Associations between medication use and homocysteine levels in an older population, and potential mediation by vitamin B12 and folate: Data from the B-PROOF study

Drugs and Aging

Volumn 31, Issue 8, 2014, Pages 611-621

  Ham, Annelies C ^a   Enneman, Anke W ^a   Van Dijk, Suzanne C ^a   Oliai Araghi, Sadaf ^a   Swart, Karin M A ^b   Sohl, Evelien ^b   Van Wijngaarden, Janneke P ^c   Van Der Zwaluw, Nikita L ^c   Brouwer Brolsma, Elske M ^c   Dhonukshe Rutten, Rosalie A M ^c   Van Schoor, Natasja M ^b   Van Der Cammen, Tischa J M ^a   Zillikens, M Carola ^a   De Jonge, Robert ^a   Lips, Paul ^b   De Groot, Lisette C P G M ^c   Van Meurs, Joyce B J ^a   Uitterlinden, André G ^a   Witkamp, Renger F ^c   Stricker, Bruno H C ^a   Van Der Velde, Nathalie ^a,d   more..

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c WAGENINGEN UNIVERSITY   (Netherlands)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BIGUANIDE DERIVATIVE; CARBAMAZEPINE; COLESTYRAMINE; CYANOCOBALAMIN; DIHYDROPYRIDINE DERIVATIVE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; FIBRIC ACID DERIVATIVE; FOLIC ACID; HISTAMINE H2 RECEPTOR ANTAGONIST; HOMOCYSTEINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; LEVODOPA; METFORMIN; METHOTREXATE; PHENYTOIN; PLACEBO; PROTON PUMP INHIBITOR; RALOXIFENE; ROSIGLITAZONE; SALAZOSULFAPYRIDINE; SULFONAMIDE; SULFONYLUREA DERIVATIVE; TAMOXIFEN; THIAZIDE DIURETIC AGENT; UNINDEXED DRUG; VALPROIC ACID;

AGED; AMINO ACID BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FRAGILITY FRACTURE; GERIATRIC PATIENT; GROUPS BY AGE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SELF REPORT; VITAMIN SUPPLEMENTATION; BLOOD; CYANOCOBALAMIN DEFICIENCY; ELDERLY CARE; HEALTH SURVEY; NETHERLANDS; OSTEOPOROSIS;

AGED; DIURETICS; FEMALE; FOLIC ACID; HEALTH SERVICES FOR THE AGED; HOMOCYSTEINE; HUMANS; MALE; METFORMIN; NETHERLANDS; OSTEOPOROSIS; POPULATION SURVEILLANCE; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 84925285966     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.1007/s40266-014-0192-2     Document Type: Article

References (62)

