Drug development from natural resource: a systematic approach

Mini-Reviews in Medicinal Chemistry

Volumn 15, Issue 1, 2015, Pages 52-57

  Sharma, S B ^a   Gupta, Richa ^a  

^a UNIVERSITY COLLEGE OF MEDICAL SCIENCES   (India)

Author keywords

Bioassay guided fractionation; Characterization; Limitations; Mechanism of action; Natural source; Structurefunction relation

Indexed keywords

GLUCOSE TRANSPORTER 4; NATURAL PRODUCT; PLANT EXTRACT; BIOLOGICAL PRODUCT;

ARTICLE; AWARENESS; BIOASSAY; BIOLOGICAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; COMBINATORIAL CHEMISTRY; DISTILLATION; DRUG ACTIVITY; DRUG DEVELOPMENT; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MECHANISM; DRUG PURIFICATION; DRUG SCREENING; EXTRACTION; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; MASS SPECTROMETRY; MEDICINAL PLANT; NEOPLASM; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PERCOLATION; PHYTOCHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; SEQUENTIAL SOLVENT EXTRACTION; SOLVENT EXTRACTION; SOXHLET EXTRACTION; X RAY ANALYSIS; X RAY CRYSTALLOGRAPHY; ANIMAL; CHEMISTRY; HUMAN; ISOLATION AND PURIFICATION;

ANIMALS; BIOLOGICAL PRODUCTS; DRUG DISCOVERY; HUMANS; PLANT EXTRACTS; PLANTS, MEDICINAL;

EID: 84924952962     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/138955751501150224160518     Document Type: Article

References (26)

