Phosphatidate phosphatase-1 is functionally conserved in lipid synthesis and storage from human to yeast

Acta Biologica Hungarica

Volumn 65, Issue 4, 2014, Pages 481-492

  Fang, Zhijia ^a   Wang, Song ^b   Du, Xiuxiu ^a   Shi, Ping ^b   Huang, Zhiwei ^a  

^a DONGHUA UNIVERSITY   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

LPIN1; Obesity yeast model; PAH1; Phosphatidate phosphatase; Triacylglycerol

Indexed keywords

CLENBUTEROL; FAT DROPLET; LIPID; LIPIN 1; PHOSPHATIDATE PHOSPHATASE; PHOSPHATIDATE PHOSPHATASE 1; PROPRANOLOL; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; ANTIOBESITY AGENT; ENZYME INHIBITOR; LPIN1 PROTEIN, HUMAN; PAH1 PROTEIN, S CEREVISIAE; PHOSPHOLIPID; SACCHAROMYCES CEREVISIAE PROTEIN; TGL3 PROTEIN, S CEREVISIAE; TGL4 PROTEIN, S CEREVISIAE;

ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; LIPID STORAGE; LIPOGENESIS; MUTANT; NONHUMAN; OBESITY; YEAST; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; MUTATION; SACCHAROMYCES CEREVISIAE;

MAMMALIA;

ANTI-OBESITY AGENTS; ENZYME INHIBITORS; HUMANS; LIPASE; LIPOGENESIS; MUTATION; PHOSPHATIDATE PHOSPHATASE; PHOSPHOLIPIDS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRIGLYCERIDES;

EID: 84925285545     PISSN: 02365383     EISSN: 1588256X     Source Type: Journal    
DOI: 10.1556/ABiol.65.2014.4.11     Document Type: Article

References (30)

