Selective disruption of the AKAP signaling complexes

Methods in Molecular Biology

Volumn 1294, Issue , 2015, Pages 137-150

  Kennedy, Eileen J ^a   Scott, John D ^a  

^a NONE

Author keywords

AKAP; AKAP IS; Anchoring proteins; cAMP signaling; Compartmentalization; Ht31; Protein kinase A (PKA); Rselect; RIAD; STAD

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; BUCLADESINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; ISOBUTYLMETHYLXANTHINE; ISOPRENALINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PEPTIDE DERIVATIVE; PROSTAGLANDIN E2;

ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CELL ORGANELLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; METHODOLOGY; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SECOND MESSENGER; SIGNAL TRANSDUCTION; SYNTHESIS;

EID: 84925310314     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-2537-7_11     Document Type: Article

References (69)

1. Scott JD, Pawson T (2009) Cell signaling in space and time: where proteins come together and when they're apart. Science 326: 1220-1224. doi: 10.1126/science.1175668
2. Carr DW, Stofko-Hahn RE, Fraser ID et al (1991) Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif. J Biol Chem 266:14188-14192
3. Newlon MG, Roy M, Morikis D et al (2001) A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes. EMBO J 20:1651-1662. doi: 10.1093/emboj/20.7.1651
4. Gold MG, Lygren B, Dokurno P et al (2006) Molecular basis of AKAP specificity for PKA regulatory subunits. Mol Cell 24:383-395. doi: 10.1016/j.molcel.2006.09.006
5. Welch EJ, Jones BW, Scott JD (2010) Networking with AKAPs: context-dependent regulation of anchored enzymes. Mol Interv 10:86-97. doi: 10.1124/mi.10.2.6
6. Skroblin P, Grossmann S, Schafer G et al (2010) Mechanisms of protein kinase A anchoring. Int Rev Cell Mol Biol 283:235-330. doi: 10.1016/S1937-6448(10)83005-9
7. Dessauer CW (2009) Adenylyl cyclase - A-kinase anchoring protein complexes: the next dimension in cAMP signaling. Mol Pharmacol 76:935-941. doi: 10.1124/mol.109.059345
8. Sanderson JL, Dell'Acqua ML (2011) AKAP signaling complexes in regulation of excitatory synaptic plasticity. Neuroscientist 17:321-336. doi: 10.1177/1073858410384740
9. Diviani D, Dodge-Kafka KL, Li J et al (2011) A-kinase anchoring proteins: scaffolding proteins in the heart. Am J Physiol Heart Circ Physiol 301:H1742-H1753. doi: 10.1152/ ajpheart.00569.2011
10. Klauck TM, Faux MC, Labudda K et al (1996) Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Science 271:1589-1592
11. Coghlan VM, Hausken ZE, Scott JD (1995) Subcellular targeting of kinases and phosphatases by association with bifunctional anchoring proteins. Biochem Soc Trans 23:592-596
12. Dodge KL, Khouangsathiene S, Kapiloff MS et al (2001) mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module. EMBO J 20:1921-1930. doi: 10.1093/emboj/20.8.1921
13. Tasken KA, Collas P, Kemmner WA et al (2001) Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area. J Biol Chem 276:21999-22002. doi: 10.1074/jbc.C000911200
14. Bauman AL, Soughayer J, Nguyen BT et al (2006) Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes. Mol Cell 23:925-931. doi: 10.1016/j.molcel.2006.07.025
15. Taylor SS, Yang J, Wu J et al (2004) PKA: a portrait of protein kinase dynamics. Biochim Biophys Acta 1697:259-269. doi: 10.1016/j. bbapap.2003.11.029
16. Herberg FW, Maleszka A, Eide T et al (2000) Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding. J Mol Biol 298:329-339. doi: 10.1006/jmbi.2000.3662
17. Aye TT, Mohammed S, van den Toorn HW et al (2009) Selectivity in enrichment of cAMP- dependent protein kinase regulatory subunits type I and type II and their interactors using modified cAMP affinity resins. Mol Cell Proteomics 8:1016-1028. doi: 10.1074/ mcp. M800226-MCP200
18. Lester LB, Coghlan VM, Nauert B et al (1996) Cloning and characterization of a novel A-kinase anchoring protein. AKAP 220, association with testicular peroxisomes. J Biol Chem 271:9460-9465
19. Trotter KW, Fraser ID, Scott GK et al (1999) Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms. J Cell Biol 147:1481-1492
20. Huang LJ, Durick K, Weiner JA et al (1997) Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. J Biol Chem 272:8057-8064
