Functional roles of electrogenic sodium bicarbonate cotransporter NBCe1 in ocular tissues

Open Ophthalmology Journal

Volumn 6, Issue , 2012, Pages 36-41

  Suzuki, Masashi ^a   Seki, George ^a   Yamada, Hideomi ^a   Horita, Shoko ^a   Fujita, Toshiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Band keratopathy; Cataract; Glaucoma; NBCe1; Proximal renal tubular acidosis

Indexed keywords

BICARBONATE SODIUM COTRANSPORTER; BICARBONATE; CALCIUM ION; SMALL INTERFERING RNA;

ACID BASE BALANCE; APICAL MEMBRANE; BASOLATERAL MEMBRANE; CATARACT; EYE DISEASE; GENE MUTATION; GLAUCOMA; HOMOZYGOSITY; HUMAN; INTRAOCULAR PRESSURE; KERATOPATHY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ACIDOSIS; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; ARTICLE; CORNEA EDEMA; CORNEA ENDOTHELIUM; CORNEA OPACITY; CORNEA THICKNESS; GENE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIAL; METABOLIC ACIDOSIS; NBCE1 GENE; NONHUMAN; OCULAR TISSUE; PH; PHENOTYPE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRABECULAR MESHWORK;

EID: 84863797981     PISSN: None     EISSN: 18743641     Source Type: Journal    
DOI: 10.2174/1874364101206010036     Document Type: Review

References (59)

