Lipopolysaccharide binding protein, interleukin-10, interleukin-6 and C-reactive protein blood levels in acute ischemic stroke patients with post-stroke infection

Journal of Neuroinflammation

Volumn 12, Issue 1, 2015, Pages

  Worthmann, Hans ^a   Tryc, Anita B ^a   Dirks, Meike ^a   Schuppner, Ramona ^a   Brand, Korbinian ^a   Klawonn, Frank ^b,c   Lichtinghagen, Ralf ^a   Weissenborn, Karin ^a,d  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF EXETER   (United Kingdom)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^d CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

Author keywords

C reactive protein; infection; inflammation; interleukin 10; Interleukin 6; lipopolysaccharide binding protein (LBP); stroke

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE BINDING PROTEIN; PROTEIN S100B; ACUTE PHASE PROTEIN; CARRIER PROTEIN; LIPOPOLYSACCHARIDE-BINDING PROTEIN; MEMBRANE PROTEIN;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; BLOOD SAMPLING; BRAIN DAMAGE; BRAIN ISCHEMIA; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE SEVERITY; FEMALE; HIGH RISK PATIENT; HUMAN; INFECTION; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; RISK FACTOR; STROKE PATIENT; TRANSIENT ISCHEMIC ATTACK; BLOOD; COMPLICATION; METABOLISM; MIDDLE AGED; NEUROIMAGING; SEVERITY OF ILLNESS INDEX; STATISTICS; TIME FACTOR; VERY ELDERLY;

ACUTE-PHASE PROTEINS; AGED; AGED, 80 AND OVER; C-REACTIVE PROTEIN; CARRIER PROTEINS; COHORT STUDIES; FEMALE; HUMANS; INFECTION; INTERLEUKIN-10; INTERLEUKIN-6; ISCHEMIC ATTACK, TRANSIENT; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NEUROIMAGING; ROC CURVE; SEVERITY OF ILLNESS INDEX; STATISTICS AS TOPIC; TIME FACTORS;

EID: 84924866874     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-014-0231-2     Document Type: Article

References (29)