1. Grover, J. K.; Yadav, S.; Vats, V. Medicinal Plants of India with Anti-Diabetic Potential. J. Ethnopharmacol., 2002, 81, 81-100.
2. Scartezzini, P.; Speroni, E. Review on Some Plants of Indian Traditional Medicine with Antioxidant Activity. J. Ethnopharmacology, 2000, 71, 23-43.
3. Sharma, S.B.; Nasir, A.; Prabhu, K.M.; Murthy, P.S. Antihyperglycemic Effect of the Fruit- Pulp of Eugenia Jambolana in Experimental Diabetes Mellitus. J. Ethnopharmacol., 2006, 104, 367-373.
4. Gupta, S.; Sharma, S.B.; Prabhu, K.M. Ameliorative Effect of Cassia Auriculata L. Leaf Extract on Glycemic Control and Atherogenic Lipid Status in Alloxan-Induced Diabetic Rabbits. Indian J. Exp. Biol., 2009, 47, 974-980.
5. Harinantenaina, L.; Tanaka, M.; Takaoka, S.; Oda, M.; Mogami, O.; Uchida, M.; Asakawa, Y. Momordica Charantia Constituents and Antidiabetic Screening of the Isolated Major Compounds. Chem. Pharm. Bull. (Tokyo), 2006, 54, 1017-1021.
6. Sugihara, Y.; Nojima, H.; Matsuda, H.; Murakami, T.; Yoshikawa, M.; Kimura, I. Antihyperglycemic Effects of Gymnemic Acid IV, a Compound Derived from Gymnema Sylvestre Leaves in Streptozotocin-Diabetic Mice. J. Asian Nat. Prod. Res., 2000, 2, 321-327.
7. Sharma, S. B.; Rajpoot, R.; Nasir, A.; Prabhu, K. M.; Murthy, P. S. Ameliorative Effect of Active Principle Isolated from Seeds of Eugenia Jambolana on Carbohydrate Metabolism in Experimental Diabetes. Evid. Based. Complement. Alternat. Med., 2009, doi:10.1093/ecamnep233.
8. Hemalatha, T.; Pulavendran, S.; Balachandran, C.; Manohar, B. M.; Puvanakrishnan, R. Arjunolic Acid: A Novel Phytomedicine with Multifunctional Therapeutic Applications. Indian J. Exp. Biol., 2010, 48, 238-247.
9. Langcake, P. The Production of Resveratrol by Vitis Vinifera and Other Members of the Vitaceae as a Response to Infection or Injury. Physiologial Plant Pathology, 1976, 9, 77-86.
10. Dixon, R.A.; Ferreira, D. Genistein. Phytochemistry, 2002, 60, 205-211.
11. Rao, K.V. Taxol and Related Taxanes. I. Taxanes of Taxus Brevifolia Bark. Pharm. Res. 1993, 10, 521-524.
12. Noble, R.L. The Discovery of the Vinca Alkaloids-- Chemotherapeutic Agents against Cancer. Biochem. Cell Biol., 1990, 68, 1344-1351.
13. Richardson, P.M.; Harborne, J.B. In Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis, 2nd ed; Vol. 42, Routledge, Chapman & Hall, New York, Brittonia, 1990, 115.
14. Shoeb, M.; Celik, S.; Jaspars, M.; Kumarasamy, Y.; MacManus, S. M.; Nahar, L.; Thoo-Lin, P. K.; Sarker, S. D. Isolation, Structure Elucidation and Bioactivity of Schischkiniin, a Unique Indole Alkaloid from the Seeds of Centaurea Schischkinii. Tetrahedron2005, 61, 9001-9006.
15. Latif, Z.; Sarker, S. D. Isolation of Natural Products by Preparative High Performance Liquid Chromatography (prep-HPLC). In Methods in Biotechnology, Natural Products Isolation, 2nd Ed. Sarker, S.D.; Latif, Z.; Gray, A.1., Eds. Humana Press Inc.: Totowa (New Jersey), 2005, 20, 213-232.
16. Starmans, D.A.J.; Nijhuis, H.H. Extraction of Secondary Metabolites from Plant Material: A Review. Trends Food Sci. Technol. 1996, 7, 191-197.
17. Balunas, M. J.; Kinghorn, A. D. Drug Discovery from Medicinal Plants. In Life Sciences, 2005, 78, 431-441.
18. Itokawa, H.; Morris-Natschke, S. L.; Akiyama, T.; Lee, K.-H. Plant-Derived Natural Product Research Aimed at New Drug Discovery. J. Nat. Med., 2008, 62, 263-280.
19. Weller, M.G. A Unifying Review of Bioassay-Guided Fractionation, Effect-Directed Analysis and Related Techniques. Sensors, 2012, 12, 9181-9209.
20. Dias, D. A.; Urban, S.; Roessner, U. A Historical Overview of Natural Products in Drug Discovery. Metabolites, 2012, 2, 303-336.
21. Marston, A.; Hostettmann, K. Modern Separation Methods. Natural Product Reports, 1991, 8, 391.
22. Latif, Z. Isolation by Preparative High-Performance liquid Chromatography. In Methods in Biotechnology, Natural Products Isolation, 2nd ed. Sarker, S.D.; Latif, Z.; Gray, A.1., Eds. Humana Press Inc.: Totowa (New Jersey), 2005, 20, 213-232.
23. L. Huber & S. A. George. Diode Array Detection in HPLC. J. Liq. Chromatogr. 1994, 17, 4057-4058.
24. Niessen, W. M. State-of-the-Art in Liquid Chromatography–mass Spectrometry. J. Chromatogr. A, 1999, 856, 179-197.
25. Spraul, M.; Hofmann, M.; Dvortsak, P.; Nicholson, J. K.; Wilson, I. D. High-Performance Liquid Chromatography Coupled to High- Field Proton Nuclear Magnetic Resonance Spectroscopy: Application to the Urinary Metabolites of Ibuprofen. Anal. Chem. 1993, 65, 327-330.
26. Wolfender, J.-L.; Rodriguez, S.; Hostettmann, K. Liquid Chromatography Coupled to Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy for the Screening of Plant Constituents. J. Chromatogr. A, 1998, 794, 299-316.