Adenosine monophosphate is elevated in the bronchoalveolar lavage fluid of mice with acute respiratory toxicity induced by nanoparticles with high surface hydrophobicity

Nanotoxicology

Volumn 9, Issue 1, 2015, Pages 106-115

  Dailey, Lea Ann ^a,b   Hernández Prieto, Raquel ^a,c   Casas Ferreira, Ana Maria ^c   Jones, Marie Christine ^d   Riffo Vasquez, Yanira ^a   Rodríguez Gonzalo, Encarnación ^c   Spina, Domenico ^a   Jones, Stuart A ^a   Smith, Norman W ^a   Forbes, Ben ^a   Page, Clive ^a   Legido Quigley, Cristina ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b Imperial College London   (United Kingdom)

^c UNIVERSITY OF SALAMANCA   (Spain)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

AMP; Broncho alveolar lavage; Hydrophobicity; Inflammation; Lung; Metabolomics; Nanoparticles

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE PHOSPHATE; CXCL1 CHEMOKINE; INTERLEUKIN 1BETA; NANOCAPSULE; NANOMATERIAL; NANOPARTICLE; POLYSTYRENE; POLYVINYL ACETATE; TUMOR NECROSIS FACTOR ALPHA; POLYSTYRENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HYDROPHOBICITY; INFLAMMATION; LUNG LAVAGE; LUNG TOXICITY; MALE; METABOLOMICS; MOUSE; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; SURFACE PROPERTY; TIME OF FLIGHT MASS SPECTROMETRY; TISSUE INJURY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BAGG ALBINO MOUSE; BRONCHOALVEOLAR LAVAGE FLUID; CHEMICAL PHENOMENA; CHEMICALLY INDUCED; CHEMISTRY; METABOLISM; PNEUMONIA;

MUS;

ADENOSINE MONOPHOSPHATE; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MALE; MICE; MICE, INBRED BALB C; NANOPARTICLES; PNEUMONIA; POLYSTYRENES; SURFACE PROPERTIES;

EID: 84925302826     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2014.894150     Document Type: Article

References (47)

