Arjunolic acid: A novel phytomedicine with multifunctional therapeutic applications

Indian Journal of Experimental Biology

Volumn 48, Issue 3, 2010, Pages 237-248

  Hemalatha, Thiagarajan ^a   Pulavendran, Sivasami ^a   Balachandran, Chidambaram ^b   Manohar, Bhakthavatsalam Murali ^b   Puvanakrishnan, Rengarajulu ^a  

^a CENTRAL LEATHER RESEARCH INSTITUTE   (India)

^b MADRAS VETERINARY COLLEGE   (India)

Author keywords

Antioxidant; Arjunolic acid; Cardioprotectant; Free radical scavenger; Terminalia arjuna

Indexed keywords

COMBRETUM; LEANDRA; TERMINALIA; TERMINALIA ARJUNA;

ANTIDIABETIC AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ARJUNOLIC ACID; CARDIOTONIC AGENT; PLANT EXTRACT; TRITERPENE;

ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; REVIEW;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; CARDIOTONIC AGENTS; HUMANS; HYPOGLYCEMIC AGENTS; MOLECULAR STRUCTURE; PLANT EXTRACTS; TRITERPENES;

EID: 77954255404     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Vaidya A B, Terminalia arjuna in cardiovascular therapy, J Assoc Physic India, 42 (1994) 281.
2. Nandkarni A K, Terminalia arjuna, in Indian Materia Medica edited by A K Nandkarni and K M Nandkarni (Popular Prakashan Private Limited, Mumbai, India) 1976, 1199.
3. Kumar D S & Prabhakar Y S, On the ethnomedical significance of the arjun tree, Terminalia arjuna (Roxb.) Wight & Arnot, JEthnopharmacol, 20 (1987)173.
4. Chander R, Singh K, Khanna A K, Kaul S M, Puri A, Saxena R, Bhatia G, Rizvi F & Rastogi A K, Antidyslipidemic and antioxidant activities of different fractions of Terminalia arjuna stem bark, Indian J Clin Biochem, 19 (2004) 141.
5. Haider S, Bharal N, Mediratta P K, Kaur I & Sharma K K, Anti-inflammatory, immunomodulatory and antinociceptive activity of Terminalia arjuna Roxb bark powder in mice and rats, Indian J Exp Biol, 46 (2009) 577.
6. Anonymous, Monograph: Terminalia arjuna, Altern Med Rev, 4(1999)436.
7. King F E, King T J & Ross J M, The constitution of arjunolic acid, a triterpene from Terminalia arjuna, J Chem Soc, 23 (1954) 3995.
8. Diallo B, Vanhaelen M, Vanhaelen-Fastré R, Konoshima T, Kozuka M & Tokuda H, Studies on inhibitors of skin-tumor promotion. Inhibitory effects of triterpenes from Cochlospermum tinctorium on Epstein-Barr virus activation,/Nat Prod, 52(1989)879.
9. Bhakuni R S, Shukla Y N, Tripathi A K, Prajapati V & Kumar S, Insect Growth inhibitor activity of arjunolic acid isolated from Cornus capitata, Phytother Res, 16 (2002) S68.
10. Zhang Q, ElSohly H N, Li X C & Walker L A, A new triterpene from Leandra chaetodon, Planta Med, 69 (2003) 582.
11. Facundo V A, Rios K A, Medeiros C M, Militao J S L T, Miranda ALP, Epifanio R A, Carvalho M P, Andrade A T, Pinto A C & Rezende C M, Arjunolic acid in the ethanolic extract of Combretum leprosum root and its use as a potential multi-functional phytomedicine and drug for neurodegenerative disorders: anti-inflammatory and anticholinesterasic activities, JBraz Chem Soc, 16 (2005)1309.
12. Kim D H, Han K M, Chung I S, Kim D K, Kim S H, Kwon B M, Jeong T S, Park M H, Ahn E M & Baek N I, Triterpenoids from the flower of Campsis grandiflora K. Schum. as human Acyl-CoA: Cholesterol acyltransferase Inhibitors, Arch Pharm Res, 28 (2005) 550.
13. Djoukeng J D, Abou-Mansour E, Tabacchi R, Tapondjou A L, Boud H & Lontsi D, Antibacterial triterpenes from Syzygium guineense (Myrtaceae), J Ethnopharmacol, 101 (2005) 283.
14. Masoko P, Mdee L K, Mampuru L J & Eloff J N, Biological activity of two related triterpenes isolated from Combretum nelsonii (Combretaceae) leaves, Nat Prod Res, 22 (2008)1074.
15. Ratsimamanga A R & Boiteau P, GB Pat, 923414 (CA 59: P10239a) 1963.
16. Xu R, Fazio G C & Matsuda S P T, On the origins of triterpenoid skeletal diversity, Phytochem, 65 (2004) 261.
17. Sindambiwe J B, Calomme M, Geerts S, Pieters L, Vlietinck A J & Van den Berghe D A, Evaluation of biological activities of triterpenoid saponins from Maesa lanceolata, J Nat Prod, 61 (1998)585.
18. Ajees A A & Balakrishna K, Arjunolic acid, Acta Crystallogr, E 58(2002), 682.
19. Manna P, Sinha M & Sil P C, Arsenic-induced oxidative myocardial injury: protective role of arjunolic acid, Arch Toxicol, 82 (2008) 137.
20. Sumitra M, Manikandan P, Kumar D A, Arutselvan N, Balakrishna K, Murali Manohar B & Puvanakrishnan R, Experimental myocardial necrosis in rats: role of arjunolic acid on platelet aggregation, coagulation and antioxidant status. Mol Cell Biochem, 224 (2001) 135.