21. Wang Y, Ho TG, Bertinetti D et al (2014) Isoform-selective disruption of AKAPlocalized PKA using hydrocarbon stapled peptides. ACS Chem Biol 9:635-642. doi: 10.1021/cb400900r
22. Scott JD, Dessauer CW, Tasken K (2013) Creating order from chaos: cellular regulation by kinase anchoring. Annu Rev Pharmacol Toxicol 53:187-210. doi: 10.1146/annurevpharmtox- 011112-140204
23. Carr DW, Hausken ZE, Fraser ID et al (1992) Association of the type II cAMP-dependent protein kinase with a human thyroid RIIanchoring protein. Cloning and characterization of the RII-binding domain. J Biol Chem 267:13376-13382
24. Vijayaraghavan S, Goueli SA, Davey MP et al (1997) Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility. J Biol Chem 272:4747-4752
25. Alto NM, Soderling SH, Hoshi N et al (2003) Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A 100:4445-4450. doi: 10.1073/pnas.0330734100
26. Faruque OM, Le-Nguyen D, Lajoix AD et al (2009) Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: a tool for studying the molecular roles of AKAP- mediated PKA subcellular anchoring. Am J Physiol Cell Physiol 296:C306-C316. doi: 10.1152/ajpcell.00216.2008
27. Hundsrucker C, Krause G, Beyermann M et al (2006) High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. Biochem J 396:297-306. doi: 10.1042/BJ20051970
28. Christian F, Szaszak M, Friedl S et al (2011) Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. J Biol Chem 286:9079-9096. doi: 10.1074/jbc.M110.160614
29. Schafer G, Milic J, Eldahshan A et al (2013) Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions. Angew Chem Int Ed Engl 52:12187-12191. doi: 10.1002/anie.201304686
30. Verdine GL, Hilinski GJ (2012) Stapled peptides for intracellular drug targets. Methods Enzymol 503:3-33. doi: 10.1016/ B978-0-12-396962-0.00001-X
31. Gold MG, Fowler DM, Means CK et al (2013) Engineering A-kinase anchoring protein (AKAP)-selective regulatory subunits of protein kinase A (PKA) through structure-based phage selection. J Biol Chem 288:17111-17121. doi: 10.1074/jbc.M112.447326
32. Burns-Hamuro LL, Ma Y, Kammerer S et al (2003) Designing isoform-specific peptide disruptors of protein kinase A localization. Proc Natl Acad Sci U S A 100:4072-4077. doi: 10.1073/pnas.2628038100
33. Carlson CR, Lygren B, Berge T et al (2006) Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor. J Biol Chem 281:21535-21545
34. Torheim EA, Jarnaess E, Lygren B et al (2009) Design of proteolytically stable RI-anchoring disruptor peptidomimetics for in vivo studies of anchored type I protein kinase A-mediated signalling. Biochem J 424:69-78. doi: 10.1042/ BJ20090933
35. Sarma GN, Kinderman FS, Kim C et al (2010) Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity. Structure 18:155-166
36. Jarnaess E, Ruppelt A, Stokka AJ et al (2008) Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I. J Biol Chem 283:33708-33718. doi: 10.1074/jbc.M804807200
37. Bhat SV, Bajwa BS, Dornauer H, de Souza NJ (1977) Structure and stereochemistry of new labdane diterpenoids from Coleus forskohlii Briq. Tetrahedron Lett 19:1669-1672
38. Seamon KB, Padgett W, Daly JW (1981) Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proc Natl Acad Sci U S A 78:3363-3367
39. Patel TB, Du Z, Pierre S et al (2001) Molecular biological approaches to unravel adenylyl cyclase signaling and function. Gene 269: 13-25
40. Premont RT, Matsuoka I, Mattei MG et al (1996) Identification and characterization of a widely expressed form of adenylyl cyclase. J Biol Chem 271:13900-13907
41. Dessauer CW, Scully TT, Gilman AG (1997) Interactions of forskolin and ATP with the cytosolic domains of mammalian adenylyl cyclase. J Biol Chem 272:22272-22277
42. Beavo JA, Rogers NL, Crofford OB et al (1970) Effects of xanthine derivatives on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activity. Mol Pharmacol 6:597-603
43. Omori K, Kotera J (2007) Overview of PDEs and their regulation. Circ Res 100:309-327. doi: 10.1161/01.RES.0000256354.95791.f1
44. Robison GA, Butcher RW, Sutherland EW (1968) Cyclic AMP. Annu Rev Biochem 37:149-174. doi: 10.1146/annurev. bi.37.070168.001053
45. Shear M, Insel PA, Melmon KL et al (1976) Agonist-specific refractoriness induced by isoproterenol. Studies with mutant cells. J Biol Chem 251:7572-7576
