NDM-1-producing Enterobacteriaceae in a teaching hospital in Shanghai, China: IncX3-type plasmids may contribute to the dissemination of blaNDM-1

International Journal of Infectious Diseases

Volumn 34, Issue , 2015, Pages 8-13

  Qu, Hongping ^a   Wang, Xiaoli ^a   Ni, Yuxing ^a   Liu, Jialin ^a   Tan, Ruoming ^a   Huang, Jie ^a   Li, Lei ^a   Sun, Jingyong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Carbapenem resistant Enterobacteriaceae; Dissemination; NDM 1; Plasmid

Indexed keywords

AMIKACIN; CARBAPENEMASE; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CEFTRIAXONE; ERTAPENEM; GENTAMICIN; IMIPENEM; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; TIGECYCLINE; BACTERIAL PROTEIN; BETA LACTAMASE; BETA-LACTAMASE NDM-1;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CARBAPENEM RESISTANT ENTEROBACTERIACEAE; CHINA; CONJUGATION; ENTEROBACTERIACEAE; GENETIC TRAIT; HUMAN; KLEBSIELLA PNEUMONIAE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; POLYMERASE CHAIN REACTION; PULSED FIELD GEL ELECTROPHORESIS; RAOULTELLA PLANTICOLA; SOUTHERN BLOTTING; TEACHING HOSPITAL; UNITED ARAB EMIRATES; BACTERIUM CONJUGATION; CROSS INFECTION; ENTEROBACTERIACEAE INFECTIONS; GENE ORDER; GENETICS; ISOLATION AND PURIFICATION; KLEBSIELLA INFECTIONS; MALE; MICROBIOLOGY; YOUNG ADULT;

BACTERIAL PROTEINS; BETA-LACTAMASES; CHINA; CONJUGATION, GENETIC; CROSS INFECTION; ELECTROPHORESIS, GEL, PULSED-FIELD; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; GENE ORDER; HOSPITALS, TEACHING; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; PLASMIDS; UNITED ARAB EMIRATES; YOUNG ADULT;

EID: 84925356906     PISSN: 12019712     EISSN: 18783511     Source Type: Journal    
DOI: 10.1016/j.ijid.2015.02.020     Document Type: Article

References (28)

