Inhibition of glycogen synthase kinase-3β attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat

Shock

Volumn 43, Issue 4, 2015, Pages 369-378

  Rocha, Joao ^a   Figueira, Maria Eduardo ^a   Barateiro, Andreia ^a   Fernandes, Adelaide ^a   Brites, Dora ^a   Pinto, Rui ^a   Freitas, Marisa ^b   Fernandes, Eduarda ^b   Mota Filipe, Helder ^a   Sepodes, Bruno ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Acute lung injury; GSK 3 ; Insulin; Ischemia reperfusion; Liver; TDZD 8; Thermal injury

Indexed keywords

(4 BENZYL 2 METHYL 1,2,4 THIADIAZOLIDINE 3,5 DIONE); ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CREATININE; CYTOPROTECTIVE AGENT; GAMMA GLUTAMYLTRANSFERASE; GELATINASE B; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTATE DEHYDROGENASE; METALLOPROTEINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE; CYTOKINE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MMP9 PROTEIN, HUMAN; MMP9 PROTEIN, RAT; THIADIAZOLE DERIVATIVE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL ACTIVATION; CELL PROTECTION; CLINICAL EVALUATION; CONTINUOUS INFUSION; CONTROLLED STUDY; ENZYME INHIBITION; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LACTATE DEHYDROGENASE BLOOD LEVEL; LEUKOCYTE ACTIVATION; LIVER DYSFUNCTION; LIVER ISCHEMIA; LUNG DISEASE; MALE; MULTIPLE ORGAN FAILURE; NEUROMUSCULAR DISEASE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NORMAL HUMAN; ORGAN INJURY; RAT; REPERFUSION INJURY; RESPIRATORY BURST; THERMAL INJURY; TISSUE INJURY; ACUTE LUNG INJURY; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; CELL LINEAGE; CHEMISTRY; HEAT; INFLAMMATION; LIVER; METABOLISM; NEUTROPHIL; OXIDATIVE STRESS; PATHOPHYSIOLOGY; WISTAR RAT;

ACUTE LUNG INJURY; ANIMALS; ASPARTATE AMINOTRANSFERASES; CELL LINEAGE; CYTOKINES; GLYCOGEN SYNTHASE KINASE 3; HOT TEMPERATURE; HUMANS; INFLAMMATION; INSULIN; LIVER; MALE; MATRIX METALLOPROTEINASE 9; NEUTROPHILS; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; REPERFUSION INJURY; THIADIAZOLES;

EID: 84924905290     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000298     Document Type: Article

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