1. Aitken R, Borm P, Donaldson K, Ichihara G, Loft S, Marano F, et al. 2009. Nanoparticles-one word: a multiplicity of different hazards. Nanotoxicol 3:263-4.
2. Barletta KE, Ley K, Mehrad B. 2012. Regulation of neutrophil function by adenosine. Arterioscler Thromb Vasc Biol 32:856-64.
3. Beyerle A, Braun A, Banjeree A, Ercal N, Eickelberg O, Kissel T, Stoeger T. 2011. Inflammatory responses to pulmonary application of PEI-based siRNA nanocarriers in mice. Biomaterials 32:8694-701.
4. Bivas-Benita M, Zwier R, Junginger HE, Borchard G. 2005. Non-invasive pulmonary aerosol delivery in mice by the endotracheal route. Eur J Pharm Biopharm 61:214-18.
5. Blackburn MR, Vance CO, Morschl E, Wilson CN. 2009. Adenosine receptors and inflammation. In Wilson CN & Mustafa SJ, eds. Adenosine Receptors in Health and Disease. Heidelberg: Springer-Verlag, 215-69.
6. Brown DM, Wilson MR, MacNee W, Stone V, Donaldson K. 2001. Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol Appl Pharmacol 175:191-9.
7. Bu Q, Yan G, Deng P, Peng F, Lin H, Xu Y, et al. 2010. NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration. Nanotechnology 21: 125105.
8. Burch LH, Picher M. 2006. E-NTPDases in human airways: regulation and relevance for chronic lung diseases. Purinergic Signal 2:399-408.
9. Button BM, Button B. 2013. Structure and function of the mucus clearance system of the lung. Cold Spring Harb Perspect Med 3:a009720.
10. Carstensen H, Müller BW, Müller RH. 1991. Adsorption of ethoxylated surfactants on nanoparticles: 1. Characterization by hydrophobic interaction chromatography. Int J Pharm 67:29-37.
11. Chana J, Forbes B, Jones SA. 2008. The synthesis of high molecular weight partially hydrolysed poly(vinyl alcohol) grades suitable for nanoparticle fabrication. J Nanosci Nanotech 8:5739-47.
12. Cho WS, Duffin R, Thielbeer F, Bradley M, Megson IL, MacNee W, et al. 2012. Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal/metal oxide nanoparticles. Toxicol Sci 126:469-77.
13. Dailey LA. 2009. Considerations for the design of toxicity studies of inhaled nanomedicines. In: Sahu SC & Casciano DA, eds. Nanotoxicity. From In Vivo and In Vitro Models to Health Risks. Chichester: John Wiley & Sons Ltd, 41-60.
14. Dailey LA, Jekel N, Fink L, Gessler T, Schmehl T, Wittmar M, et al. 2006. Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung. Toxicol Appl Pharmacol 215:100-8.
15. Donaldson K, Borm PJA, Oberdörster G, Pinkerton KE, Stone V, Tran CL. 2008. Concordance between in vitro and in vivo dosimetry in the proinflammatory effects of low-toxicity, low-solubility particles: the key role of the proximal alveolar region. Inhal Toxicol 20:53-62.
16. Donaldson K, Stone V, Gilmour PS, Brown DM, MacNee W. 2000. Ultrafine particles: mechanisms of lung injury. Philosoph Trans Royal Soc London Ser a-Math Phys Eng Sci 358:2741-8.
17. Duffin R, Tran L, Brown D, Stone V, Donaldson K. 2007. Proinflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity. Inhal Toxicol 19:849-56.
18. Esther CR, Alexis NE, Clas ML, Lazarowski ER, Donaldson SH, Rlbeiro CMP, et al. 2008a. Extracellular purines are biomarkers of neutrophilic airway inflammation. Eur Resp J 31:949-56.
19. Esther CR, Boysen G, Olsen BM, Collins LB, Ghio AJ, Swenberg JW, Boucher RC. 2009. Mass spectrometric analysis of biomarkers and dilution markers in exhaled breath condensate reveals elevated purines in asthma and cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 296: L987-93.
20. Esther CR, Jasin HM, Collins LB, Swenberg JA, Boysen G. 2008b. A mass spectrometric method to simultaneously measure a biomarker and dilution marker in exhaled breath condensate. Rapid Commun Mass Spectrom 22:701-5.
21. Fadeel B, Pietrouitisi A, Shvendova AA. 2012. Adverse effects of engineered nanomaterials: exposure, toxicology, and impact on human health. London. Waltham, MA: Elsevier/Academic Press.
22. Garcia-Perez I, Earll ME, Angulo S, Barbas C, Legido-Quigely C. 2010. Chemometric analysis of urine fingerprints acquired by liquid chroma-tography-mass spectrometry and capillary electrophoresis: Application to the schistosomiasis mouse model. Electrophoresis 31:2349-55.
