Polypharmacy and the Geriatric Patient

Clinics in Geriatric Medicine

Volumn 23, Issue 2, 2007, Pages 371-390

  Hayes, Bryan D ^a   Klein Schwartz, Wendy ^a   Barrueto Jr , Fermin ^b,c  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMIODARONE; AMLODIPINE; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE; CARBAMAZEPINE; CIMETIDINE; CLOPIDOGREL; CODEINE; COTRIMOXAZOLE; DEXTROPROPOXYPHENE; DIPYRIDAMOLE; ENOXAPARIN; FLUCONAZOLE; FLUINDOSTATIN; HYDROCODONE; METOPROLOL; METRONIDAZOLE; MEVINOLIN; PAROXETINE; PHENYTOIN; PROPAFENONE; PROPRANOLOL; QUINIDINE; RIFAMPICIN; SERTRALINE; TICLOPIDINE; UNINDEXED DRUG; WARFARIN; ZAFIRLUKAST;

DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG RESPONSE; DRUG USE; EMERGENCY WARD; GERIATRIC CARE; GLOMERULUS FILTRATION RATE; HEALTH SURVEY; HUMAN; LONG QT SYNDROME; POLYPHARMACY; REVIEW; RISK FACTOR;

AGED; ANTICOAGULANTS; CHOLINERGIC ANTAGONISTS; DRUG INTERACTIONS; DRUG MONITORING; HUMANS; HYPNOTICS AND SEDATIVES; LONG QT SYNDROME; POLYPHARMACY; WARFARIN;

EID: 34247202046     PISSN: 07490690     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cger.2007.01.002     Document Type: Review

References (66)

