DNAM-1-based chimeric antigen receptors enhance T cell effector function and exhibit in vivo efficacy against melanoma

Cancer Immunology, Immunotherapy

Volumn 64, Issue 4, 2015, Pages 409-418

  Wu, Ming Ru ^a   Zhang, Tong ^a   Alcon, Andre ^a   Sentman, Charles L ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Adoptive T cell therapy; CAR; Gene therapy; Immunotherapy; Melanoma

Indexed keywords

CHIMERIC ANTIGEN RECEPTOR; DNAM 1 RECEPTOR; NATURAL KILLER CELL RECEPTOR; NECTIN 1; NECTIN 2; RETROVIRUS VECTOR; UNCLASSIFIED DRUG; CD226 ANTIGEN; CD3 ANTIGEN; CD3 ANTIGEN, ZETA CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR; MESSENGER RNA; T LYMPHOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN RECOGNITION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; IN VITRO STUDY; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TUMOR VOLUME; ANIMAL; C57BL MOUSE; CYTOTOXICITY; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD3; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; BLOTTING, WESTERN; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; MELANOMA; MICE; MICE, INBRED C57BL; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 84925339298     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-014-1648-2     Document Type: Article

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