1. Adeyo, O., Horn, P. J., Lee, S. K., Binns, D. D., Chandrahas, A., Chapman, K. D., Goodman, J. M. (2011) The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets. J. Cell Biol. 192, 1043-1055.
2. Bilyk, A., Piazza, G., Bistline, R., Jr., Haas, M. (1991) Separation of cholesterol, and fatty acylglycerols, acids and amides by thin-layer chromatography. Lipids 26, 405-406.
3. Brachmann, C. B., Davies, A., Cost, G. J. Caputo, E., Li, J., Hieter, P., Boeke, J. D. (1998) Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14, 115-132.
4. Carman, G. M., Han, G. S. (2006) Roles of phosphatidate phosphatase enzymes in lipid metabolism. Trends Biochem. Sci. 31, 694-699.
5. Choi, H. S., Su, W. M., Han, G. S., Plote, D., Xu, Z., Carman, G. M. (2012) Pho85p-Pho80p phosphorylation of yeast Pah1p phosphatidate phosphatase regulates its activity, location, abundance, and function in lipid metabolism. J. Biol. Chem. 287, 11290-11301.
6. Csaki, L. S., Reue, K. (2010) Lipins: multifunctional lipid metabolism proteins. Ann. Rev. Nutr. 30, 257-272.
7. Gietz, R. D., Akio, S. (1988) New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74, 527-534.
8. Grimsey, N., Han, G. S., O'hara, L., Rochford, J. J., Carman, G. M., Siniossoglou, S. (2008) Temporal and spatial regulation of the phosphatidate phosphatases lipins 1 and 2. J. Biol. Chem. 283, 29166-29174.
9. Guo, Y., Cordes, K. R., Farese, R. V., Jr., Walther, T. C. (2009) Lipid droplets at a glance. J. Cell Sci. 122, 749-752.
10. Huang, Z., Sucgang, R. S., Lin, Y. Y., Shi, X., Boeke, J. D., Pan, X. (2008) Plasmid-chromosome shuffling for non-deletion alleles in yeast. Nat. Meth. 5, 167-169.
11. Kitazono, A. A. (2009) Improved gap-repair cloning method that uses oligonucleotides to target cognate sequences. Yeast 26, 497-505.
12. Kohlwein, S. D. (2010) Triacylglycerol homeostasis: insights from yeast. J. Biol. Chem. 285, 15663-15667.
13. Kurat, C. F., Natter, K., Petschnigg, J., Wolinski, H., Scheuringer, K., Scholz, H., Zimmermann, R., Leber, R., Zechner, R., Kohlwein, S. D. (2006) Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast. J. Biol. Chem. 281, 491-500.
14. Nanjundan, M., Possmayer, F. (2003) Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase. Am. J. Physiol. Lung Cell. Mol. Physiol. 284, L1-L23.
15. O'hara, L., Han, G. S., Peak-Chew, S., Grimsey, N., Carman, G. M., Siniossoglou, S. (2006) Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+-dependent phosphatidate phosphatase. J. Biol. Chem. 281, 34537-34548.
16. Phan, J., Reue, K. (2005) Lipin, a lipodystrophy and obesity gene. Cell Metab. 1, 73-83.
17. Pyne, S., Long, J. S., Ktistakis, N. T., Pyne, N. J. (2005) Lipid phosphate phosphatases and lipid phosphate signalling. Biochem. Soc. Trans. 33, 1370-1374.
18. Reue, K., Dwyer, J. R. (2009) Lipin proteins and metabolic homeostasis. J. Lipid Res. 50 Suppl, S109-S114.
19. Santos-Rosa, H., Leung, J., Grimsey, N., Peak-Chew, S., Siniossoglou, S. (2005) The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth. EMBO J. 24, 1931-1941.
20. Sasser, T., Qiu, Q. S., Karunakaran, S., Padolina, M., Reyes, A., Flood, B., Smith, S., Gonzales, C., Fratti, R. A. (2012) Yeast lipin 1 orthologue pah1p regulates vacuole homeostasis and membrane fusion. J. Biol. Chem. 287, 2221-2236.
21. Schneiter, R., Daum, G. (2006) Extraction of yeast lipids. Methods Mol. Biol. 313, 41-45.
22. Sciorra, V. A., Morris, A. J. (2002) Roles for lipid phosphate phosphatases in regulation of cellular signaling. Biochim. Biophys. Acta 1582, 45-51.
23. Shahnazari, S., Yen, W. L., Birmingham, C. L., Shiu, J., Namolovan, A., Zheng, Y. T., Nakayama, K., Klionsky, D. J., Brumell, J. H. (2010) A diacylglycerol-dependent signaling pathway contributes to regulation of antibacterial autophagy. Cell Host Microbe 8, 137-146.
24. Siniossoglou, S. (2013) Phospholipid metabolism and nuclear function: roles of the lipin family of phosphatidic acid phosphatases. Biochim. Biophys. Acta 1831, 575-581.
25. Skinner, J. R., Shew, T. M., Schwartz, D. M., Tzekov, A., Lepus, C. M., Abumrad, N. A., Wolins, N. E. (2009) Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization. J. Biol. Chem. 284, 30941-30948.
26. Suviolahti, E., Reue, K., Cantor, R. M., Phan, J., Gentile, M., Naukkarinen, J., Soro-Paavonen, A., Oksanen, L., Kaprio, J., Rissanen, A., Salomaa, V., Kontula, K., Taskinen, M. R., Pajukanta, P., Peltonen, L. (2006) Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism. Hum. Mol. Genet. 15, 377-386.
27. Sztalryd, C., Xu, G., Dorward, H., Tansey, J. T., Contreras, J. A., Kimmel, A. R., Londos, C. (2003) Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. J. Cell Biol. 161, 1093-1103.
28. Wolinski, H., Kohlwein, S. D. (2008) Microscopic analysis of lipid droplet metabolism and dynamics in yeast. Methods Mol. Biol. 457, 151-163.
29. Zeharia, A., Shaag, A., Houtkooper, R. H., Hindi, T., De Lonlay, P., Erez, G., Hubert, L., Saada, A., De Keyzer, Y., Eshel, G., Vaz, F. M., Pines, O., Elpeleg, O. (2008) Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood. Am. J. Hum. Genet. 83, 489-494.
30. Zimmermann, R., Strauss, J. G., Haemmerle, G., Schoiswohl, G., Birner-Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., Zechner, R. (2004) Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306, 1383-1386.