23. Harush-Frenkel O, Bivas-Benita M, Nassar T, Springer C, Sherman Y, Avital A, et al. 2010. A safety and tolerability study of differently-charged nanoparticles for local pulmonary drug delivery. Toxicol Appl Pharmacol 246:83-90.
24. Heurtault B, Saulnier P, Pech B, Benoit JP, Proust JE. 2003. Interfacial stability of lipid nanocapsules. Coll Surf B-Biointerfaces 30:225-35.
25. Hu JZ, Rommereim DNR, Minard KR, Woodstock A, Harrer BJ, Wind RA, et al. 2008. Metabolomics in lung inflammation: a high-resolution 1H NMR study of mice exposed to silica dust. Toxicol Mech Methods 18:385-98.
26. Jackson EK, Ren J, Mi Z. 2009. Extracellular 2, 3-cAMP is a source of adenosine. J Biol Chem 284:33097-106.
27. Jacob F, Novo CP, Bachert C, Van Crombruggen K. 2013. Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses. Purinergic Signal 9:285-306.
28. Lei RH, Wu CQ, Yang BH, Ma HZ, Shi C, Wang QJ, et al. 2008. Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: a rapid in vivo screening method for nanotoxicity. Toxicol Appl Pharmacol 232: 292-301.
29. Liu YJ, Ibricevic A, Cohen JA, Cohen JL, Gunsten SP, Frechet JMJ, et al. 2009. Impact of hydrogel nanoparticle size and functionalization on in vivo behavior for lung imaging and therapeutics. Mol Pharm 6: 1891-902.
30. Lorusso D, Di Stefano A, Carone V, Fagotti A, Pisconti S, Scambia G. 2007. Pegylated liposomal doxorubicin-related palmar-plantar erythro-dysesthesia ('hand-foot' syndrome). Ann Oncol 18:1159-64.
31. Lu XY, Tian Y, Zhao QQ, Jin TT, Xiao S, Fan XH. 2011. Integrated metabonomics analysis of the size-response relationship of silica nanoparticles-induced toxicity in mice. Nanotechnology 22: 055101 (1-16).
32. Maynard AD, Warheit DB, Philbert MA. 2011. The new toxicology of sophisticated materials: nanotoxicology and beyond. Toxicol Sci 120: S109-29.
33. Moghimi SM, Szebeni J. 2003. Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties. Prog Lipid Res 42:463-78.
34. Nalwa HS. 2009. Soft Nanomaterials. Stevenson Ranch, CA: American Scientific Publishers.
35. Nassimi M, Schleh C, Lauenstein HD, Hussein R, Lübbers K, Pohlmann G, et al. 2009. Low cytotoxicity of solid lipid nanoparticles in in vitro and ex vivo lung models. Inhal Toxicol 21:104-9.
36. Patel K, Davis SD, Johnson R, Esther CR. 2013. Exhaled breath condensate purines correlate with lung function in infants and preschoolers. Ped Pulmonol 48:182-7.
37. Picher M, Burch LH, Boucher RC. 2004. Metabolism of P2 receptor agonists in human airways-implications for mucociliary clearance and cystic fibrosis. J Biol Chem 279:20234-41.
38. Picher M, Burch LH, Hirsh AJ, Spychala J, Boucher RC. 2003. Ecto 5-nucleotidase and nonspecific alkaline phosphatase-two amp-hydrolyzing ectoenzymes with distinct roles in human airways. J Biol Chem 278:13468-79.
39. Reutershan J, Vollmer I, Stark S, Wagner R, Ngamsri KC, Eltzschig HK. 2009. Adenosine and inflammation: CD39 and CD73 are critical mediators of LPS-induced PMN trafficking into the lungs. FASEB J 23:473-82.
40. Robson SC, Sevigny J, Zimmermann H. 2006. The E-NTPDase family of ectonucleotidases: structure function relationships and pathophysio-logical significance. Purinergic Signal 2:409-30.
41. Ruge CA, Schaefer UF, Herrmann J, Kirch J, Canadas O, Echaide M, et al. 2012. The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles. PLoS One 7:e40775.
42. Schmidt EP, Tuder RM. 2010. Role of apoptosis in amplifying inflammatory responses in lung disease. J Cell Death 3:41-53.
43. Singh R, Lillard JW. 2009. Nanoparticle-based targeted drug delivery. Exp Mol Pathol 86:215-23.
44. Vaine CA, Patel MK, Zhu JT, Lee E, Finberg RW, Hayward RC, Kurt-Jones EA. 2013. Tuning innate immune activation by surface texturing of polymer microparticles: the role of shape in inflamma-some activation. J Immunol 190:3525-32.
45. Whiley L, Godzien J, Ruperez FJ, Legido-Quigley C, Barbas C. 2012. In-vial dual extraction for direct LC-MS analysis of plasma for comprehensive and highly reproducible metabolic fingerprinting. Anal Chem 84:5992-9.
46. Wolak JE, Esther CR, O'Connell TM. 2009. Metabolomic analysis of bronchoalveolar lavage fluid from cystic fibrosis patients. Biomarkers 14:55-60.
47. Xiayan L, Legido-Quigley C. 2008. Advances in separation science applied to metabonomics. Electrophoresis 29:3724-36.