Early predictors of outcome in infants treated with hypothermia for hypoxic-ischaemic encephalopathy

Developmental Medicine and Child Neurology

Volumn 57, Issue S3, 2015, Pages 8-16

  Merchant, Nazakat ^a,b   Azzopardi, Denis ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b WEST HERTFORDSHIRE HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; NEURON SPECIFIC ENOLASE; PROTEIN S100B; BIOLOGICAL MARKER;

APGAR SCORE; ARTICLE; BRAIN FUNCTION; BRAIN INJURY; CLINICAL ASSESSMENT; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE SEVERITY; ECHOGRAPHY; ELECTROENCEPHALOGRAPHY; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INDUCED HYPOTHERMIA; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PERINATAL ASPHYXIA; PREDICTIVE VALUE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; REM SLEEP; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME; BRAIN; COMPLICATION; HYPOXIA-ISCHEMIA, BRAIN; INFANT; METABOLISM; NERVOUS SYSTEM DISEASES; NEWBORN; PATHOLOGY; STATISTICS AND NUMERICAL DATA;

BIOLOGICAL MARKERS; BRAIN; HUMANS; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; INFANT; INFANT, NEWBORN; NERVOUS SYSTEM DISEASES; PREDICTIVE VALUE OF TESTS; TREATMENT OUTCOME;

EID: 84925245351     PISSN: 00121622     EISSN: 14698749     Source Type: Journal    
DOI: 10.1111/dmcn.12726     Document Type: Article

References (53)