1. de Bree A, van der Put NM, Mennen LI, et al. Prevalences of hyperhomocysteinemia, unfavorable cholesterol profile and hypertension in European populations. Eur J Clin Nutr. 2005;59(4):480-8. (Pubitemid 40528660)
2. Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ. 2002;325(7374):1202.
3. Boushey CJ, Beresford SA, Omenn GS, et al. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA. 1995;274(13):1049-57.
4. McLean RR, Jacques PF, Selhub J, et al. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med. 2004;350(20):2042-9. (Pubitemid 38596555)
5. van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM, et al. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med. 2004;350(20):2033-41.
6. 12, folate, homocysteine, and bone health in adults and elderly people: a systematic review with meta-analyses. J Nutr Metab. 2013;2013:486186.
7. Ford AH, Flicker L, Hankey GJ, et al. Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and cognitive impairment: the Health in Men study. Mol Psychiatry. 2012;17(5):559-66.
8. 12, folate and cognitive functions: a systematic and critical review of the literature. Int J Clin Pract. 2009;63(7):1061-7.
9. 12 in health and disease. Nutr Rev. 2004;62 (6 Pt 2):S3-12; discussion S3.
10. Marti-Carvajal AJ, Sola I, Lathyris D, et al. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2013;1:CD006612.
11. 12 and folic acid on fracture incidence. BMC Geriatr. 2011;11:80.
12. Walker JG, Batterham PJ, Mackinnon AJ, et al. Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with depressive symptoms: the Beyond Ageing Project: a randomized controlled trial. Am J Clin Nutr. 2012;95(1):194-203.
13. Ford AH, Almeida OP. Effect of homocysteine lowering treatment on cognitive function: a systematic review and meta-analysis of randomized controlled trials. J Alzheimers Dis. 2012;29(1):133-49.
14. Holmes MV, Newcombe P, Hubacek JA, et al. Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. Lancet. 2011;378(9791):584-94.
15. Pham CB, Dickman RL. Minimizing adverse drug events in older patients. Am Fam Physician. 2007;76(12):1837-44.
16. Hayes BD, Klein-Schwartz W, Barrueto Jr F. Polypharmacy and the geriatric patient. Clin Geriatr Med. 2007;23(2):371-90. doi:10.1016/j.cger.2007.01.002. (Pubitemid 46621142)
17. Kongkaew C, Noyce PR, Ashcroft DM. Hospital admissions associated with adverse drug reactions: a systematic review of prospective observational studies. Ann Pharmacother. 2008;42(7):1017-25.
18. Bushardt RL, Massey EB, Simpson TW, et al. Polypharmacy: misleading, but manageable. Clin Interv Aging. 2008;3(2):383-9. (Pubitemid 352037877)
19. Desouza C, Keebler M, McNamara DB, et al. Drugs affecting homocysteine metabolism: impact on cardiovascular risk. Drugs. 2002;62(4):605-16. (Pubitemid 34264028)
20. Dierkes J, Luley C, Westphal S. Effect of lipid-lowering and antihypertensive drugs on plasma homocysteine levels. Vasc Health Risk Manag. 2007;3(1):99-108. (Pubitemid 46863141)
21. 12 (Cbl) deficiency. Diabetes Res Clin Pract. 2012;97(3):359-67.
22. ATC and DDD Index. WHO Collaborating Centre for Drug Statistics Methodology, Oslo, Norway. http://www.whocc.no/atc-ddd-index/.
23. 12 deficiency: a multicentre study. Ann Clin Biochem. 2012;49(Pt 2):184-9.
24. Whitworth JA. World Health Organization ISoHWG. 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens. 2003;21(11):1983-92. (Pubitemid 38296854)
25. Poduri A, Kaur J, Thakur JS, et al. Effect of ACE inhibitors and beta-blockers on homocysteine levels in essential hypertension. J Hum Hypertens. 2008;22(4):289-94. (Pubitemid 351419497)
26. Roush GC, Kaur R, Ernst ME. Diuretics: a review and update. J Cardiovasc Pharmacol Ther. 2013;. doi:10.1177/1074248413497257.
27. Fan FF, Huo Y, Wang X, et al. Effect of enalapril on plasma homocysteine levels in patients with essential hypertension. J Zhejiang Univ Sci B. 2010;11(8):583-91.
28. Westphal S, Rading A, Luley C, et al. Antihypertensive treatment and homocysteine concentrations. Metabolism. 2003;52(3):261-3. doi:10.1053/meta. 2003.50060. (Pubitemid 36401668)
29. Wile DJ, Toth C. Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy. Diabet Care. 2010;33(1):156-61.
30. de Jager J, Kooy A, Lehert P, et al. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ. 2010;340: C2181. doi:10.1136/Bmj.C2181.
31. 12 in patients with type 2 diabetes mellitus. J Diabet Complic. 2007;21(2):118-23.
32. 12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial. J Intern Med. 2003;254(5):455-63.
33. Fonseca VA, Fink LM, Kern PA. Insulin sensitivity and plasma homocysteine concentrations in non-diabetic obese and normal weight subjects. Atherosclerosis. 2003;167(1):105-9. doi:10.1016/S0021-9150(02)00386-6. (Pubitemid 36255641)
34. Giltay EJ, Hoogeveen EK, Elbers JMH, et al. Insulin resistance is associated with elevated plasma total homocysteine levels in healthy, non-obese subjects. Atherosclerosis. 1998;139(1):197-8. (Pubitemid 28341883)
35. 12 status in older adults? J Am Med Dir Assoc. 2008;9(3):162-7.
36. Valuck RJ, Ruscin JM. A case-control study on adverse effects: H2 blocker or proton pump inhibitor use and risk of vitamin B12 deficiency in older adults. J Clin Epidemiol. 2004;57(4):422-8. (Pubitemid 38609284)
