Evidence for the formation of an enamine species during aldol and Michael-type addition reactions promiscuously catalyzed by 4-oxalocrotonate tautomerase

ChemBioChem

Volumn 16, Issue 5, 2015, Pages 738-741

  Poddar, Harshwardhan ^a   Rahimi, Mehran ^a   Geertsema, Edzard M ^a   Thunnissen, Andy Mark W H ^b   Poelarends, Gerrit J ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

4 oxalocrotonate tautomerase; aldol reaction; enamine formation; H D exchange; Michael addition

Indexed keywords

4 OXALOCROTONATE TAUTOMERASE; ACETALDEHYDE; BENZALDEHYDE; CINNAMALDEHYDE; ENAMINE; ISOMERASE; UNCLASSIFIED DRUG; 4-OXALOCROTONATE TAUTOMERASE; ALDEHYDE; AMINE;

ALDOL REACTION; ARTICLE; CATALYST; CRYSTAL STRUCTURE; ELECTROPHILICITY; MICHAEL ADDITION; NUCLEOPHILICITY; PH; PRIORITY JOURNAL; PROTON TRANSPORT; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM;

ALDEHYDES; AMINES; BIOCATALYSIS; CRYSTALLOGRAPHY, X-RAY; ISOMERASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

EID: 84924903145     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201402687     Document Type: Article

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