Detection of drug-resistant tuberculosis by xpert MTB/RIF in Swaziland

New England Journal of Medicine

Volumn 372, Issue 12, 2015, Pages 1181-1182

  Sanchez Padilla, Elisabeth ^a   Merker, Matthias ^b   Beckert, Patrick ^b   Jochims, Frauke ^c   Dlamini, Themba ^d   Kahn, Patricia ^c   Bonnet, Maryline ^a   Niemann, Stefan ^b  

^a EPICENTRE   (France)

^b RESEARCH CENTER BORSTEL   (Germany)

^c MÉDECINS SANS FRONTIÈRES   (Switzerland)

^d National Tuberculosis Control Program   (Swaziland)

Author keywords

[No Author keywords available]

Indexed keywords

ISONIAZID; RIFAMPICIN; RNA POLYMERASE BETA SUBUNIT; DNA; TUBERCULOSTATIC AGENT;

ANTIBIOTIC RESISTANCE; BACTERIAL STRAIN; BACTERIAL TRANSMISSION; DRUG RESISTANT TUBERCULOSIS; GENE MUTATION; GENETIC ANALYSIS; GENOME SIZE; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERSPERSED REPEAT; LETTER; MIXED INFECTION; MULTIDRUG RESISTANCE; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; RPOB GENE; SWAZILAND; TUBERCULOSIS RAPID TEST; VARIABLE NUMBER OF TANDEM REPEAT; GENETICS; ISOLATION AND PURIFICATION; MICROBIOLOGY; NUCLEOTIDE SEQUENCE; PROCEDURES; TANDEM REPEAT; TUBERCULOSIS, MULTIDRUG-RESISTANT;

ANTIBIOTICS, ANTITUBERCULAR; DNA; DNA MUTATIONAL ANALYSIS; HUMANS; MYCOBACTERIUM TUBERCULOSIS; RIFAMPIN; SWAZILAND; TANDEM REPEAT SEQUENCES; TUBERCULOSIS, MULTIDRUG-RESISTANT;

EID: 84925067886     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1413930     Document Type: Letter

References (5)

1. Boehme CC, Nabeta P, Hillemann D, et al. Rapid molecular detection of tuberculosis and rifampin resistance. N Engl J Med 2010;363:1005-15.
2. Monitoring of Xpert MTB/RIF roll-out, Swaziland. Geneva: World Health Organization, 2013 (http://www.stoptb.org/wg/gli/assets/documents/map/2/Pdf-files/SWZ.pdf).
3. Sanchez-Padilla E, Dlamini T, Ascorra A, et al. High prevalence of multidrug-resistant tuberculosis, Swaziland, 2009-2010. Emerg Infect Dis 2012;18:29-37.
4. Siu GKH, Zhang Y, Lau TCK, et al. Mutations outside the rifampicin resistance-determining region associated with rifampicin resistance in Mycobacterium tuberculosis. J Antimicrob Chemother 2011;66:730-3.
5. Policy statement: automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF system. Geneva: World Health Organization, 2011.