21. Benowitz N L, Cardiotoxicity in the workplace, Occup Med, 7 (1992)465.
22. Manna P, Sinha M & Sil P C, Protection of arsenic-induced hepatic disorder by arjunolic acid, Basic Clin Pharmacol Toxicol, 101(2007)333.
23. Manna P, Sinha M, Pal P & Sil P C, Arjunolic acid, a triperpenoid saponin, ameliorates arsenic-induced cytotoxicity in hepatocytes, Chem Biol Interact, 170 (2007) 187.
24. Sinha M, Manna P & Sil P C, Protective effect of arjunolic acid against arsenic-induced oxidative stress in mouse brain, J Biochem Mol Toxicol, 22 (2008) 15.
25. Sinha M, Manna P & Sil P C, Arjunolic acid attenuates arsenic-induced nephrotoxicity, Pathophysiology, 15, (2008) 147.
26. Manna P, Sinha M & Sil P C, Protection of arsenic-induced testicular oxidative stress by arjunolic acid, Redox Rep, 13 (2008) 67.
27. World Health Organization, Environmental Health Criteria, (227 Fluorides IPS, Geneva, Switzerland) 2002.
28. Ghosh J, Das J, Manna P & Sil P C, Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway, Toxicol in vitro, 22 (2008)1918.
29. Ghosh J, Das J, Manna P & Sil P C, Acetaminophen induced renal injury via oxidative stress and TNF-alpha production: therapeutic potential of arjunolic acid, Toxicology, 13 (2009) (in press).
30. Ghosh J, Das J, Manna P & Sil P C, Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP) induced liver and hepatocytes injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection, Free Radic Biol Med, (2009) (in press).
31. Ghanekar B G, Ayurveda Rahasyadipika, in Sushruta Samhita with Hindi commentary-Sutra and Nidansthan (Mehar Chand Lachhmandas, Lahore) 1936, 213.
32. Chaudhari M & Mengi S, Evaluation of phytoconstituents of Terminalia arjuna for wound healing activity in rats, Phytother Res, 20 (2006) 799.
33. Brown M S, Dana S E & Goldstein J L, Cholsterol ester formation in cultured human fibroblasts, J Biol Chem, 250 (1975)4025.
34. Coses S, Novak S, Zheng Y, Myers H M, Lear S R, Sande E, Welch C B, Lusis A J, Spancer T A, Krouse B R, Erickson S K & Farese R V, ACAT-2, a second mammalian acyl-CoA: Cholesterol acyltransferase, J Biol Chem, 273 (1998) 26755.
35. Manna P, Sinha M & Sil P C, Protective role of arjunolic acid in response to streptozotocin-induced type-I diabetes via the mitochondrial dependent and independent pathways, Toxicology, 257 (2009) 53.
36. Manna P, Sinha M & Sil P C, Prophylactic role of arjunolic acid in response to streptozotocin mediated diabetic renal injury: Activation of polyol pathway and oxidative stress responsive signaling cascades, Chem Biol Interact, 181 (2009) 297.
37. Floris L L, Peter P A, Reinier H V, Eloy E R, Guy & Chris V W, α-Glucosidase inhibitors for patients with Type 2 diabetes, Diabet Care, 28 (2005) 154.
38. Hou W, Li Y, Zhang Q, Wei X, Peng A, Chen L & Wei Y, Triterpene acids isolated from Lagerstroemia speciosa leaves as alpha-glucosidase inhibitors, Phytother Res, 23 (2009) 614.
39. Prasad M V V, Anbalagan N, Patra A, Veluchamy G & Balakrishna K, Antiallergic and anti-asthmatic activities of the alcoholic extract of Terminalia arjuna and arjunolic acid, Nat Prod Sci, 10 (2004) 240.
40. Summers R, Sigler R, Shelhamer J H & Kaliner M, Effects of infused histamine on asthmatic and normal subjects; Comparison of skin test responses, J Allergy Clin Immunol, 67 (1981)456.
41. Akah P A, Ezike A C, Nwafor S V, Ololiad C O & Enwerem N M, Evaluation of asthmatic property of asystasia gangetic leaf extracts, J Ethnopharmacol, 89 (2003) 25.
42. Diallo B, Vanhaelen-Fastre R, Vanhaelen M, Konoshima T, Takasaki M & Tokuda H, In vivo inhibitory effects of arjunolic acid derivatives on two-stage carcinogenesis in mouse skin, Phytother Res, 9 (2006) 444.
43. Liu M, Katerere D R, Gray AI & Seidel V, Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma, Fitoterapia, 80 (2009) 369.
44. Bag B G, Pramanik S R & Maity G C, Arjunolic acid in molecular recognition: first synthesis and cation binding studies of a novel Arjuna-18-crown-6, Supramol Chem, 17 (2005)297.
45. Bag B G & Dinda S K, Arjunolic acid: A renewable template in supramolecular chemistry and nanoscience, Pure Appl Chem, 79 (2007)2031.
46. Bag B G, Dey PP, Dinda S K, Sheldrick W S & Oppel I M, Simple route for renewable nano-sized arjunolic and Asiatic acids and self-assembly of arjuna-bromolactone, Beilstein J Org Chem, 2 (2008) 24.
47. Bag B G, Dinda S K, Dey P P, Mallia V A & Weiss R G, Self-assembly of esters of arjunolic acid into fibrous networks and the properties of their organogels (dagger), Langmuir, (2009) (in press).