Rescue of the temperature-sensitive, autosomal-recessive mutation R298S in the sodium-bicarbonate cotransporter NBCe1-A characterized by a weakened dimer and abnormal aggregation

Biochimica et Biophysica Acta - General Subjects

Volumn 1850, Issue 6, 2015, Pages 1286-1296

  Gill, Harindarpal S ^a   Choi, Kun Young ^a   Kammili, Lakshmi ^a   Popratiloff, Anastas ^a  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

Composition gradient light scattering; Confocal microscopy; Protein aggregation; X ray crystallography

Indexed keywords

BICARBONATE SODIUM COTRANSPORTER; BICARBONATE SODIUM COTRANSPORTER NBCE1 A; DIMER; UNCLASSIFIED DRUG; COLLOID; HYBRID PROTEIN; PROTEIN AGGREGATE; SLC4A4 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOSOMAL RECESSIVE INHERITANCE; CELL LEVEL; CELL MIGRATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORNEA ENDOTHELIUM; CRYSTAL STRUCTURE; CYTOPLASM; DIMERIZATION; DISEASE ASSOCIATION; DISSOCIATION CONSTANT; ENDOTHELIUM CELL; EYE DISEASE; GENE MUTATION; HUMAN; HUMAN CELL; KIDNEY TUBULE ACIDOSIS; KIDNEY TUBULE CELL; MELTING POINT; MEMBRANE FORMATION; MEMBRANE TRANSPORT; MOLECULAR WEIGHT; PH; PRECIPITATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; STRUCTURE ANALYSIS; TEMPERATURE; TEMPERATURE SENSITIVITY; THERMOSTABILITY; TYPE II KIDNEY TUBULE ACIDOSIS; CELL LINE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COLLOID; COMPUTER SIMULATION; GENETIC TRANSFECTION; GENETICS; GENOTYPE; HYDROGEN BOND; KIDNEY PROXIMAL TUBULE; KINETICS; METABOLISM; MUTATION; PHENOTYPE; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN TRANSPORT; TRANSITION TEMPERATURE;

CELL LINE; COLLOIDS; COMPUTER SIMULATION; ENDOTHELIUM, CORNEAL; GENOTYPE; HUMANS; HYDROGEN BONDING; KIDNEY TUBULES, PROXIMAL; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTATION; PHENOTYPE; PROTEIN AGGREGATES; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SODIUM-BICARBONATE SYMPORTERS; TRANSFECTION; TRANSITION TEMPERATURE;

EID: 84925017874     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2015.02.014     Document Type: Article

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