1. National Institute for Health and Clinical Excellence. Therapeutic hypothermia with intracorporeal temperature monitoring for hypoxic perinatal brain injury. http://www.nice.org.uk/nicemedia/live/11315/48809/48809.pdf (accessed 1 February 2014).
2. Ehrenstein V, Pedersen L, Grijota M, Nielsen GL, Rothman KJ, Sorensen HT. Association of Apgar score at five minutes with long-term neurological disability and cognitive function in a prevalence study of Danish conscripts. BMC Pregnancy Childbirth 2009; 9: 14.
3. Moster D, Lie RT, Irgens LM, Bjerkedal T, Markestad T. The association of Apgar score with subsequent death and cerebral palsy: a population-based study in term infants. J Pediatr 2001; 138: 798-803.
4. Ruth VJ, Raivio KO. Perinatal brain damage: predictive value of metabolic acidosis and the Apgar score. Br Med J 1988; 297: 24-7.
5. Saugstad OD, Ramji S, Rootwelt T, Vento M. Response to resuscitation of the newborn: early prognostic variables. Acta Paediatr 2005; 94: 890-5.
6. Shah PS, Beyene J, To T, Ohlsson A, Perlman M. Postasphyxial hypoxic-ischaemic encephalopathy in neonates: outcome prediction rule within 4 hours of birth. Arch Pediatr Adolesc Med 2006; 160: 729-36.
7. Azzopardi DV, Strohm B, Edwards AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009; 361: 1349-58.
8. Jacobs SE, Morley CJ, Inder TE, et al. Whole-body hypothermia for term and near-term newborns with hypoxic-ischaemic encephalopathy: a randomized controlled trial. Arch Pediatr Adolesc Med 2011; 165: 692-700.
9. Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischaemic encephalopathy. N Engl J Med 2005; 353: 1574-84.
10. Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomized trial. Lancet 2005; 365: 663-70.
11. Simbruner G, Mittal RA, Rohlmann F, Muche R, neo.nEURO.network Trial Participants. Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT. Pediatrics 2010; 126: e771-8.
12. Shankaran S, Pappas A, Laptook AR, et al. Outcomes of safety and effectiveness in a multicenter randomized, controlled trial of whole-body hypothermia for neonatal hypoxic-ischaemic encephalopathy. Pediatrics 2008; 122: e791-8.
13. Shankaran S, Laptook AR, Tyson JE, et al. Evolution of encephalopathy during whole body hypothermia for neonatal hypoxic-ischaemic encephalopathy. J Pediatr 2012; 160: 567-72.e3.
14. Natarajan G, Shankaran S, Laptook AR, et al. Apgar scores at 10 min and outcomes at 6-7 years following hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 2013; 98: F473-9.
15. Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol 1976; 33: 696-705.
16. Shalak LF, Laptook AR, Velaphi SC, Perlman JM. Amplitude-integrated electroencephalography coupled with an early neurological examination enhances prediction of term infants at risk for persistent encephalopathy. Pediatrics 2003; 111: 351-7.
17. Thompson CM, Puterman AS, Linley LL, et al. The value of a scoring system for hypoxic ischaemic encephalopathy in predicting neurodevelopmental outcome. Acta Paediatr 1997; 86: 757-61.
18. Miller SP, Latal B, Clark H, et al. Clinical signs predict 30-month neurodevelopmental outcome after neonatal encephalopathy. Am J Obstet Gynecol 2004; 190: 93-9.
19. van de Riet JE, Vandenbussche FP, Le Cessie S, Keirse MJ. Newborn assessment and long-term adverse outcome: a systematic review. Am J Obstet Gynecol 1999; 180: 1024-9.
20. Azzopardi D, Strohm B, Edwards AD, et al. Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: how cooling is managed in the UK outside a clinical trial. Arch Dis Child Fetal Neonatal Ed 2009; 94: F260-4.
21. Gunn AJ, Wyatt JS, Whitelaw A, et al. Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy. J Pediatr 2008; 152: 55-8, 58.e1.
22. Toet MC, Hellstrom-Westas L, Groenendaal F, Eken P, de Vries LS. Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 1999; 81: F19-23.
23. van Laerhoven H, de Haan TR, Offringa M, Post B, van der Lee JH. Prognostic tests in term neonates with hypoxic-ischaemic encephalopathy: a systematic review. Pediatrics 2013; 131: 88-98.
24. Cseko AJ, Bango M, Lakatos P, Kardasi J, Pusztai L, Szabo M. Accuracy of amplitude-integrated electroencephalography in the prediction of neurodevelopmental outcome in asphyxiated infants receiving hypothermia treatment. Acta Paediatr 2013; 102: 707-11.
25. Thoresen M, Hellstrom-Westas L, Liu X, de Vries LS. Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia. Pediatrics 2010; 126: e131-9.
26. Azzopardi D. Predictive value of the amplitude integrated EEG in infants with hypoxic ischaemic encephalopathy: data from a randomized trial of therapeutic hypothermia. Arch Dis Child Fetal Neonatal Ed 2014; 99: F80-2.
27. Hallberg B, Grossmann K, Bartocci M, Blennow M. The prognostic value of early aEEG in asphyxiated infants undergoing systemic hypothermia treatment. Acta Paediatr 2010; 99: 531-6.