46. Sugimoto Y, Narumiya S (2007) Prostaglandin E receptors. J Biol Chem 282:11613-11617. doi: 10.1074/jbc.R600038200
47. Zeng L, An S, Goetzl EJ (1998) EP4/EP2 receptor-specific prostaglandin E2 regulation of interleukin-6 generation by human HSB.2 early T cells. J Pharmacol Exp Ther 286: 1420-1426
48. Schwede F, Maronde E, Genieser H et al (2000) Cyclic nucleotide analogs as biochemical tools and prospective drugs. Pharmacol Ther 87:199-226
49. Zorn M, Maronde E, Jastorff B et al (1993) Differential effects of two structurally related N6-substituted cAMP analogues on C6 glioma cells. Eur J Cell Biol 60:351-357
50. Beavo JA, Brunton LL (2002) Cyclic nucleotide research - still expanding after half a century. Nat Rev Mol Cell Biol 3:710-718. doi: 10.1038/nrm911
51. Walsh DA, Ashby CD, Gonzalez C et al (1971) Krebs EG: purification and characterization of a protein inhibitor of adenosine 3′,5′-monophosphate- dependent protein kinases. J Biol Chem 246:1977-1985
52. Dalton GD, Dewey WL (2006) Protein kinase inhibitor peptide (PKI): a family of endogenous neuropeptides that modulate neuronal cAMP-dependent protein kinase function. Neuropeptides 40:23-34. doi: 10.1016/j. npep.2005.10.002
53. Demaille JG, Peters KA, Fischer EH (1977) Isolation and properties of the rabbit skeletal muscle protein inhibitor of adenosine 3′,5′-monophosphate dependent protein kinases. Biochemistry 16:3080-3086
54. Scott JD, Fischer EH, Demaille JG et al (1985) Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMPdependent protein kinase. Proc Natl Acad Sci U S A 82:4379-4383
55. Scott JD, Fischer EH, Takio K et al (1985) Amino acid sequence of the heat-stable inhibitor of the cAMP-dependent protein kinase from rabbit skeletal muscle. Proc Natl Acad Sci U S A 82:5732-5736
56. Cheng HC, van Patten SM, Smith AJ et al (1985) An active twenty-amino-acid-residue peptide derived from the inhibitor protein of the cyclic AMP-dependent protein kinase. Biochem J 231:655-661
57. Scott JD, Glaccum MB, Fischer EH et al (1986) Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase. Proc Natl Acad Sci U S A 83:1613-1616
58. Glass DB, Cheng HC, Kemp BE et al (1986) Differential and common recognition of the catalytic sites of the cGMP-dependent and cAMP-dependent protein kinases by inhibitory peptides derived from the heat-stable inhibitor protein. J Biol Chem 261:12166-12171
59. Cheng HC, Kemp BE, Pearson RB et al (1986) A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J Biol Chem 261:989-992
60. Reed J, De Ropp JS, Trewhella J et al (1989) Conformational analysis of PKI(5-22)amide, the active inhibitory fragment of the inhibitor protein of the cyclic AMP-dependent protein kinase. Biochem J 264:371-380
61. Glass DB, Feller MJ, Levin LR et al (1992) Structural basis for the low affinities of yeast cAMP-dependent and mammalian cGMPdependent protein kinases for protein kinase inhibitor peptides. Biochemistry 31: 1728-1734
62. Hidaka H, Inagaki M, Kawamoto S et al (1984) Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23:5036-5041
63. Chijiwa T, Mishima A, Hagiwara M et al (1990) Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(pb romo cinnamylamino) ethyl]-5- isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 265: 5267-5272
64. Murray AJ (2008) Pharmacological PKA inhibition: all may not be what it seems. Sci Signal 1:re4. doi: 10.1126/scisignal.122re4
65. Rothermel JD, Stec WJ, Baraniak J et al (1983) Inhibition of glycogenolysis in isolated rat hepatocytes by the Rp diastereomer of adenosine cyclic 3′,5′-phosphorothioate. J Biol Chem 258:12125-12128
66. Rothermel JD, Jastorff B, Botelho LH (1984) Inhibition of glucagon-induced glycogenolysis in isolated rat hepatocytes by the Rp diastereomer of adenosine cyclic 3′,5′-phosphorothioate. J Biol Chem 259:8151-8155
67. Gjertsen BT, Mellgren G, Otten A et al (1995) Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin- 1 beta action. J Biol Chem 270: 20599-20607
68. Kinderman FS, Kim C, von Daake S et al (2006) A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell 24:397-408
69. Banky P, Newlon MG, Roy M et al (2000) Isoform-specific differences between the type Ialpha and IIalpha cyclic AMP-dependent protein kinase anchoring domains revealed by solution NMR. J Biol Chem 275:35146-35152. doi: 10.1074/jbc.M003961200