Applying the retro-enantio approach to obtain a peptide capable of overcoming the blood-brain barrier

Angewandte Chemie - International Edition

Volumn 54, Issue 13, 2015, Pages 3967-3972

  Prades, Roger ^a   Oller Salvia, Benjamí ^a   Schwarzmaier, Susanne M ^b,c   Selva, Javier ^d   Moros, María ^e   Balbi, Matilde ^b,c   Grazú, Valeria ^e   De La Fuente, Jesus M ^e   Egea, Gustavo ^d   Plesnila, Nikolaus ^b,c,f   Teixidõ, Meritxell ^a   Giralt, Ernest ^a,d  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d UNIVERSITY OF BARCELONA   (Spain)

^e Instituto de Nanociencia y Materiales de Aragón   (Spain)

^f Germany 3 Munich Cluster for Systems Neurology   (Germany)

Author keywords

blood brain barrier; enantioselectivity; membranes; peptides; receptors

Indexed keywords

BLOOD; ENANTIOSELECTIVITY; MEMBRANES;

BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEMS; ENANTIO; RECEPTORS; TRANSFERRIN RECEPTORS;

PEPTIDES;

CENTRAL NERVOUS SYSTEM AGENTS; PEPTIDE; PEPTIDE HYDROLASE; TRANSFERRIN RECEPTOR;

ANIMAL; BLOOD BRAIN BARRIER; BOVINE; CHEMISTRY; COCULTURE; DRUG EFFECTS; ENDOTHELIUM CELL; METABOLISM; MOUSE; PERMEABILITY; RAT; STEREOISOMERISM; SYNTHESIS; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CATTLE; CENTRAL NERVOUS SYSTEM AGENTS; COCULTURE TECHNIQUES; ENDOTHELIAL CELLS; MICE; PEPTIDE HYDROLASES; PEPTIDES; PERMEABILITY; RATS; RECEPTORS, TRANSFERRIN; STEREOISOMERISM;

EID: 84924869467     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201411408     Document Type: Article

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