., Caldwell, S.H., Burroughs, A.K., Northup, P.G., Senzolo, M., Stravitz, R.T., Tripodi, A., Trotter, J.F., Valla, D.C., Porte, R.J. & Coagulation in Liver Disease Study Group. (2010) Hemostasis and thrombosis in patients with liver disease: the ups and downs. Journal of Hepatology, 53, 362-371.
10. Lisman, T., Kamphuisen, P.W., Northup, P.G. & Porte, R.J. (2013) Established and new-generation antithrombotic drugs in patients with cirrhosis - possibilities and caveats. Journal of Hepatology, 59, 358-366.
11. Northup, P.G., Sundaram, V., Fallon, M.B., Reddy, K.R., Balogun, R.A., Sanyal, A.J., Anstee, Q.M., Hoffman, M.R., Ikura, Y., Caldwell, S.H. & Coagulation in Liver Disease Group. (2008) Hypercoagulation and thrombophilia in liver disease. Journal of Thrombosis and Haemostasis: JTH, 6, 2-9.
12. Porte, R.J., Lisman, T., Tripodi, A., Caldwell, S.H., Trotter, J.F. & Coagulation in Liver Disease Study Group. (2010) The international normalized ratio (INR) in the MELD score: problems and solutions. American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 10, 1349-1353.
13. Potze, W., Arshad, F., Adelmeijer, J., Blokzijl, H., van den Berg, A.P., Meijers, J.C.M., Porte, R.J. & Lisman, T. (2013) Increased anticoagulant response to drugs targeting thrombin, but not to drugs targeting FXa, in plasma from patients with cirrhosis. Journal of Thrombosis and Haemostasis, 11(Suppl. 2), 57.
14. Schmidt, B., Mitchell, L., Ofosu, F. & Andrew, M. (1988) Standard assays underestimate the concentration of heparin in neonatal plasma. The Journal of Laboratory and Clinical Medicine, 112, 641-643.
15. Schulman, S. & Crowther, M.A. (2012) How I treat with anticoagulants in 2012: new and old anticoagulants, and when and how to switch. Blood, 119, 3016-3023.
16. Senzolo, M., Rodriguez-Castro, K.I., Rossetto, V., Radu, C., Gavasso, S., Carraro, P., Zerbinati, P., Sartori, M.T. & Simioni, P. (2012) Increased anticoagulant response to low-molecular-weight heparin in plasma from patients with advanced cirrhosis. Journal of Thrombosis and Haemostasis: JTH, 10, 1823-1829.
17. Tripodi, A. & Mannucci, P.M. (2011) The coagulopathy of chronic liver disease. The New England Journal of Medicine, 365, 147-156.
18. Tripodi, A., Anstee, Q.M., Sogaard, K.K., Primignani, M. & Valla, D.C. (2011) Hypercoagulability in cirrhosis: causes and consequences. Journal of Thrombosis and Haemostasis: JTH, 9, 1713-1723.
19. Villa, E., Camma, C., Marietta, M., Luongo, M., Critelli, R., Colopi, S., Tata, C., Zecchini, R., Gitto, S., Petta, S., Lei, B., Bernabucci, V., Vukotic, R., De Maria, N., Schepis, F., Karampatou, A., Caporali, C., Simoni, L., Del Buono, M., Zambotto, B., Turola, E., Fornaciari, G., Schianchi, S., Ferrari, A. & Valla, D. (2012) Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis. Gastroenterology, 143, 1253-1260.