28. Glass HC, Glidden D, Jeremy RJ, Barkovich AJ, Ferriero DM, Miller SP. Clinical neonatal seizures are independently associated with outcome in infants at risk for hypoxic-ischaemic brain injury. J Pediatr 2009; 155: 318-23.
29. Shah DK, Wusthoff CJ, Clarke P, et al. Electrographic seizures are associated with brain injury in newborns undergoing therapeutic hypothermia. Arch Dis Child Fetal Neonatal Ed 2014; 99: F219-24.
30. Reynolds PR, Dale RC, Cowan FM. Neonatal cranial ultrasound interpretation: a clinical audit. Arch Dis Child Fetal Neonatal Ed 2001; 84: F92-5.
31. Jongeling BR, Badawi N, Kurinczuk JJ, et al. Cranial ultrasound as a predictor of outcome in term newborn encephalopathy. Pediatr Neurol 2002; 26: 37-42.
32. Allison JW, Seibert JJ. Transcranial Doppler in the newborn with asphyxia. Neuroimaging Clin N Am 1999; 9: 11-6.
33. Archer LN, Evans DH, Levene MI. Doppler ultrasound examination of the anterior cerebral arteries of normal newborn infants: the effect of postnatal age. Early Hum Dev 1985; 10: 255-60.
34. Elstad M, Whitelaw A, Thoresen M. Cerebral Resistance Index is less predictive in hypothermic encephalopathic newborns. Acta Paediatr 2011; 100: 1344-9.
35. Rutherford M. The asphyxiated infant. In: Rutherford M, editor. MRI of the Neonatal Brain. Philadelphia, PA: WB Saunders, 2002: 99-123.
36. Rutherford MA, Pennock JM, Schwieso JE, Cowan FM, Dubowitz LM. Hypoxic ischaemic encephalopathy: early magnetic resonance imaging findings and their evolution. Neuropediatrics 1995; 26: 183-91.
37. Porter EJ, Counsell SJ, Edwards AD, Allsop J, Azzopardi D. Tract-based spatial statistics of magnetic resonance images to assess disease and treatment effects in perinatal asphyxial encephalopathy. Pediatr Res 2010; 68: 205-9.
38. Tusor N, Wusthoff C, Smee N, et al. Prediction of neurodevelopmental outcome after hypoxic-ischaemic encephalopathy treated with hypothermia by diffusion tensor imaging analysed using tract-based spatial statistics. Pediatr Res 2012; 72: 63-9.
39. Cheong JL, Coleman L, Hunt RW, et al. Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischaemic encephalopathy: substudy of a randomized trial. Arch Pediatr Adolesc Med 2012; 166: 634-40.
40. Rutherford M, Ramenghi LA, Edwards AD, et al. Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomized controlled trial. Lancet Neurol 2010; 9: 39-45.
41. Ramaswamy V, Horton J, Vandermeer B, Buscemi N, Miller S, Yager J. Systematic review of biomarkers of brain injury in term neonatal encephalopathy. Paediatr Neurol 2009; 40: 215-26.
42. Nagdyman N, Grimmer I, Scholz T, Muller C, Obladen M. Predictive value of brain-specific proteins in serum for neurodevelopmental outcome after birth asphyxia. Pediatr Res 2003; 54: 270-5.
43. Gazzolo D, Marinoni E, Di Iorio R, et al. Measurement of urinary S100B protein concentrations for the early identification of brain damage in asphyxiated full-term infants. Arch Pediatr Adolesc Med 2003; 157: 1163-8.
44. Celtik C, Acunas B, Oner N, Pala O. Neuron-specific enolase as a marker of the severity and outcome of hypoxic ischaemic encephalopathy. Brain Dev 2004; 26: 398-402.
45. Walsh P, Jedeikin R, Ellis G, Primhak R, Makela SK. Assessment of neurological outcome in asphyxiated term infants by use of serial CK-BB isoenzyme measurement. J Pediatr 1982; 101: 988-92.
46. Massaro AN, Jeromin A, Kadom N, et al. Serum biomarkers of MRI brain injury in neonatal hypoxic ischaemic encephalopathy treated with whole-body hypothermia: a pilot study. Pediatr Crit Care Med 2013; 14: 310-7.
47. Chiesa C, Pellegrini G, Panero A, et al. Umbilical cord interleukin-6 levels are elevated in term neonates with perinatal asphyxia. Eur J Clin Invest 2003; 33: 352-8.
48. Savman K, Blennow M, Gustafson K, Tarkowski E, Hagberg H. Cytokine response in cerebrospinal fluid after birth asphyxia. Pediatr Res 1998; 43: 746-51.
49. Bartha AI, Foster-Barber A, Miller SP, et al. Neonatal encephalopathy: association of cytokines with MR spectroscopy and outcome. Pediatr Res 2004; 56: 960-6.
50. Chalak LF, Sanchez PJ, Adams-Huet B, Laptook AR, Heyne RJ, Rosenfeld CR. Biomarkers for severity of neonatal hypoxic-ischaemic encephalopathy and outcomes in newborns receiving hypothermia therapy. J Pediatr 2013; 164: 468-74.
51. Roka A, Beko G, Halasz J, et al. Changes in serum cytokine and cortisol levels in normothermic and hypothermic term neonates after perinatal asphyxia. Inflamm Res 2013; 62: 81-7.
52. Papa L, Akinyi L, Liu MC, et al. Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury. Crit Care Med 2010; 38: 138-44.
53. Fraser DD, Close TE, Rose KL, et al. Severe traumatic brain injury in children elevates glial fibrillary acidic protein in cerebrospinal fluid and serum. Pediatr Crit Care Med 2011; 12: 319-24.