1. Boron WF, Boulpaep EL. Intracellular pH regulation in the renal proximal tubule of the salamander. Basolateral HCO3- transport. J Gen Physiol 1983; 81: 53-94.
2. +/HCO3- cotransporter. Nature 1997; 387: 409-13.
3. Abuladze N, Song M, Pushkin A, et al. Structural organization of the human NBCl gene: kNBCl is transcribed from an alternative promoter in intron 3. Gene 2000; 251: 109-22.
4. +-HCO3- cotransporter (NBC) with a novel COOH- terminus, cloned from rat brain. Am J Physiol Cell Physiol 2000; 278: C1200-11.
5. Boron WF. Acid-base transport by the renal proximal tubule. J Am Soc Nephrol 2006; 17: 2368-82.
6. Abuladze N, Lee I, Newman D, et al. Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter. J Biol Chem 1998; 273: 17689-95.
7. +-HCO3- cotransporter (NBC-1) variants in rat and human pancreas. Am J Physiol Cell Physiol 2003; 284: C729-37.
8. Usui T, Hara M, Satoh H, et al. Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis. J Clin Invest 2001; 108: 107-15.
9. Bok D, Schibler MJ, Pushkin A, et al. Immunolocalization of electrogenic sodium-bicarbonate cotransporters pNBC1 and kNBC1 in the rat eye. Am J Physiol Renal Physiol 2001; 281: F920-35.
10. +-nHCO3- cotransport in pancreatic duct cells: a basis for defective HCO3- secretion in CF. Am J Physiol Cell Physiol 1999; 276: C16-25.
11. Igarashi T, Inatomi J, Sekine T, et al. Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities. Nat Genet 1999; 23: 264-6.
12. +- HCO3- cotransport in basolateral membrane vesicles isolated from rabbit renal cortex. J Clin Invest 1987; 79: 1276-80.
13. Seki G, Coppola S, Yoshitomi K, et al. On the mechanism of bicarbonate exit from renal proximal tubular cells. Kidney Int 1996; 49: 1671-7.
14. Yoshitomi K, Burckhardt BC, Frömter E. Rheogenic sodium- bicarbonate cotransport in the peritubular cell membrane of rat renal proximal tubule. Pflugers Arch 1985; 405: 360-6.
15. Horita S, Yamada H, Inatomi J, et al. Functional analysis of NBC1 mutants associated with proximal renal tubular acidosis and ocular abnormalities. J Am Soc Nephrol 2005; 16: 2270-8.
16. Gross E, Hawkins K, Abuladze N, et al. The stoichiometry of the electrogenic sodium bicarbonate cotransporter NBC1 is cell-type dependent. J Physiol 2001; 531: 597-603.
17. Bonanno JA. Molecular mechanisms underlying the corneal endothelial pump. Exp Eye Res 2012; 95: 2-7.
18. +-HCO3- cotransporter NBCe1. Open J Mol Integr Physiol 2011; 1: 9-16.
19. +/HCO3- cotransporter gene (SLC4A4) in a patient with permanent isolated proximal renal tubular acidosis and bilateral glaucoma. J Am Soc Nephrol 2001; 12: 713-8.
20. Inatomi J, Horita S, Braverman N, et al. Mutational and functional analysis of SLC4A4 in a patient with proximal renal tubular acidosis. Pflugers Arch 2004; 448: 438-44.
21. Suzuki M, Vaisbich MH, Yamada H, et al. Functional analysis of a novel missense NBC1 mutation and of other mutations causing proximal renal tubular acidosis. Pflugers Arch 2008; 455: 583-93.
22. +-HCO3- cotransporter NBCe1 is associated with familial migraine. Proc Natl Acad Sci USA 2010; 107: 15963-8.
23. Dinour D, Chang MH, Satoh J, et al. A novel missense mutation in the sodium bicarbonate cotransporter (NBCe1/SLC4A4) causes proximal tubular acidosis and glaucoma through ion transport defects. J Biol Chem 2004; 279: 52238-46.
24. Demirci FYK, Chang MH, Mah TS, Romero MF, Gorin MB. Proximal renal tubular acidosis and ocular pathology: a novel missense mutation in the gene (SLC4A4) for sodium bicarbonate cotransporter protein (NBCe1). Mol Vis 2006; 12: 324-30.
25. Lo YF, Yang SS, Seki G, et al. Severe metabolic acidosis causes early lethality in NBC1 W516X knock-in mice as a model of human isolated proximal renal tubular acidosis. Kidney Int 2011; 79: 730-41.
26. +/HCO3- cotransporters: cloning and physiology. Annu Rev Physiol 1999; 61: 699-723.
27. Kao L, Sassani P, Azimov R, et al. Oligomeric structure and minimal functional unit of the electrogenic sodium bicarbonate cotransporter NBCe1-A. J Biol Chem 2008; 283: 26782-94.
28. Shrode LD, Putnam RW. Intracellular pH regulation in primary rat astrocytes and C6 glioma cells. Glia 1994; 12: 196-210.
29. Hodson S, Miller F. The bicarbonate ion pump in the endothelium which regulates the hydration of rabbit cornea. J Physiol 1976; 263: 563-77.
