A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution

Circulation: Cardiovascular Genetics

Volumn 7, Issue 5, 2014, Pages 659-666

  Hartney, John M ^a,b   Stidham, Timothy ^c   Goldstrohm, David A ^a   Oberley Deegan, Rebecca E ^a   Weaver, Michael R ^a   Valnickova Hansen, Zuzana ^d   Scavenius, Carsten ^d   Benninger, Richard K P ^c   Leahy, Katelyn F ^a   Johnson, Richard ^c   Gally, Fabienne ^a   Kosmider, Beata ^a   Zimmermann, Angela K ^e   Enghild, Jan J ^d   Nozik Grayck, Eva ^c   Bowler, Russell P ^a  

^a DEPARTMENT OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d AARHUS UNIVERSITY   (Denmark)

^e AIX MARSEILLE UNIVERSITÉ   (France)

Author keywords

Cardiovascular diseases; Hypertension; Lung; Pulmonary

Indexed keywords

4 HYDROXYNONENAL; ALPHA SMOOTH MUSCLE ACTIN; EXTRACELLULAR SUPEROXIDE DISMUTASE; LIPOPOLYSACCHARIDE; ANTIOXIDANT; ARGININE; GLYCINE; HEPARIN; SEPHAROSE; SOD3 PROTEIN, HUMAN; SOD3 PROTEIN, MOUSE; SUPEROXIDE DISMUTASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL INJURY; CARDIOPULMONARY DISEASE; CARDIOVASCULAR DISEASE; CHRONIC HYPOXIC PULMONARY HYPERTENSION; CONTROLLED STUDY; DNA SEQUENCE; EMBRYO; ENZYME ACTIVITY; EXON; EXTRACELLULAR FLUID; EXTRACELLULAR MATRIX; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; LUNG BLOOD VESSEL; LUNG DISEASE; LUNG INJURY; LUNG PARENCHYMA; MOUSE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROGENY; PROTEIN LOCALIZATION; PULMONARY HYPERTENSION; RISK FACTOR; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; TISSUE DISTRIBUTION; VASCULAR TISSUE; WESTERN BLOTTING; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; C57BL MOUSE; CHEMISTRY; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; LUNG; METABOLISM; TRANSGENIC MOUSE;

ANIMALS; ANTIOXIDANTS; ARGININE; BRONCHOALVEOLAR LAVAGE FLUID; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLYCINE; HEPARIN; HUMANS; HYPERTENSION, PULMONARY; LUNG; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SEPHAROSE; SEQUENCE ANALYSIS, DNA; SUPEROXIDE DISMUTASE;

EID: 84925354176     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.113.000504     Document Type: Article

References (30)

