Intraperitoneal and intravenous deliveries are not comparable in terms of drug efficacy and cell distribution in neonatal mice with hypoxia-ischemia

Brain and Development

Volumn 37, Issue 4, 2015, Pages 376-386

  Ohshima, Makiko ^a   Taguchi, Akihiko ^b   Tsuda, Hidetoshi ^a   Sato, Yoshiaki ^c   Yamahara, Kenichi ^a   Harada Shiba, Mariko ^a   Miyazato, Mikiya ^a   Ikeda, Tomoaki ^d   Iida, Hidehiro ^a   Tsuji, Masahiro ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b INSTITUTE OF BIOMEDICAL RESEARCH AND INNOVATION   (Japan)

^c NAGOYA UNIVERSITY HOSPITAL   (Japan)

^d MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell transfusion; Dexamethasone; Intraperitoneal injection; Intravenous injection; Mesenchymal stem cell; MK 801; Mononuclear cell; Neonatal hypoxic ischemic encephalopathy; Primate

Indexed keywords

DEXAMETHASONE; DIZOCILPINE; FLUORODEOXYGLUCOSE F 18; GREEN FLUORESCENT PROTEIN; AMINO ACID RECEPTOR BLOCKING AGENT; DIZOCILPINE MALEATE; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR DISTRIBUTION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DRUG EFFICACY; FEMORAL VEIN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNOHISTOCHEMISTRY; JUVENILE; LIVER; LUNG; MACACA; MESENCHYMAL STEM CELL; MONONUCLEAR CELL; MOUSE; NEUROPROTECTION; NEWBORN; NEWBORN DISEASE; NONHUMAN; PROTEIN EXPRESSION; SPLEEN; THERAPY EFFECT; ANIMAL; BONE MARROW TRANSPLANTATION; BRAIN; CAROTID ARTERY DISEASE; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECTS; HYPOXIA-ISCHEMIA, BRAIN; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LEWIS RAT; MALE; METABOLISM; RANDOMIZATION; TRANSGENIC RAT; TREATMENT OUTCOME;

ANIMALS; ANIMALS, NEWBORN; BONE MARROW TRANSPLANTATION; BRAIN; CAROTID ARTERY DISEASES; DEXAMETHASONE; DISEASE MODELS, ANIMAL; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; FEMORAL VEIN; FLUORODEOXYGLUCOSE F18; HYPOXIA-ISCHEMIA, BRAIN; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; LEUKOCYTES, MONONUCLEAR; MACACA; MALE; MICE; NEUROPROTECTIVE AGENTS; RANDOM ALLOCATION; RATS, INBRED LEW; RATS, TRANSGENIC; TREATMENT OUTCOME;

EID: 84924908576     PISSN: 03877604     EISSN: 18727131     Source Type: Journal    
DOI: 10.1016/j.braindev.2014.06.010     Document Type: Article

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