30. Bonanno JA, Guan Y, Jelamskii S, Kang XJ. Apical and basolateral CO2-HCO3- permeability in cultured bovine corneal endothelial cells. Am J Physiol 1999; 277: C545-53.
31. +-HCO3- cotransporter in bovine corneal endothelium. Am J Physiol Cell Physiol 2000; 279: C1648-55.
32. Sun XC, Bonanno JA. Identification and cloning of the Na/HCO3- cotransporter (NBC) in human corneal endothelium. Exp Eye Res 2003; 77: 287-95.
33. +-HCO3- cotransporters and carbonic anhydrase dependence of fluid transport in corneal endothelial cells. Am J Physiol Cell Physiol 2004; 286: C1434-42.
34. Li J, Sun XC, Bonanno JA. Role of NBC1 in apical and basolateral HCO3- permeabilities and transendothelial HCO3- fluxes in bovine corneal endothelium. Am J Physiol Cell Physiol 2005; 288: C739-46.
35. Liu CL, Cheng QA, Nguyen T, Bonanno JA. Knockdown of NBCe1 in vivo compromises the corneal endothelial pump. Invest Ophthalmol Vis Sci 2010; 51: 5190-7.
36. Harris JE, Hauschildt JD, Nordquist LT. Transport of glucose across the lens surfaces. Am J Ophthalmol 1955; 39: 161-9.
37. Fischbarg J, Diecke FP, Kuang K, et al. Transport of fluid by lens epithelium. Am J Physiol 1999; 276: C548-57.
38. Hughes BA, Adorante JS, Miller SS, Lin H. Apical electrogenic NaHCO3 cotransport. A mechanism for HCO3 absorption across the retinal pigment epithelium. J Gen Physiol 1989; 94: 125-50.
39. Lin H, Miller SS. pHi regulation in frog retinal pigment epithelium: two apical membrane mechanisms. Am J Physiol 1991; 261: C132-42.
40. Lin H, Kenyon E, Miller SS. Na-dependent pHi regulatory mechanisms in native human retinal pigment epithelium. Invest Ophthalmol Vis Sci 1992; 33: 3528-38.
41. Newman EA. Sodium-bicarbonate cotransport in retinal astrocytes and Müller cells of the rat. Glia 1999; 26: 302-8.
42. Shahidullah M, To CH, Pelis RM, Delamere NA. Studies on bicarbonate transporters and carbonic anhydrase in porcine nonpigmented ciliary epithelium. Invest Ophthalmol Vis Sci 2009; 50: 1791-800.
43. McLaughlin CW, Peart D, Purves RD, Carre DA, Macknight AD, Civan MM. Effects of HCO3- on cell composition of rabbit ciliary epithelium: a new model for aqueous humor secretion. Invest Ophthalmol Vis Sci 1998; 39: 1631-41.
44. -/HCO3- antiporters of bovine pigmented ciliary epithelial cells. Pflugers Arch 2000; 440: 667-78.
45. Lepple-Wienhues A, Rauch R, Clark AF, Grássmann A, Berweck S, Wiederholt M. Electrophysiological properties of cultured human trabecular meshwork cells. Exp Eye Res 1994; 59: 305-11.
46. Yang Z, Alvarez BV, Chakarova C, et al. Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration. Hum Mol Genet 2005; 14: 255-65.
47. +-HCO3- cotransporter in human corneal endothelial cells. Pflugers Arch 1999; 438: 458-62.
48. O'Connor GR. Calcific band keratopathy. Trans Am Ophthalmol Soc 1972; 70: 58-81.
49. Quigley HA. Glaucoma. Lancet 2011; 377: 1367-77.
50. Wiederholt M, Thieme H, Stumpff F. The regulation of trabecular meshwork and ciliary muscle contractility. Prog Retin Eye Res 2000; 19: 271-95.
51. Wiederholt M, Bielka S, Schweig F, Lütjen-Drecoll E, Lepple-Wienhues A. Regulation of outflow rate and resistance in the perfused anterior segment of the bovine eye. Exp Eye Res 1995; 61: 223-34.
52. 2+ channels in human and bovine trabecular meshwork cells. Exp Eye Res 2000; 70: 285-93.
53. Borgula GA, Karwoski CJ, Steinberg RH. Light-evoked changes in extracellular pH in frog retina. Vision Res 1989; 29: 1069-77.
54. Barnes S, Merchant V, Mahmud F. Modulation of transmission gain by protons at the photoreceptor output synapse. Proc Natl Acad Sci USA 1993; 90: 10081-5.
55. Hare W, WoldeMussie E, Lai R, et al. Efficacy and safety of memantine, an NMDA-Type open-channel blocker, for reduction of retinal injury associated with experimental glaucoma in rat and monkey. Surv Ophthalmol 2001; 45: S284-9.
56. Cursiefen C, Wisse M, Cursiefen S, Jünemann A, Martus P, Korth M. Migraine and tension headache in high-pressure and normal- pressure glaucoma. Am J Ophthalmol 2000; 129: 102-4.
57. Kao L, Kurtz LM, Shao X, et al. Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5). J Biol Chem 2011; 286: 32563-74.
58. Sassani P, Pushkin A, Gross E, et al. Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter. Am J Physiol Cell Physiol 2002; 282: C408-16.
59. +-dependent HCO3- uptake into the rat choroid plexus epithelium is partially DIDS sensitive. Am J Physiol Cell Physiol 2005; 289: C1448-56.