37. Mitchell SL, Rockwood K. The association between antiulcer medication and initiation of cobalamin replacement in older persons. J Clin Epidemiol. 2001;54(5):531-4. (Pubitemid 32409337)
38. Marcuard SP, Albernaz L, Khazanie PG. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12). Ann Intern Med. 1994;120(3):211-5.
39. van der Loo B, Spring S, Koppensteiner R. High-dose atorvastatin treatment in patients with peripheral arterial disease: effects on platelet aggregation, blood rheology and plasma homocysteine. Clin Hemorheol Microcirc. 2011;47(4):241-51.
40. Jiang S, Chen Q, Venners SA, et al. Effect of simvastatin on plasma homocysteine levels and its modification by MTHFR C677T polymorphism in Chinese patients with primary hyperlipidemia. Cardiovasc Ther. 2013;31(4):e27-33.
41. 12 in epileptic patients under carbamazepine and sodium valproate treatment: a systematic review and meta-analysis. Iran Red Crescent Med J. 2013;15(3):249-53.
42. Paknahad Z, Chitsaz A, Zadeh AH, et al. Effects of common anti-epileptic drugs on the serum levels of homocysteine and folic acid. Int J Prev Med. 2012;3(Suppl 1):S186-90.
43. Sener U, Zorlu Y, Karaguzel O, et al. Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, vitamin B12, folic acid and vitamin B6. Seizure. 2006;15(2):79-85. (Pubitemid 43192416)
44. Coppola G, Ingrosso D, Operto FF, et al. Role of folic acid depletion on homocysteine serum level in children and adolescents with epilepsy and different MTHFR C677T genotypes. Seizure. 2012;21(5):340-3. doi:10.1016/j.seizure.2012. 02.011.
45. Belcastro V, Striano P. Antiepileptic drugs, hyperhomocysteinemia and B-vitamins supplementation in patients with epilepsy. Epilepsy Res. 2012;102(1-2):1-7.
46. Hu XW, Qin SM, Li D, et al. Elevated homocysteine levels in levodopa-treated idiopathic Parkinson's disease: a meta-analysis. Acta Neurol Scand. 2013;128(2):73-82. doi:10.1111/ane.12106.
47. Klungel OH, de Boer A, Paes AH, et al. Agreement between self-reported antihypertensive drug use and pharmacy records in a population-based study in The Netherlands. Pharm World Sci. 1999;21(5):217-20. (Pubitemid 29485013)
48. Rauma PH, Koivumaa-Honkanen H, Kroger H, et al. The relationship between self-reported and registry-based data on use of psychoactive medications in postmenopausal women. BMC Psychiatry. 2013;13:180.
49. Allin S, Bayoumi AM, Law MR, et al. Comparability of self-reported medication use and pharmacy claims data. Health Rep. 2013;24(1):3-9.
50. Boudreau DM, Daling JR, Malone KE, et al. A validation study of patient interview data and pharmacy records for antihypertensive, statin, and antidepressant medication use among older women. Am J Epidemiol. 2004;159(3):308-17. doi:10.1093/aje/kwh038. (Pubitemid 38141661)
51. Nygard O, Vollset SE, Refsum H, et al. Total plasma homocysteine and cardiovascular risk profile: the Hordaland Homocysteine Study. JAMA. 1995;274(19):1526-33.
52. Ventura P, Panini R, Verlato C, et al. Hyperhomocysteinemia and related factors in 600 hospitalized elderly subjects. Metabolism. 2001;50(12):1466-71. doi:10.1053/meta.2001.28079. (Pubitemid 34007419)
53. Pongchaidecha M, Srikusalanukul V, Chattananon A, et al. Effect of metformin on plasma homocysteine, vitamin B12 and folic acid: a cross-sectional study in patients with type 2 diabetes mellitus. J Med Assoc Thai. 2004;87(7):780-7. (Pubitemid 39166079)
54. 12 supplements: the National Health and Nutrition Examination Survey, 1999-2006. Diabet Care. 2012;35(2):327-33.
55. Derosa G, Mugellini A, Ciccarelli L, et al. Comparison between repaglinide and glimepiride in patients with type 2 diabetes mellitus: a one-year, randomized, double-blind assessment of metabolic parameters and cardiovascular risk factors. Clin Ther. 2003;25(2):472-84. (Pubitemid 36286914)
56. Derosa G, Franzetti I, Gadaleta G, et al. Metabolic variations with oral antidiabetic drugs in patients with type 2 diabetes: comparison between glimepiride and metformin. Diabet Nutr Metab. 2004;17(3):143-50. (Pubitemid 39117274)
57. Wang Y, Zhang L, Moslehi R, et al. Long-term garlic or micronutrient supplementation, but not anti-Helicobacter pylori therapy, increases serum folate or glutathione without affecting serum vitamin B-12 or homocysteine in a rural Chinese population. J Nutr. 2009;139(1):106-12.
58. Shea B, Swinden MV, Tanjong Ghogomu E, et al. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. Cochrane Database Syst Rev. 2013;5:951.
59. Zoccolella S, dell' Aquila C, Abruzzese G, et al. Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease dementia. Mov Disord. 2009;24(7):1028-33.
60. Lamberti P, Zoccolella S, Iliceto G, et al. Effects of levodopa and COMT inhibitors on plasma homocysteine in Parkinson's disease patients. Mov Disord. 2005;20(1):69-72. (Pubitemid 40277507)
61. Clarke R, Harrison G, Richards S, et al. Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia. J Intern Med. 2003;254(1):67-75. (Pubitemid 36819131)
62. 12 deficiency (results of the BACH study). Am J Cardiol. 2004;94(7):975-7.