The reversible P2Y12 inhibitor ticagrelor inhibits metastasis and improves survival in mouse models of cancer

International Journal of Cancer

Volumn 136, Issue 1, 2015, Pages 234-240

  Gebremeskel, Simon ^a   Levatte, Terry ^a   Liwski, Robert S ^a   Johnston, Brent ^a   Bezuhly, Michael ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

ADP receptor; breast cancer; endothelium; melanoma; metastasis; P2Y12; platelet; ticagrelor

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CLOPIDOGREL; PURINERGIC P2Y12 RECEPTOR; TICAGRELOR; ADENOSINE; ANTINEOPLASTIC AGENT; P2RY12 PROTEIN, MOUSE; PURINERGIC P2Y RECEPTOR ANTAGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B16 F10 CELL LINE; BONE MARROW METASTASIS; BREAST CANCER; CANCER SURVIVAL; CELL ADHESION; CELL INTERACTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; FEASIBILITY STUDY; FEMALE; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; LUNG METASTASIS; MELANOMA; MELANOMA CELL LINE; METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SPLENIC METASTASIS; THROMBOCYTE ACTIVATION; TUMOR CELL; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; BONE NEOPLASMS; C57BL MOUSE; CANCER TRANSPLANTATION; DRUG SCREENING; GENETICS; LIVER NEOPLASMS; LUNG NEOPLASMS; MAMMARY NEOPLASMS, EXPERIMENTAL; MELANOMA, EXPERIMENTAL; METABOLISM; PATHOLOGY; SECONDARY;

ADENOSINE; ANIMALS; ANTINEOPLASTIC AGENTS; BONE NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; GENE EXPRESSION; LIVER NEOPLASMS; LUNG NEOPLASMS; MAMMARY NEOPLASMS, EXPERIMENTAL; MELANOMA, EXPERIMENTAL; MICE, INBRED BALB C; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2Y12;

EID: 84925286513     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28947     Document Type: Article

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