1. Chutka D.S., Evans J.M., Fleming K.C., et al. Drug prescribing for elderly patients. Mayo Clin Proc 70 7 (1995) 685-693
2. Chutka D.S., Takahashi P.Y., and Hoel R.W. Inappropriate medications for elderly patients. Mayo Clin Proc 79 (2004) 122-139
3. Kaufman D.W., Kelly J.P., Rosenberg L., et al. Recent patterns of medication use in the ambulatory adult population of the United States. JAMA 287 (2002) 337-344
4. Cannon K.T., Choi M.M., and Zuniga M.A. Potentially inappropriate medication use in elderly patients receiving home health care: a retrospective data analysis. Am J Geriatr Pharmacother 4 2 (2006) 134-143
5. Jyrkka J., Vartiainen L., Hartikainen S., et al. Increasing use of medicines in elderly persons: a five-year follow-up of the Kuopio 75+ Study. Eur J Clin Pharmacol 62 2 (2006) 151-158
6. Beers M.H. Explicit criteria for determining potentially inappropriate medication use by the elderly. An update. Arch Intern Med 157 (1997) 1531-1536
7. Fick D.M., Cooper J.W., Wade W.E., et al. Updating the Beers criteria for potentially inappropriate medication use in older adults. Arch Intern Med 163 (2003) 2716-2724
8. Hanlon J.T., Schmader K.E., Koronkowski M.J., et al. Adverse drug events in high risk older outpatients. J Am Geriatr Soc 45 8 (1997) 945-948
9. Beard K. Adverse reactions as a cause of hospital admissions in the aged. Drugs Aging 2 (1992) 356-367
10. Hohl C.M., Dankoff J., Colacone A., et al. Polypharmacy, adverse drug-related events, and potential adverse drug interaction in elderly patients presenting to an emergency department. Ann Emerg Med 38 6 (2001) 666-671
11. Gurwitz J.H., Field T.S., Harrold L.R., et al. Incidence and preventability of adverse drug events among older persons in the ambulatory setting. JAMA 289 (2003) 1107-1116
12. Hajjar E.R., Hanlon J.T., Artz M.B., et al. Adverse drug reaction risk factors in older outpatients. Am J Geriatr Pharmacother 1 2 (2003) 82-89
13. Seymour R.M., and Routledge P.A. Important drug-drug interactions in the elderly. Drugs Aging 12 (1998) 485-494
14. Goldberg R.M., Mabee J., Chan L., et al. Drug-drug and drug-disease interactions in the ED: analysis of a high-risk population. Am J Emerg Med 14 5 (1996) 447-450
15. Heninger-Rothbucher D., Bischinger S., Ulmer H., et al. Incidence and risk of potential adverse drug interactions in the emergency room. Resuscitation 49 3 (2001) 283-288
16. Turnheim K. Drug dosage in the elderly. Is it rational?. Drugs Aging 3 (1998) 357-379
17. Hammerlein A., Derendorf H., and Lowenthal D.T. Pharmacokinetic and pharmacodynamic changes in the elderly. Clinical implications. Clin Pharmacokinet 35 (1998) 49-64
18. Jacob S., and Spinier S.A. Hyponatremia associated with selective serotonin-reuptake inhibitors in older adults. Ann Pharmacother 40 (2006) 1618-1622
19. Sandson N.B. Appendix A. P450 tables. Drug interactions casebook. The cytochrome P450 system and beyond (2003), American Psychiatric Publishing, Inc., Washington, DC 251-269
20. Curtis L.H., Ostbye T., Sendersky V., et al. Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients. Am J Med 114 2 (2003) 135-141
21. Straus S.M., Kors J.A., De Bruin M.L., et al. Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol 47 2 (2006) 362-367
22. Rautaharju P.M., Prineas R.J., Kadish A., et al. Normal standards for QT and QT subintervals derived from a large ethnically diverse population of women aged 50 to 79 years (the Women's Health Initiative [WHI]). Am J Cardiol 97 5 (2006) 730-737
23. Yavuz B., Deveci O.S., Yavuz B.B., et al. QT dispersion increases with aging. Ann Noninvasive Electrocardiol 11 2 (2006) 127-131
24. Thomas D., Karle C.A., and Kiehn J. The cardiac hERG/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications. Curr Pharm Des 12 18 (2006) 2271-2283
25. Antonelli D., Atar S., Freedberg N.A., et al. Torsade de pointes in patients on chronic amiodarone treatment: contributing factors and drug interactions. Isr Med Assoc J 7 3 (2005) 163-165
26. Kuryshev Y.A., Ficker E., Wang L., et al. Pentamidine-induced long QT syndrome and block of hERG trafficking. J Pharmacol Exp Ther 312 1 (2005) 316-323
27. Dumontet J., Malyuk R., Kiang G., et al. Corrected QT intervals in newly admitted geriatric psychiatric patients: an examination of risk factors. Can J Psychiatry 51 6 (2006) 371-376
28. Clancy C. Electocardiographic principles. Goldfrank's toxicologic emergencies. 8th edition (2006), McGraw-Hill 57
29. McCrory D.C., Matchar D.B., Samsa G., et al. Physician attitudes about anticoagulation for nonvalvular atrial fibrillation in the elderly. Arch Intern Med 155 (1995) 277-281
30. Hanlon J.T., Pieper C.F., Hajjar E.R., et al. Incidence and predictors of all and preventable adverse drug reactions in frail elderly after hospital stay. J Gerontol A Biol Sci Med Sci 61 5 (2006) 511-515
31. Torn M., Bollen W.L., van der Meer F.J., et al. Risk of oral anticoagulant therapy with increasing age. Arch Intern Med 165 (2005) 1527-1532
32. Froom P., Miron E., and Barak M. Oral anticoagulants in the elderly. Br J Haematol 120 (2003) 526-528
33. Man-Son-Hing M., Nichol G., Lau A., et al. Choosing antithrombotic therapy for elderly patients with atrial fibrillation who are at risk for falls. Arch Intern Med 159 (1999) 677-685
