Symptoms and characteristics of individuals with profound hyponatremia: A prospective multicenter observational study

Journal of the American Geriatrics Society

Volumn 63, Issue 3, 2015, Pages 470-475

  Nigro, Nicole ^a   Winzeler, Bettina ^a   Suter Widmer, Isabelle ^a   Schuetz, Philipp ^a,b   Arici, Birsen ^a   Bally, Martina ^a,b   Blum, Claudine ^a   Bingisser, Roland ^a   Bock, Andreas ^a,b   Huber, Andreas ^a,b   Müller, Beat ^a,b   Nickel, Christian H ^a   Christ Crain, Mirjam ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b CANTONAL HOSPITAL AARAU   (Switzerland)

Author keywords

clinical characteristics and symptoms; profound hyponatremia

Indexed keywords

ANGIOTENSIN RECEPTOR; ANTIHYPERTENSIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LOOP DIURETIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; POTASSIUM SPARING DIURETIC AGENT; SODIUM; THIAZIDE DIURETIC AGENT;

AGED; ARTICLE; BODY TEMPERATURE; BRAIN CELL; BRAIN CELL ADAPTATION; BRAIN FUNCTION; CELL FUNCTION; CENTRAL NERVOUS SYSTEM DISEASE; CHRONIC KIDNEY FAILURE; CLINICAL FEATURE; CLINICAL TRIAL; COMORBIDITY; CONGESTIVE HEART FAILURE; CONSENSUS; DIASTOLIC BLOOD PRESSURE; DIFFERENTIAL DIAGNOSIS; FATIGUE; FEMALE; GAIT DISORDER; HEART FAILURE; HOSPITALIZATION; HUMAN; HYPERTENSION; HYPONATREMIA; LUNG DISEASE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; MULTICENTER STUDY; NAUSEA; SEIZURE; SEPTIC SHOCK; SODIUM BLOOD LEVEL; SYMPTOM ASSESSMENT; SYSTOLIC BLOOD PRESSURE; VOMITING; WEAKNESS; MIDDLE AGED; PROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX; VERY ELDERLY;

AGED; AGED, 80 AND OVER; FEMALE; HOSPITALIZATION; HUMANS; HYPONATREMIA; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 84925297208     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/jgs.13325     Document Type: Article

References (30)

1. Upadhyay A, Jaber BL, Madias NE,. Epidemiology of hyponatremia. Semin Nephrol 2009; 29: 227-238.
2. Rabinstein AA, Wijdicks EF,. Hyponatremia in critically ill neurological patients. Neurologist 2003; 9: 290-300.
3. Spasovski G, Vanholder R, Allolio B, et al. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Nephrol Dial Transplant 2014; 29 (Suppl 2): i1-i39.
4. Verbalis JG, Goldsmith SR, Greenberg A, et al. Diagnosis, evaluation, and treatment of hyponatremia: Expert panel recommendations. Am J Med 2013; 126: S1-S42.
5. Adrogue HJ, Madias NE,. Hyponatremia. N Engl J Med 2000; 342: 1581-1589.
6. Arieff AI, Llach F, Massry SG,. Neurological manifestations and morbidity of hyponatremia: Correlation with brain water and electrolytes. Medicine (Baltimore) 1976; 55: 121-129.
7. Kumar S, Berl T,. Sodium. Lancet 1998; 352: 220-228.
8. Bourque CW,. Central mechanisms of osmosensation and systemic osmoregulation. Nat Rev Neurosci 2008; 9: 519-531.
9. Renneboog B, Musch W, Vandemergel X, et al. Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med 2006; 119: 71.e1-e8.
10. Spasovski G, Vanholder R, Allolio B, et al. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Eur J Endocrinol 2014; 170: G1-G47.
11. Waikar SS, Mount DB, Curhan GC,. Mortality after hospitalization with mild, moderate, and severe hyponatremia. Am J Med 2009; 122: 857-865.
12. Liamis G, Rodenburg EM, Hofman A, et al. Electrolyte disorders in community subjects: Prevalence and risk factors. Am J Med 2013; 126: 256-263.
13. Wald R, Jaber BL, Price LL, et al. Impact of hospital-associated hyponatremia on selected outcomes. Arch Intern Med 2010; 170: 294-302.
14. Hoorn EJ, Zietse R,. Hyponatremia and mortality: Moving beyond associations. Am J Kidney Dis 2013; 62: 139-149.
15. Liamis G, Tsimihodimos V, Doumas M, et al. Clinical and laboratory characteristics of hypernatraemia in an internal medicine clinic. Nephrol Dial Transplant 2008; 23: 136-143.
16. Arampatzis S, Frauchiger B, Fiedler GM, et al. Characteristics, symptoms, and outcome of severe dysnatremias present on hospital admission. Am J Med 2012; 125: 1125.e1-1125.e7.
17. Gill G, Huda B, Boyd A, et al. Characteristics and mortality of severe hyponatraemia-a hospital-based study. Clin Endocrinol (Oxf) 2006; 65: 246-249.
18. Tolouian R, Alhamad T, Farazmand M, et al. The correlation of hip fracture and hyponatremia in the elderly. J Nephrol 2012; 25: 789-793.
19. Kinsella S, Moran S, Sullivan MO, et al. Hyponatremia independent of osteoporosis is associated with fracture occurrence. Clin J Am Soc Nephrol 2010; 5: 275-280.
20. Adrogue HJ, Madias NE,. Aiding fluid prescription for the dysnatremias. Intensive Care Med 1997; 23: 309-316.
21. Ellis SJ,. Severe hyponatraemia: Complications and treatment. QJM 1995; 88: 905-909.
22. Mohmand HK, Issa D, Ahmad Z, et al. Hypertonic saline for hyponatremia: Risk of inadvertent overcorrection. Clin J Am Soc Nephrol 2007; 2: 1110-1117.
23. Bennani SL, Abouqal R, Zeggwagh AA, et al. [Incidence, causes and prognostic factors of hyponatremia in intensive care]. Rev Med Interne 2003; 24: 224-229.
24. Arieff AI,. Hyponatremia, convulsions, respiratory arrest, and permanent brain damage after elective surgery in healthy women. N Engl J Med 1986; 314: 1529-1535.
25. Ayus JC, Wheeler JM, Arieff AI,. Postoperative hyponatremic encephalopathy in menstruant women. Ann Intern Med 1992; 117: 891-897.
26. Hsu YJ, Chiu JS, Lu KC, et al. Biochemical and etiological characteristics of acute hyponatremia in the emergency department. J Emerg Med 2005; 29: 369-374.
27. Balling L, Schou M, Videbaek L, et al. Prevalence and prognostic significance of hyponatraemia in outpatients with chronic heart failure. Eur J Heart Fail 2011; 13: 968-973.
28. Vaa BE, Asrani SK, Dunn W, et al. Influence of serum sodium on MELD-based survival prediction in alcoholic hepatitis. Mayo Clin Proc 2011; 86: 37-42.
29. Rodenburg EM, Hoorn EJ, Ruiter R, et al. Thiazide-associated hyponatremia: A population-based study. Am J Kidney Dis 2013; 62: 67-72.
30. Liamis G, Milionis H, Elisaf M,. A review of drug-induced hyponatremia. Am J Kidney Dis 2008; 52: 144-153.