1. Aslanyan S, Weir CJ, Diener HC, Kaste M, Lees KR. GAIN International Steering Committee and Investigators. Pneumonia and urinary tract infection after acute ischaemic stroke: a tertiary analysis of the GAIN International trial. Eur J Neurol. 2004;11:49-53.
2. Prass K, Meisel C, Höflich C, Braun J, Halle E, Wolf T, et al. Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med. 2003;198:725-36.
3. Chamorro A, Urra X, Planas AM. Infection after acute ischemic stroke: a manifestation of brain-induced immunodepression. Stroke. 2007;38:1097-103.
4. Worthmann H, Tryc AB, Deb M, Goldbecker A, Ma YT, Tountopoulou A, et al. Linking infection and inflammation in acute ischemic stroke. Ann N Y Acad Sci. 2010;1207:116-22. Review.
5. Chamorro Á, Meisel A, Planas AM, Urra X, van de Beek D, Veltkamp R. The immunology of acute stroke. Nat Rev Neurol. 2012;8:401-10. doi: 10.1038/nrneurol.2012.98.
6. Chamorro A, Amaro S, Vargas M, Obach V, Cervera A, Torres F, et al. Interleukin 10, monocytes and increased risk of early infection in ischaemic stroke. J Neurol Neurosurg Psychiatry. 2006;2006:1279-81.
7. Urra X, Cervera A, Obach V, Climent N, Planas AM, Chamorro A. Monocytes are major players in the prognosis and risk of infection after acute stroke. Stroke. 2009;40:1262-8.
8. Emsley HC, Smith CJ, Gavin CM, Georgiou RF, Vail A, Barberan EM, et al. An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis. J Neuroimmunol. 2003;139:93-101.
9. Villar J, Maca-Meyer N, Pérez-Méndez L, Flores C. Bench-to-bedside review: understanding genetic predisposition to sepsis. Crit Care. 2004;8:180-9.
10. Wartenberg KE, Stoll A, Funk A, Meyer A, Schmidt JM, Berrouschot J. Infection after acute ischemic stroke: risk factors, biomarkers, and outcome. Stroke Res Treat. 2011;2011:830614.
11. Westendorp WF, Vermeij JD, Vermeij F, Den Hertog HM, Dippel DW, van de Beek D, et al. Antibiotic therapy for preventing infections in patients with acute stroke. Cochrane Database Syst Rev. 2012;1:CD008530.
12. Worthmann H, Tryc AB, Goldbecker A, Ma YT, Tountopoulou A, Hahn A, et al. The temporal profile of inflammatory markers and mediators in blood after acute ischemic stroke differs depending on stroke outcome. Cerebrovasc Dis. 2010;30:85-92.
13. Adams Jr HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24:35-41.
14. Robin X, Turck N, Hainard A, Tiberti AN, Lisacek F, Sanchez J-C, et al. pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics. 2011;12:77.
15. Lambertsen KL, Biber K, Finsen B. Inflammatory cytokines in experimental and human stroke. J Cereb Blood Flow Metab. 2012;32:1677-98.
16. O'Farrell AM, Liu Y, Moore KW, Mui AL. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J. 1998;17:1006-18.
17. Kammersgaard LP, Jørgensen HS, Rungby JA, Reith J, Nakayama H, Weber UJ, et al. Admission body temperature predicts long-term mortality after acute stroke: the Copenhagen Stroke Study. Stroke. 2002;33:1759-62.
18. Leonardi-Bee J, Bath PM, Phillips SJ, Sandercock PA. IST Collaborative Group. Blood pressure and clinical outcomes in the International Stroke Trial. Stroke. 2002;33:1315-20.
19. Rocco A, Pasquini M, Cecconi E, Sirimarco G, Ricciardi MC, Vicenzini E, et al. Monitoring after the acute stage of stroke: a prospective study. Stroke. 2007;38:1225-8.
20. Schwarz S, Al-Shajlawi F, Sick C, Meairs S, Hennerici MG. Effects of prophylactic antibiotic therapy with mezlocillin plus sulbactam on the incidence and height of fever after severe acute ischemic stroke: the Mannheim infection in stroke study (MISS). Stroke. 2008;39:1220-7.
21. Harms H, Prass K, Meisel C, Klehmet J, Rogge W, Drenckhahn C, et al. Preventive antibacterial therapy in acute ischemic stroke: a randomized controlled trial. PLoS One. 2008;3:e2158.
22. Chamorro A, Horcajada JP, Obach V, Vargas M, Revilla M, Torres F, et al. The Early Systemic Prophylaxis of Infection After Stroke study: a randomized clinical trial. Stroke. 2005;36:1495-500.
23. Lampl Y, Boaz M, Gilad R, Lorberboym M, Dabby R, Rapoport A, et al. Minocycline treatment in acute stroke: an open-label, evaluator-blinded study. Neurology. 2007;69:1404-10.
24. Padma Srivastava MV, Bhasin A, Bhatia R, Garg A, Gaikwad S, Prasad K, et al. Efficacy of minocycline in acute ischemic stroke: a single-blinded, placebo-controlled trial. Neurol India. 2012;60:23-8.
25. Kwan J, Horsfield G, Bryant T, Gawne-Cain M, Durward G, Byrne CD, et al. IL-6 is a predictive biomarker for stroke associated infection and future mortality in the elderly after an ischemic stroke. Exp Gerontol. 2013;48:960-5.
26. Fluri F, Morgenthaler NG, Mueller B, Christ-Crain M, Katan M. Copeptin, procalcitonin and routine inflammatory markers-predictors of infection after stroke. PLoS One. 2012;7:e48309.
27. Klehmet J, Harms H, Richter M, Prass K, Volk HD, Dirnagl U, et al. Stroke-induced immunodepression and post-stroke infections: lessons from the preventive antibacterial therapy in stroke trial. Neuroscience. 2009;158:1184-93.
28. Walter U, Knoblich R, Steinhagen V, Donat M, Benecke R, Kloth A. Predictors of pneumonia in acute stroke patients admitted to a neurological intensive care unit. J Neurol. 2007;254:1323-9.
29. Sellars C, Bowie L, Bagg J, Sweeney MP, Miller H, Tilston J, et al. Risk factors for chest infection in acute stroke: a prospective cohort study. Stroke. 2007;38:2284-91.