Shedding light on the dock-lock mechanism in amyloid fibril growth using Markov state models

Journal of Physical Chemistry Letters

Volumn 6, Issue 6, 2015, Pages 1076-1081

  Schor, Marieke ^a   Mey, Antonia S J S ^b   Noé, Frank ^b   Macphee, Cait E ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

amyloid fibril; Markov state model; metastability; molecular dynamics; pH

Indexed keywords

MOLECULAR DYNAMICS; MONOMERS; PEPTIDES; PH;

ALL-ATOM SIMULATIONS; AMYLOID FIBRIL; AMYLOID FIBRIL GROWTH; HYDROPHOBIC RESIDUES; MARKOV STATE MODELS; METASTABILITIES; MOLECULAR MECHANISM; MULTIPLE PATHWAYS;

GLYCOPROTEINS;

AMYLOID; PREALBUMIN;

CHEMISTRY; MARKOV CHAIN; METABOLISM; MOLECULAR DOCKING; PH; PROTEIN MULTIMERIZATION; STATISTICAL MODEL;

AMYLOID; HYDROGEN-ION CONCENTRATION; MARKOV CHAINS; MODELS, STATISTICAL; MOLECULAR DOCKING SIMULATION; PREALBUMIN; PROTEIN MULTIMERIZATION;

EID: 84925264398     PISSN: None     EISSN: 19487185     Source Type: Journal    
DOI: 10.1021/acs.jpclett.5b00330     Document Type: Article

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