1. Gupta N., Limbago B.M., Patel J.B., Kallen A.J. Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis 2011, 53:60-67.
2. Yong D., Toleman M.A., Giske C.G., Cho H.S., Sundman K., Lee K., et al. Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother 2009, 53:5046-5054.
3. Nordmann P., Naas T., Poirel L. Global spread of Carbapenemase-producing Enterobacteriaceae. Emerg Infect Dis 2011, 17:1791-1798.
4. Chen Y., Zhou Z., Jiang Y., Yu Y. Emergence of NDM-1-producing Acinetobacter baumannii in China. J Antimicrob Chemother 2011, 66:1255-1259.
5. Hu L., Zhong Q., Tu J., Xu Y., Qin Z., Parsons C., et al. Emergence of blaNDM-1 among Klebsiella pneumoniae ST15 and novel ST1031 clinical isolates in China. Diagn Microbiol Infect Dis 2013, 75:373-376.
6. Liu Z., Li W., Wang J., Pan J., Sun S., Yu Y., et al. Identification and characterization of the first Escherichia coli strain carrying NDM-1 gene in China. PLoS One 2013, 8:e66666.
7. Fu Y., Du X., Ji J., Chen Y., Jiang Y., Yu Y. Epidemiological characteristics and genetic structure of blaNDM-1 in non-baumannii Acinetobacter spp. in China. J Antimicrob Chemother 2012, 67:2114-2122.
8. Wang X., Xu X., Li Z., Chen H., Wang Q., Yang P., et al. An Outbreak of a Nosocomial NDM-1-Producing Klebsiella pneumoniae ST147 at a Teaching Hospital in Mainland China. Microb Drug Resist 2013.
9. Li J., Lan R., Xiong Y., Ye C., Yuan M., Liu X., et al. Sequential isolation in a patient of Raoultella planticola and Escherichia coli bearing a novel ISCR1 element carrying blaNDM-1. PLoS One 2014, 9:e89893.
10. Zhang X., Lou D., Xu Y., Shang Y., Li D., Huang X., et al. First identification of coexistence of blaNDM-1 and blaCMY-42 among Escherichia coli ST167 clinical isolates. BMC Microbiol 2013, 13:282.
11. Nordmann P., Poirel L., Walsh T.R., Livermore D.M. The emerging NDM carbapenemases. Trends Microbiol 2011, 19:588-595.
12. Bushnell G., Mitrani-Gold F., Mundy L.M. Emergence of New Delhi metallo-beta-lactamase type 1-producing enterobacteriaceae and non-enterobacteriaceae: global case detection and bacterial surveillance. Int J Infect Dis 2013, 17:e325-e333.
13. Kumarasamy K.K., Toleman M.A., Walsh T.R., Bagaria J., Butt F., Balakrishnan R., et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis 2010, 10:597-602.
14. Patel G., Bonomo R.A. "Stormy waters ahead": global emergence of carbapenemases. Front Microbiol 2013, 4:48.
15. Pfeifer Y., Witte W., Holfelder M., Busch J., Nordmann P., Poirel L. NDM-1-producing Escherichia coli in Germany. Antimicrob Agents Chemother 2011, 55:1318-1319.
16. CLSI. Performance Standards for Antimicrobial Susceptibility Testing: Twentieth Informational Supplement M100-S20.CLSI, Wayne, PA, USA, 2010.
17. Li B., Sun J.Y., Liu Q.Z., Han L.Z., Huang X.H., Ni Y.X. First report of Klebsiella oxytoca strain coproducing KPC-2 and IMP-8 carbapenemases. Antimicrob Agents Chemother 2011, 55:2937-2941.
18. Ewing B., Hillier L., Wendl M.C., Green P. Base-calling of automated sequencer traces using phred. I. Accuracy assessment. Genome Res 1998, 8:175-185.
19. Besemer J., Lomsadze A., Borodovsky M. GeneMarkS: a self-training method for prediction of gene starts in microbial genomes. Implications for finding sequence motifs in regulatory regions. Nucleic Acids Res 2001, 29:2607-2618.
20. Huang T.W., Wang J.T., Lauderdale T.L., Liao T.L., Lai J.F., Tan M.C., et al. Complete sequences of two plasmids in a blaNDM-1-positive Klebsiella oxytoca isolate from Taiwan. Antimicrob Agents Chemother 2013, 57:4072-4076.
21. Golubov A., Neubauer H., Nolting C., Heesemann J., Rakin A. Structural organization of the pFra virulence-associated plasmid of rhamnose-positive Yersinia pestis. Infect Immun 2004, 72:5613-5621.
22. Ho Pak-Leung, Li Zhen, Lo Wai-U, Cheung Yuk-Yam, Chi-Ho Lin, Pak-Chung Sham, et al. Identification and characterization of a novel incompatibility group X3 plasmid carrying blaNDM-1 in Enterobacteriaceaeisolates with epidemiological links to multiple geographical areas in China. Emerging Microbes and Infections 2012,1.
23. Giske C.G., Froding I., Hasan C.M., Turlej-Rogacka A., Toleman M., Livermore D., et al. Diverse sequence types of Klebsiella pneumoniae contribute to the dissemination of blaNDM-1 in India, Sweden, and the United Kingdom. Antimicrob Agents Chemother 2012, 56:2735-2738.
24. Hu L., Zhong Q., Shang Y., Wang H., Ning C., Li Y., et al. The prevalence of carbapenemase genes and plasmid-mediated quinolone resistance determinants in carbapenem-resistant Enterobacteriaceae from five teaching hospitals in central China. Epidemiol Infect 2013, 1-6.
25. Du X.X., Wang J.F., Fu Y., Zhao F., Chen Y., Wang H.P., et al. Genetic characteristics of blaNDM-1-positive plasmid in Citrobacter freundii isolate separated from a clinical infectious patient. J Med Microbiol 2013, 62:1332-1337.
26. Sonnevend A., Al Baloushi A., Ghazawi A., Hashmey R., Girgis S., Hamadeh M.B., et al. Emergence and spread of NDM-1 producer Enterobacteriaceae with contribution of IncX3 plasmids in the United Arab Emirates. J Med Microbiol 2013, 62:1044-1050.
27. Qi Y., Wei Z., Ji S., Du X., Shen P., Yu Y. ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China. J Antimicrob Chemother 2011, 66:307-312.
28. Poirel L., Dortet L., Bernabeu S., Nordmann P. Genetic features of blaNDM-1-positive Enterobacteriaceae. Antimicrob Agents Chemother 2011, 55:5403-5407.