Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP

Antiviral Research

Volumn 117, Issue , 2015, Pages 110-114

  Albulescu, Lucian ^a   Strating, Jeroen R P M ^a   Thibaut, Hendrik Jan ^a   Van Der Linden, Lonneke ^b   Shair, Matthew D ^c   Neyts, Johan ^d   Van Kuppeveld, Frank J M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c HARVARD UNIVERSITY   (United States)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral; Coxsackievirus; Enterovirus; Oxysterol binding protein; Replication

Indexed keywords

ANTINEOPLASTIC AGENT; BINDING PROTEIN; NATURAL PRODUCT; OSW 1; OXYSTEROL; OXYSTEROL BINDING PROTEIN; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; CHOLEST 4 EN 3 ONE; LIGAND; SAPONIN; STEROID RECEPTOR;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENTEROVIRUS REPLICATION; FEMALE; GENE REPLICATION; GENOME; HUMAN; HUMAN CELL; IC50; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS REPLICATION; ANIMAL; CELL LINE; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; ENTEROVIRUS; GROWTH, DEVELOPMENT AND AGING; HELA CELL LINE; METABOLISM; VERO CELL LINE; VIRUS GENOME; VIRUS LOAD;

COXSACKIEVIRUS; ENTEROVIRUS; PICORNAVIRIDAE; RHINOVIRUS; RNA VIRUSES;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CERCOPITHECUS AETHIOPS; CHOLESTENONES; ENTEROVIRUS; GENOME, VIRAL; HELA CELLS; HUMANS; LIGANDS; RECEPTORS, STEROID; SAPONINS; VERO CELLS; VIRAL LOAD; VIRUS REPLICATION;

EID: 84925011918     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2015.02.013     Document Type: Article

References (16)

1. M. Arita Phosphatidylinositol-4 kinase III beta and oxysterol-binding protein accumulate unesterified cholesterol on poliovirus-induced membrane structure Microbiol. Immunol. 58 2014 239 256
2. M. Arita, H. Kojima, T. Nagano, T. Okabe, T. Wakita, and H. Shimizu Oxysterol-binding protein family I is the target of minor enviroxime-like compounds J. Virol. 87 2013 4252 4260
3. M. Arita, Y. Takebe, T. Wakita, and H. Shimizu A bifunctional anti-enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection J. Gen. Virol. 91 2010 2734 2744
4. D.J. Barton, and J.B. Flanegan Synchronous replication of poliovirus RNA: initiation of negative-strand RNA synthesis requires the guanidine-inhibited activity of protein 2C J. Virol. 71 1997 8482 8489
5. G.A. Belov, N. Altan-Bonnet, G. Kovtunovych, C.L. Jackson, J. Lippincott-Schwartz, and E. Ehrenfeld Hijacking components of the cellular secretory pathway for replication of poliovirus RNA J. Virol. 81 2007 558 567
6. G.A. Belov, and F.J. van Kuppeveld (+)RNA viruses rewire cellular pathways to build replication organelles Curr. Opin. Virol. 2 2012 740 747
7. A.W. Burgett, T.B. Poulsen, K. Wangkanont, D.R. Anderson, C. Kikuchi, K. Shimada, S. Okubo, K.C. Fortner, Y. Mimaki, M. Kuroda, J.P. Murphy, D.J. Schwalb, E.C. Petrella, I. Cornella-Taracido, M. Schirle, J.A. Tallarico, and M.D. Shair Natural products reveal cancer cell dependence on oxysterol-binding proteins Nat. Chem. Biol. 7 2011 639 647
8. C. Burkard, M.H. Verheije, O. Wicht, S.I. van Kasteren, F.J. van Kuppeveld, B.L. Haagmans, L. Pelkmans, P.J. Rottier, B.J. Bosch, and C.A. de Haan Coronavirus cell entry occurs through the endo-/lysosomal pathway in a proteolysis-dependent manner PLoS Pathog. 10 2014 e1004502
9. C.A. de Haan, L. van Genne, J.N. Stoop, H. Volders, and P.J. Rottier Coronaviruses as vectors: position dependence of foreign gene expression J. Virol. 77 2003 11312 11323
10. N.Y. Hsu, O. Ilnytska, G. Belov, M. Santiana, Y.H. Chen, P.M. Takvorian, C. Pau, H. van der Schaar, N. Kaushik-Basu, T. Balla, C.E. Cameron, E. Ehrenfeld, F.J. van Kuppeveld, and N. Altan-Bonnet Viral reorganization of the secretory pathway generates distinct organelles for RNA replication Cell 141 2010 799 811
11. K.H. Lanke, H.M. van der Schaar, G.A. Belov, Q. Feng, D. Duijsings, C.L. Jackson, E. Ehrenfeld, and F.J. van Kuppeveld GBF1, a guanine nucleotide exchange factor for Arf, is crucial for coxsackievirus B3 RNA replication J. Virol. 83 2009 11940 11949
12. Pascal S. Roulin, M. Lötzerich, F. Torta, Lukas B. Tanner, Frank J.M. van Kuppeveld, Markus R. Wenk, and Urs F. Greber Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the er-golgi interface Cell Host Microbe 16 2014 677 690
13. H.M. van der Schaar, P. Leyssen, H.J. Thibaut, A. de Palma, L. van der Linden, K.H. Lanke, C. Lacroix, E. Verbeken, K. Conrath, A.M. Macleod, D.R. Mitchell, N.J. Palmer, H. van de Poel, M. Andrews, J. Neyts, and F.J. van Kuppeveld A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIbeta Antimicrob. Agents Chemother. 57 2013 4971 4981
14. H.M. van der Schaar, L. van der Linden, K.H. Lanke, J.R. Strating, G. Purstinger, E. de Vries, C.A. de Haan, J. Neyts, and F.J. van Kuppeveld Coxsackievirus mutants that can bypass host factor PI4KIIIbeta and the need for high levels of PI4P lipids for replication Cell Res. 22 2012 1576 1592
15. H. Wang, J.W. Perry, A.S. Lauring, P. Neddermann, R. De Francesco, and A.W. Tai Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking Gastroenterology 2014
16. E. Wessels, D. Duijsings, R.A. Notebaart, W.J. Melchers, and F.J. van Kuppeveld A proline-rich region in the coxsackievirus 3A protein is required for the protein to inhibit endoplasmic reticulum-to-golgi transport J. Virol. 79 2005 5163 5173