Thermodynamic perspective on the dock-lock growth mechanism of amyloid fibrils

Journal of Physical Chemistry B

Volumn 113, Issue 43, 2009, Pages 14421-14430

  O'Brien, Edward P ^a,b   Okamoto, Yuko ^c   Straub, John E ^d   Brooks, Bernard R ^b   Thirumalai, D ^a,d  

^a Bldg 142   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c NAGOYA UNIVERSITY   (Japan)

^d Boston University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; CRYSTAL STRUCTURE; DOCKS; GLYCOPROTEINS; HYDRAULIC STRUCTURES; MOLECULAR DYNAMICS; MONOMERS; PEPTIDES; POLYPEPTIDES; SIMULATORS; SURFACE STRUCTURE; THERMODYNAMICS; UREA;

AMYLOID FIBRIL; BASINS OF ATTRACTION; CENTER OF MASS; CO-SOLUTES; COMPLEX PROCESSES; CONFORMATIONAL FLUCTUATIONS; EXPLICIT WATER; FAVORABLE INTERACTIONS; FIBRIL GROWTH; GROWTH MECHANISMS; IMPLICIT SOLVENT MODEL; LOCK MECHANISM; MOLECULAR DYNAMICS SIMULATIONS; MONOMER CONCENTRATION; MULTISTEP PROCESS; ORDER PARAMETER; PEPTIDE FIBRILS; PEPTIDE FRAGMENTS; REVERSIBLE ASSOCIATIONS; SAMPLING METHOD; SOLUTION CONDITIONS; TIME SCALE SEPARATION;

CONFORMATIONS;

EID: 70350381490     PISSN: 15206106     EISSN: None     Source Type: Journal    
DOI: 10.1021/jp9050098     Document Type: Article

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