OA phenotypes, rather than disease stage, drive structural progression - identification of structural progressors from 2 phase III randomized clinical studies with symptomatic knee OA

Osteoarthritis and Cartilage

Volumn 23, Issue 4, 2015, Pages 550-558

  Karsdal, M A ^a   Bihlet, A ^a   Byrjalsen, I ^a   Alexandersen, P ^b   Ladel, C ^d   Michaels, M ^d   Andersen, J R ^a   Riis, B J ^a   Kraus, V ^c   Bay Jensen, A C ^a   Christiansen, C ^a  

^a NORDIC BIOSCIENCE A S   (Denmark)

^b CCBR   (Denmark)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Merck Serono GmbH   (Germany)

Author keywords

Biomarker; Clinical; Diagnosis; Osteoarthritis; PhaseIII; Progression

Indexed keywords

SALCATONIN; BONE DENSITY CONSERVATION AGENT; CALCITONIN;

ADULT; AGED; ARTHRALGIA; ARTICLE; ASSESSMENT OF HUMANS; BODY MASS; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE COURSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; FEMALE; HUMAN; JOINT CAVITY; JOINT SPACE NARROWING; JOINT SPACE WIDTH; KELLGREN LAWRENCE GRADE; KNEE; KNEE OSTEOARTHRITIS; KNEE PAIN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTICENTER STUDY; NOCICEPTION; NONLINEAR REGRESSION ANALYSIS; PHASE 3 CLINICAL TRIAL; PHENOTYPE; POST HOC ANALYSIS; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SYMPTOM; TREATMENT DURATION; WESTERN ONTARIO AND MCMASTER UNIVERSITIES OSTEOARTHRITIS INDEX; CLINICAL TRIAL; INCIDENCE; OSTEOARTHRITIS, KNEE; PAIN MEASUREMENT; PATHOPHYSIOLOGY; RADIOGRAPHY; TREATMENT OUTCOME;

AGED; ARTHRALGIA; BODY MASS INDEX; BONE DENSITY CONSERVATION AGENTS; CALCITONIN; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INCIDENCE; KNEE JOINT; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PAIN MEASUREMENT; PHENOTYPE; PROGNOSIS; TREATMENT OUTCOME;

EID: 84924919379     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2014.12.024     Document Type: Article

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