34. Whitlon D.S., Sadowski J.A., and Suttie J.W. Mechanisms of coumarin action: significance of vitamin K epoxide reductase inhibition. Biochemistry 17 (1978) 1371-1377
35. Kaminsky L.S., and Shang S.-Y. Human P450 metabolism of warfarin. Pharmacol Ther 73 (1997) 67-74
36. Ansell J., Hirsch J., Poller L., et al. The pharmacology and management of the vitamin K antagonists. The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126 (2004) 204S-233S
37. Fugh-Berman A. Herb-drug interactions. Lancet 355 (2000) 134-138
38. Greenblatt D.J., and von Moltke L.L. Interaction of warfarin with drugs, natural substances, and foods. J Clin Pharmacol 45 (2005) 127-132
39. Whitling A.M., Bussey H.I., and Lyons R.M. Comparing different routes and doses of phytonadione for reversing excessive anticoagulation. Arch Intern Med 158 (1998) 2136-2140
40. Raj G., Kumar R., and McKinney P. Time course of reversal of anticoagulant effect of warfarin by intravenous and subcutaneous phytonadione. Arch Intern Med 159 (1999) 2721-2724
41. Fihn S.D., McDonell M., Martin D., et al. Risk factors for complications of chronic anticoagulation: a multicenter study. Warfarin Optimized Outpatient Follow-up Study Group. Ann Intern Med 118 (1993) 511-520
42. Remillard A.J. A pharmacoepidemiological evaluation of anticholinergic prescribing patterns in the elderly. Pharmacoepidemiol Drug Saf 5 3 (1998) 155-164
43. Ness J., Hoth A., Barnett M.J., et al. Anticholinergic medications in community-dwelling older veterans. Prevalence of anticholinergic symptoms, symptom burden, and adverse drug events. Am J Geriatr Pharmacother 4 1 (2006) 42-51
44. Blazer D.G., Federspiel C.F., Ray W.A., et al. The risk of anticholinergic toxicity in the elderly: a study of prescribing practices in two populations. J Gerontol 38 (1983) 31-35
45. Tune L., Carr S., Hoag E., et al. Anticholinergic effects of drugs commonly prescribed for the elderly: potential means for assessing risk of delirium. Am J Psychiatry 149 (1992) 1393-1394
46. Mintzer J., and Burns A. Anticholinergic side-effects of drugs in elderly patients. J R Soc Med 93 (2000) 457-462
47. Scheife R., and Takeda M. Central nervous system safety of anticholinergic drugs for the treatment of overactive bladder in the elderly. Clin Ther 27 2 (2005) 144-153
48. Moore A.R., and O'Keeffe S.T. Drug-induced cognitive impairment in the elderly. Drugs Aging 15 1 (1999) 15-28
49. Flaherty J.H. Commonly prescribed and over-the-counter medications: causes of confusion. Clin Geriatr Med 14 1 (1998) 101-127
50. Gill S., Mamdani M., Naglie G., et al. A prescribing cascade involving cholinesterase inhibitors and anticholinergic drugs. Arch Intern Med 165 7 (2005) 808-813
51. Aizenberg D., Sigler M., Weizman A., et al. Anticholinergic burden and the risk of falls among elderly psychiatric inpatients: a 4-year case-control study. Int Psychogeriatr 14 3 (2002) 307-310
52. Lechevallier-Michel N., Molimard M., Dartigues J.F., et al. Drugs with anticholinergic properties and cognitive performance in the elderly: result for the PAQUID study. Br J Clin Pharmacol 59 2 (2004) 143-151
53. Inouye S.K. Delirium in older persons. N Engl J Med 354 11 (2006) 1157-1165
54. Han L., McCusker J., Cole M., et al. Use of medications with anticholinergic effect predicts clinical severity of delirium symptoms in older medical inpatients. Arch Intern Med 161 8 (2001) 1099-1105
55. Kragh A. Two out of three persons living in nursing homes for the elderly are treated with at least ten different drugs. A survey of drug prescriptions in the northeastern part of Skane. Lakartidningen 101 (2004) 994-999
56. Ziere G., Dieleman J.P., Hofman A., et al. Polypharmacy and falls in the middle age and elderly population. Br J Clin Pharmacol 61 (2006) 218-223
57. Portenoy R.K., and Pain R. Acute and chronic pain. In: Lowinson J.H., Ruiz P., and Millman R.B. (Eds). Substance abuse: a comprehensive textbook. 2nd edition (1992), Williams and Wilkins, Baltimore (MD) 691-721
58. Ensrud K.E., Blackwell T.L., Mangione C.M., et al. Central nervous system-active medications and risk for falls in older women. J Am Geriatr Soc 50 (2002) 1629-1637
59. Miller R.R., Feingold A., and Paxinos J. Propoxyphene hydrochloride. A critical review. JAMA 213 (1970) 996-1006
60. Schnitzer T.J. Tramadol: role in the management of pain in elderly patients. Home Health Care Consult 7 (2000) 27-34
61. Shorr R.I., Griffin M.R., Daugherty J.R., et al. Opioid analgesics and risk of hip fracture in the elderly: codeine and propoxyphene. J Gerontol 47 (1992) M111-M115
62. Madhusoodanan S., and Boqunovic O.J. Safety of benzodiazepines in the geriatric population. Expert Opin Drug Saf 3 (2004) 485-493
63. Breimer D.D., and Jochemsen R. Clinical pharmacokinetics of hypnotic benzodiazepines: a summary. Br J Clin Pharmacol 16 (1983) 277S-278S
64. Greenblatt D.J., Harmatz J.S., and Shader R.I. Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Clin Pharmacokinet 21 (1991) 164-177
65. Woerner M.G., Alvir J.M., Kane J.M., et al. Neuroleptic treatment of elderly patients. Psychopharmacol Bull 31 (1995) 333-337
66. Pollock B.G., and Mulsant B.H. Behavioral disturbances of dementia. J Geriatr Psychiatry Neurol 11 (1998) 206-212