IGF-I regulates the age-dependent signaling peptide humanin

Aging Cell

Volumn 13, Issue 5, 2014, Pages 958-961

  Lee, Changhan ^a   Wan, Junxiang ^a   Miyazaki, Brian ^b   Fang, Yimin ^c   Guevara Aguirre, Jaime ^d,e   Yen, Kelvin ^a   Longo, Valter ^a   Bartke, Andrzej ^c   Cohen, Pinchas ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

^c SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSIDAD SAN FRANCISCO DE QUITO   (Ecuador)

^e Instituto de Endocrinología IEMYR   (Ecuador)

Author keywords

Aging; Growth hormone; Humanin; IGF I; Longevity

Indexed keywords

GROWTH HORMONE; HUMANIN; SOMATOMEDIN C; SIGNAL PEPTIDE;

AGE; AGING; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY SIZE; BODY WEIGHT; CANCER INCIDENCE; CHILD; CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; LIFESPAN; LONGEVITY; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; REGULATORY MECHANISM; SHORT STATURE; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; METABOLISM;

MUS; MUS MUSCULUS;

AGE FACTORS; ANIMALS; GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; MODELS, ANIMAL;

EID: 84925234758     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12243     Document Type: Article

References (18)

1. Bartke A (2003) Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice. Neuroendocrinology 78, 210-216.
2. Bartke A, Brown-Borg H (2004) Life extension in the dwarf mouse. Curr. Top. Dev. Biol. 63, 189-225.
3. Bratic A, Larsson NG (2013) The role of mitochondria in aging. J. Clin. Invest. 123, 951-957.
4. Chin YP, Keni J, Wan J, Mehta H, Anene F, Jia Y, Lue YH, Swerdloff R, Cobb LJ, Wang C, Cohen P (2013) Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents. Endocrinology 154, 3739-3744.
5. Cohen P (2014) A potential new role for the mitochondrial peptide humanin as a protective agent against chemotherapy-induced side effects. J. Natl. Cancer Inst. 106, dju006.
6. Durieux J, Wolff S, Dillin A (2011) The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 144, 79-91.
7. Eriksson E, Wickström M, Segerström-Perup L, Johnsen JI, Eksborg S, Kogner P, Sävendahl L (2014) Protective role of Humanin on bortezomib-induced bone growth impairment in anti-cancer treatment. J. Natl. Cancer Inst. 106, djt459.
8. Fontana L, Partridge L, Longo VD (2010) Extending healthy life span-from yeast to humans. Science 328, 321-326.
9. Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD (2011) Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci. Transl. Med. 3, 70ra13.
10. Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang J, Kurokawa K, Nishimoto I (2001) A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proc. Natl Acad. Sci. USA 98, 6336-6341.
11. Kennedy SR, Salk JJ, Schmitt MW, Loeb LA (2013) Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage. PLoS Genet. 9, e1003794.
12. Lee C, Yen K, Cohen P (2013) Humanin: a harbinger of mitochondrial-derived peptides? Trends Endocrinol. Metab. 24, 222-228.
13. Mehta HH, Gao Q, Galet C, Paharkova V, Wan J, Said J, Sohn JJ, Lawson G, Cohen P, Cobb LJ, Lee KW (2011) IGFBP-3 is a metastasis suppression gene in prostate cancer. Cancer Res. 71, 5154-5163.
14. Muzumdar RH, Huffman DM, Atzmon G, Buettner C, Cobb LJ, Fishman S, Budagov T, Cui L, Einstein FH, Poduval A, Hwang D, Barzilai N, Cohen P (2009) Humanin: a novel central regulator of peripheral insulin action. PLoS ONE 4, e6334.
15. Oh YK, Bachar AR, Zacharias DG, Kim SG, Wan J, Cobb LJ, Lerman LO, Cohen P, Lerman A (2011) Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice. Atherosclerosis 219, 65-73.
16. Sanz A, Bartke A, Barja G (2002) Long-lived Ames dwarf mice: oxidative damage to mitochondrial DNA in heart and brain. J. Am. Aging Assoc. 25, 119-122.
17. Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, LeRoith D (1999) Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc. Natl Acad. Sci. USA 96, 7324-7329.
18. Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D (2009) Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB J. 23, 709-719.