C5aR is frequently expressed in metastatic renal cell carcinoma and plays a crucial role in cell invasion via the ERK and PI3 kinase pathways

Oncology Reports

Volumn 33, Issue 4, 2015, Pages 1844-1850

  Maeda, Yoshihiro ^a   Kawano, Yoshiaki ^a   Wada, Yoshihiro ^a   Yatsuda, Junji ^a   Motoshima, Takanobu ^a   Murakami, Yoji ^a   Kikuchi, Ken ^b   Imamura, Takahisa ^a   Eto, Masatoshi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

C5a receptor; Neoplasm invasiveness; Renal cell carcinoma; Signal transduction

Indexed keywords

ACTIN; COMPLEMENT COMPONENT C5A RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; C5AR1 PROTEIN, HUMAN; C5AR1 PROTEIN, MOUSE; COMPLEMENT COMPONENT C5A; HYBRID PROTEIN; RECOMBINANT PROTEIN; TUMOR PROTEIN;

ADULT; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER MORPHOLOGY; CANCER PREVENTION; CARCINOGENESIS; CELL PROTECTION; CELL STRUCTURE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; KIDNEY METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR INVASION; AGED; ANOIKIS; CYTOSKELETON; DRUG EFFECTS; GENETICS; KIDNEY CARCINOMA; KIDNEY TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; ULTRASTRUCTURE;

ACTINS; AGED; ANOIKIS; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; COMPLEMENT C5A; CYTOSKELETON; FEMALE; HUMANS; KIDNEY NEOPLASMS; MALE; MAP KINASE SIGNALING SYSTEM; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTOR, ANAPHYLATOXIN C5A; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 84924874096     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.3800     Document Type: Article

References (28)

1. Zisman A, Pantuck AJ, Wieder J, et al: Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma. J Clin Oncol 20: 4559-4566, 2002.
2. Wada Y, Takahashi W, Kawano Y and Eto M: Current status of pharmacotherapy against metastatic renal cell carcinoma in Japan. Int J Urol 19: 284-295, 2012.
3. Müller A, Homey B, Soto H, et al: Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50-56, 2001.
4. Guo RF and Ward PA: Role of C5a in inflammatory responses. Annu Rev Immunol 23: 821-852, 2005.
5. Cao Q, McIsaac SM and Stadnyk AW : Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway. Am J Physiol Cell Physiol 302: C1731?C1740, 2012.
6. Kwan WH, van der Touw W, Paz-Artal E, Li MO and Heeger PS: Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells. J Exp Med 210: 257-268, 2013.
7. Chiou WF, Tsai HR, Yang LM and Tsai WJ: C5a differentially stimulates the ERK1/2 and p38 MAPK phosphorylation through independent signaling pathways to induced chemotactic migration in RAW 264.7 macrophages. Int Immunopharmacol 4: 1329-1341, 2004.
8. Tsai HR, Yang LM, Tsai WJ and Chiou WF: Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration. Eur J Pharmacol 498: 45-52, 2004.
9. Nitta H, Wada Y, Kawano Y, et al: Enhancement of human cancer cell motility and invasiveness by anaphylatoxin C5a via aberrantly expressed C5a receptor (CD88). Clin Cancer Res 19: 2004-2013, 2013.
10. Kawano Y, Diez S, Uysal-Onganer P, Darrington RS, Waxman J and Kypta RM: Secreted frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer. Br J Cancer 100: 1165-1174, 2009.
11. Shvarts O, Janzen N, Lam JS, et al: RENCA/carbonic anhydrase?IX: a murine model of a carbonic anhydrase? IX?expressing renal cell carcinoma. Urology 68: 1132-1138, 2006.
12. Berezovskaya O, Schimmer AD, Glinskii AB, et al: Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells. Cancer Res 65: 2378-2386, 2005.
13. Eto M, Kamiryo Y, Takeuchi A, et al: Posttransplant administration of cyclophosphamide and donor lymphocyte infusion induces potent antitumor immunity to solid tumor. Clin Cancer Res 14: 2833-2840, 2008.
14. Frisch SM and Screaton RA: Anoikis mechanisms. Curr Opin Cell Biol 13: 555-562, 2001.
15. Banks P, Barker MD and Burton DR: Recruitment of actin to the cytoskeletons of human monocyte-like cells activated by complement fragment C5a. Is protein kinase C involved? Biochem J 252: 765-769, 1988.
16. Monk PN and Banks P: Evidence for the involvement of multiple signalling pathways in C5a-induced actin polymerization and nucleation in human monocyte-like cells. J Mol Endocrinol 6: 241-247, 1991.
17. Li K, Fazekasova H, Wang N, et al: Functional modulation of human monocytes derived DCs by anaphylatoxins C3a and C5a. Immunobiology 217: 65-73, 2012.
18. Bosmann M, Patel VR, Russkamp NF, et al: MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway. FAS EB J 25: 4222-4232, 2011.
19. Don MJ, Liao JF, Lin LY and Chiou WF: Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of the PI3K signaling pathway. Br J Pharmacol 151: 638-646, 2007.
20. Mendoza MC, Er EE, Zhang W, et al: ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex. Mol Cell 41: 661-671, 2011.
21. Posern G, Saffrich R, Ansorge W and Feller SM: Rapid lamellipodia formation in nerve growth factor-stimulated PC12 cells is dependent on Rac and PI3K activity. J Cell Physiol 183: 416-424, 2000.
22. Angelotti ML, Ronconi E, Ballerini L, et al: Characterization of renal progenitors committed toward tubular lineage and their regenerative potential in renal tubular injury. Stem Cells 30: 1714-1725, 2012.
23. Hanahan D and Weinberg RA: Hallmarks of cancer: the next generation. Cell 144: 646-674, 2011.
24. Hall A: Rho GTPases and the actin cytoskeleton. Science 279: 509-514, 1998.
25. Li Z, Hannigan M, Mo Z, et al: Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell 114: 215-227, 2003.
26. Campbell L, Nuttall R, Griffiths D and Gumbleton M: Activated extracellular signal-regulated kinase is an independent prognostic factor in clinically confined renal cell carcinoma. Cancer 115: 3457-3467, 2009.
27. Horiguchi A, Oya M, Uchida A, Marumo K and Murai M: Elevated Akt activation and its impact on clinicopathological features of renal cell carcinoma. J Urol 169: 710-713, 2003.
28. Figlin RA, Kaufmann I and Brechbiel J: Targeting PI3K and mTORC2 in metastatic renal cell carcinoma: new strategies for overcoming resistance to VEGFR and mTO RC1 inhibitors. Int J Cancer 133: 788-796, 2013.