1. Petersen SV, Olsen DA, Kenney JM, Oury TD, Valnickova Z, Thøgersen IB, et al. The high concentration of Arg213→Gly extracellular superoxide dismutase (EC-SOD) in plasma is caused by a reduction of both heparin and collagen affinities. Biochem J. 2005;385(Pt 2):427-432
2. Oury TD, Crapo JD, Valnickova Z, Enghild JJ. Human extracellular superoxide dismutase is a tetramer composed of two disulphide-linked dimers: A simplified, high-yield purification of extracellular superoxide dismutase. Biochem J. 1996;317(Pt 1):51-57
3. Nozik-Grayck E, Suliman HB, Majka S, Albietz J, Van Rheen Z, Roush K, et al. Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol. 2008;295:L422-L430
4. Bowler RP, Nicks M, Warnick K, Crapo JD. Role of extracellular superoxide dismutase in bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2002;282:L719-L726
5. Oury TD, Schaefer LM, Fattman CL, Choi A, Weck KE, Watkins SC. Depletion of pulmonary EC-SOD after exposure to hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2002;283:L777-L784
6. Villegas LR, Kluck D, Field C, Oberley-Deegan RE, Woods C, Yeager ME, et al. Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxiainduced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome. Antioxid Redox Signal. 2013;18:1753-1764
7. Hartney JM, Brown J, Chu HW, Chang LY, Pelanda R, Torres RM. Arhgef1 regulates alpha5beta1 integrin-mediated matrix metalloproteinase expression and is required for homeostatic lung immunity. Am J Pathol. 2010;176:1157-1168
8. Waypa GB, Chandel NS, Schumacker PT. Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ Res. 2001;88:1259-1266
9. Lim RS, Kratzer A, Barry NP, Miyazaki-Anzai S, Miyazaki M, Mantulin WW, et al. Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice. J Lipid Res. 2010;51:1729-1737
10. Richens TR, Linderman DJ, Horstmann SA, Lambert C, Xiao YQ, Keith RL, et al. Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA. Am J Respir Crit Care Med. 2009;179:1011-1021
11. Bowler RP, Barnes PJ, Crapo JD. The role of oxidative stress in chronic obstructive pulmonary disease. COPD. 2004;1:255-277
12. Jung O, Marklund SL, Geiger H, Pedrazzini T, Busse R, Brandes RP. Extracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: In vivo and ex vivo evidence from ecSOD-deficient mice. Circ Res. 2003;93:622-629
13. Bowler RP, Arcaroli J, Crapo JD, Ross A, Slot JW, Abraham E. Extracellular superoxide dismutase attenuates lung injury after hemorrhage. Am J Respir Crit Care Med. 2001;164:290-294
14. Bowler RP, Arcaroli J, Abraham E, Patel M, Chang LY, Crapo JD. Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2003;284:L680-L687
15. Bowler RP, Nicks M, Tran K, Tanner G, Chang LY, Young SK, et al. Extracellular superoxide dismutase attenuates lipopolysaccharide-induced neutrophilic inflammation. Am J Respir Cell Mol Biol. 2004;31:432-439
16. Tollefson AK, Oberley-Deegan RE, Butterfield KT, Nicks ME, Weaver MR, Remigio LK, et al. Endogenous enzymes (NOX and ECSOD) regulate smoke-induced oxidative stress. Free Radic Biol Med. 2010;49:1937-1946
17. Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, et al. Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc Natl Acad Sci U S A. 2010;107:15571-15576
18. Ghio AJ, Suliman HB, Carter JD, Abushamaa AM, Folz RJ. Overexpression of extracellular superoxide dismutase decreases lung injury after exposure to oil fly ash. Am J Physiol Lung Cell Mol Physiol. 2002;283:L211-L218
19. Kang SK, Rabbani ZN, Folz RJ, Golson ML, Huang H, Yu D, et al. Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury. Int J Radiat Oncol Biol Phys. 2003;57:1056-1066
20. Oury TD, Ho YS, Piantadosi CA, Crapo JD. Extracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity. Proc Natl Acad Sci U S A. 1992;89:9715-9719
21. Hartney T, Birari R, Venkataraman S, Villegas L, Martinez M, Black SM, et al. Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia. PLoS One. 2011;6:e27531
22. Xu Y, Stenmark KR, Das M, Walchak SJ, Ruff LJ, Dempsey EC. Pulmonary artery smooth muscle cells from chronically hypoxic neonatal calves retain fetal-like and acquire new growth properties. Am J Physiol. 1997;273(1 Pt 1):L234-L245
23. Juul K, Tybjaerg-Hansen A, Marklund S, Lange P, Nordestgaard BG. Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006;173:858-864
24. Young RP, Hopkins R, Black PN, Eddy C, Wu L, Gamble GD, et al. Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function. Thorax. 2006;61:394-399
25. Siedlinski M, van Diemen CC, Postma DS, Vonk JM, Boezen HM. Superoxide dismutases, lung function and bronchial responsiveness in a general population. Eur Respir J. 2009;33:986-992
26. Dahl M, Bowler RP, Juul K, Crapo JD, Levy S, Nordestgaard BG. Superoxide dismutase 3 polymorphism associated with reduced lung function in two large populations. Am J Respir Crit Care Med. 2008;178:906-912
27. Sørheim IC, DeMeo DL, Washko G, Litonjua A, Sparrow D, Bowler R, et al; International COPD Genetics Network Investigators. Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD. COPD. 2010;7:262-268
28. Marklund SL, Nilsson P, Israelsson K, Schampi I, Peltonen M, Asplund K. Two variants of extracellular-superoxide dismutase: Relationship to cardiovascular risk factors in an unselected middle-aged population. J Intern Med. 1997;242:5-14
29. Juul K, Tybjaerg-Hansen A, Marklund S, Heegaard NH, Steffensen R, Sillesen H, et al. Genetically reduced antioxidative protection and increased ischemic heart disease risk: The Copenhagen City Heart Study. Circulation. 2004;109:59-65
30. Sandström J, Nilsson P, Karlsson K, Marklund SL. 10-fold increase in human plasma extracellular superoxide dismutase content caused by a mutation in heparin-binding domain. J Biol Chem. 1994;269:19163-19166.