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Volumn 68, Issue 4, 2015, Pages 460-465

P < 5 × 10-8 has emerged as a standard of statistical significance for genome-wide association studies

Author keywords

Evaluation studies as topic; False discovery rate; Genome wide association study; Multiple testing; Significance thresholds; Validation studies

Indexed keywords

ARTICLE; CONSENSUS; DATA BASE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; HUMAN; PRIORITY JOURNAL; PROBABILITY; SAMPLE SIZE; SINGLE NUCLEOTIDE POLYMORPHISM; STANDARD; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SYSTEMATIC REVIEW; PROCEDURES;

EID: 84925350670     PISSN: 08954356     EISSN: 18785921     Source Type: Journal    
DOI: 10.1016/j.jclinepi.2015.01.001     Document Type: Article
Times cited : (51)

References (20)
  • 1
    • 77955657343 scopus 로고    scopus 로고
    • Expectations, validity, and reality in omics
    • J.P.A. Ioannidis Expectations, validity, and reality in omics J Clin Epidemiol 63 2010 945 949
    • (2010) J Clin Epidemiol , vol.63 , pp. 945-949
    • Ioannidis, J.P.A.1
  • 3
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • L.A. Hindorff, P. Sethupathy, H.A. Junkins, E.M. Ramos, J.P. Mehta, and F.S. Collins et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits Proc Natl Acad Sci U S A 106 2009 9362 9367
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3    Ramos, E.M.4    Mehta, J.P.5    Collins, F.S.6
  • 4
    • 67349252770 scopus 로고    scopus 로고
    • Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement
    • J. Little, J.P.T. Higgins, J.P.A. Ioannidis, D. Moher, F. Gagnon, and E. von Elm et al. Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement J Clin Epidemiol 62 2009 597 608.e4
    • (2009) J Clin Epidemiol , vol.62 , pp. 597.e4-608.e4
    • Little, J.1    Higgins, J.P.T.2    Ioannidis, J.P.A.3    Moher, D.4    Gagnon, F.5    Von Elm, E.6
  • 5
    • 84876176442 scopus 로고    scopus 로고
    • Challenges in reproducibility of genetic association studies: lessons learned from the obesity field
    • A. Li, and D. Meyre Challenges in reproducibility of genetic association studies: lessons learned from the obesity field Int J Obes 2013 37 2005 559 567
    • (2005) Int J Obes , vol.2013 , Issue.37 , pp. 559-567
    • Li, A.1    Meyre, D.2
  • 6
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • N. Risch, and K. Merikangas The future of genetic studies of complex human diseases Science 273 1996 1516 1517
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 7
    • 73149103718 scopus 로고    scopus 로고
    • Prioritizing GWAS results: a review of statistical methods and recommendations for their application
    • R.M. Cantor, K. Lange, and J.S. Sinsheimer Prioritizing GWAS results: a review of statistical methods and recommendations for their application Am J Hum Genet 86 2010 6 22
    • (2010) Am J Hum Genet , vol.86 , pp. 6-22
    • Cantor, R.M.1    Lange, K.2    Sinsheimer, J.S.3
  • 8
    • 65249164859 scopus 로고    scopus 로고
    • Validating, augmenting and refining genome-wide association signals
    • J.P.A. Ioannidis, G. Thomas, and M.J. Daly Validating, augmenting and refining genome-wide association signals Nat Rev Genet 10 2009 318 329
    • (2009) Nat Rev Genet , vol.10 , pp. 318-329
    • Ioannidis, J.P.A.1    Thomas, G.2    Daly, M.J.3
  • 9
    • 31744435871 scopus 로고    scopus 로고
    • Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies
    • A.D. Skol, L.J. Scott, G.R. Abecasis, and M. Boehnke Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies Nat Genet 38 2006 209 213
    • (2006) Nat Genet , vol.38 , pp. 209-213
    • Skol, A.D.1    Scott, L.J.2    Abecasis, G.R.3    Boehnke, M.4
  • 11
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Y. Benjamini, and Y. Hochberg Controlling the false discovery rate: a practical and powerful approach to multiple testing J R Stat Soc Ser B Methodol 1995 289 300
    • (1995) J R Stat Soc Ser B Methodol , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 12
    • 42249087793 scopus 로고    scopus 로고
    • Estimation of significance thresholds for genomewide association scans
    • F. Dudbridge, and A. Gusnanto Estimation of significance thresholds for genomewide association scans Genet Epidemiol 32 2008 227 234
    • (2008) Genet Epidemiol , vol.32 , pp. 227-234
    • Dudbridge, F.1    Gusnanto, A.2
  • 14
    • 43249125992 scopus 로고    scopus 로고
    • Estimation of the multiple testing burden for genomewide association studies of nearly all common variants
    • I. Pe'er, R. Yelensky, D. Altshuler, and M.J. Daly Estimation of the multiple testing burden for genomewide association studies of nearly all common variants Genet Epidemiol 32 2008 381 385
    • (2008) Genet Epidemiol , vol.32 , pp. 381-385
    • Pe'er, I.1    Yelensky, R.2    Altshuler, D.3    Daly, M.J.4
  • 15
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Wellcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 447 2007 661 678
    • (2007) Nature , vol.447 , pp. 661-678
  • 16
    • 0035992248 scopus 로고    scopus 로고
    • Empirical Bayes methods and false discovery rates for microarrays
    • B. Efron, and R. Tibshirani Empirical Bayes methods and false discovery rates for microarrays Genet Epidemiol 23 2002 70 86
    • (2002) Genet Epidemiol , vol.23 , pp. 70-86
    • Efron, B.1    Tibshirani, R.2
  • 17
    • 66149185456 scopus 로고    scopus 로고
    • Genomewide association studies: history, rationale, and prospects for psychiatric disorders
    • Psychiatric GWAS Consortium Coordinating Committee S. Cichon, N. Craddock, M. Daly, S.V. Faraone, and P.V. Gejman et al. Genomewide association studies: history, rationale, and prospects for psychiatric disorders Am J Psychiatry 166 2009 540 556
    • (2009) Am J Psychiatry , vol.166 , pp. 540-556
    • Cichon, S.1    Craddock, N.2    Daly, M.3    Faraone, S.V.4    Gejman, P.V.5
  • 19
    • 84863338087 scopus 로고    scopus 로고
    • Genome-wide significance project. What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations
    • O.A. Panagiotou, and J.P.A. Ioannidis Genome-wide significance project. What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations Int J Epidemiol 41 2012 273 286
    • (2012) Int J Epidemiol , vol.41 , pp. 273-286
    • Panagiotou, O.A.1    Ioannidis, J.P.A.2
  • 20
    • 84897507662 scopus 로고    scopus 로고
    • Scientific reporting is suboptimal for aspects that characterize genetic risk prediction studies: a review of published articles based on the Genetic RIsk Prediction Studies statement
    • A.I. Iglesias, R. Mihaescu, J.P.A. Ioannidis, M.J. Khoury, J. Little, and C.M. van Duijn et al. Scientific reporting is suboptimal for aspects that characterize genetic risk prediction studies: a review of published articles based on the Genetic RIsk Prediction Studies statement J Clin Epidemiol 67 2014 487 499
    • (2014) J Clin Epidemiol , vol.67 , pp. 487-499
    • Iglesias, A.I.1    Mihaescu, R.2    Ioannidis, J.P.A.3    Khoury, M.J.4    Little, J.5    Van Duijn, C.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.