CSF miR-16 is decreased in major depression patients and its neutralization in rats induces depression-like behaviors via a serotonin transmitter system

Journal of Affective Disorders

Volumn 178, Issue , 2015, Pages 25-31

  Song, Ming Fen ^a   Dong, Jie Zheng ^a   Wang, Yu Wen ^a   He, Jun ^a   Ju, Xuan ^a   Zhang, Long ^a   Zhang, Yong Hua ^a   Shi, Jian Fei ^a   Lv, Ya Ying ^a  

^a HANGZHOU SEVENTH PEOPLE S HOSPITAL   (China)

Author keywords

Cerebrospinal fluid; Hamilton score; Major depressive disorder miR 16; Serotonin; Serotonin transporter

Indexed keywords

ANTAGOMIR; MICRORNA 16; SEROTONIN; SEROTONIN TRANSPORTER; ANTAGOMIR-16; MICRORNA; MIRN16 MICRORNA, HUMAN; OLIGONUCLEOTIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FORCED SWIM TEST; HAMILTON DEPRESSION RATING SCALE; HUMAN; MAJOR DEPRESSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SEROTONIN BLOOD LEVEL; SEROTONIN BRAIN LEVEL; SEROTONINERGIC SYSTEM; SEROTONINERGIC TRANSMISSION; SUCROSE PREFERENCE TEST; WESTERN BLOTTING; ADOLESCENT; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; BLOOD; CASE CONTROL STUDY; DEPRESSION; DRUG EFFECTS; GENETICS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; MIDDLE AGED; PSYCHOLOGY; RAPHE NUCLEUS; SYNAPTIC TRANSMISSION; YOUNG ADULT;

ADOLESCENT; ADULT; ANIMALS; BEHAVIOR, ANIMAL; CASE-CONTROL STUDIES; DEPRESSION; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; INJECTIONS, INTRAVENTRICULAR; MALE; MICRORNAS; MIDDLE AGED; OLIGONUCLEOTIDES; RAPHE NUCLEI; RATS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SYNAPTIC TRANSMISSION; YOUNG ADULT;

EID: 84924813291     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2015.02.022     Document Type: Article

References (33)

1. M. Bai, X. Zhu, Y. Zhang, S. Zhang, L. Zhang, L. Xue, J. Yi, S. Yao, and X. Zhang Abnormal hippocampal BDNF and miR-16 expression is associated with depression-like behaviors induced by stress during early life PLoS One 7 2012 e46921
2. X.M. Bao, and S.Y. Shu The Rat Brain in Stereotaxic Coordinates 1991 People's Medical Publishing House Beijing
3. A. Baudry, S. Mouillet-Richard, B. Schneider, J.M. Launay, and O. Kellermann miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants Science 329 2010 1537 1541
4. L. Bocchio-Chiavetto, E. Maffioletti, P. Bettinsoli, C. Giovannini, S. Bignotti, D. Tardito, D. Corrada, L. Milanesi, and M. Gennarelli Blood microRNA changes in depressed patients during antidepressant treatment Eur. Neuropsychopharmacol. 23 2013 602 611
5. Y. Dwivedi Evidence demonstrating role of microRNAs in the etiopathology of major depression J. Chem. Neuroanat. 42 2011 142 156
6. G. Engstrom, C. Alling, K. Blennow, G. Regnell, and L. Traskman-Bendz Reduced cerebrospinal HVA concentrations and HVA/5-HIAA ratios in suicide attempters. Monoamine metabolites in 120 suicide attempters and 47 controls Eur. Neuropsychopharmacol. 9 1999 399 405
7. A. Etheridge, I. Lee, L. Hood, D. Galas, and K. Wang Extracellular microRNA: a new source of biomarkers Mutat. Res. 717 2011 85 90
8. S.K. Fineberg, K.S. Kosik, and B.L. Davidson MicroRNAs potentiate neural development Neuron 64 2009 303 309
9. H.Q. Gao, H.Y. Zhu, Y.Q. Zhang, and L.X. Wang Reduction of cerebrospinal fluid and plasma serotonin in patients with post-stroke depression: a preliminary report Clin. Investig. Med. 31 2008 E351 E356
10. T.Y. Ha MicroRNAs in human diseases: from autoimmune diseases to skin, psychiatric and neurodegenerative diseases Immune Netw. 11 2011 227 244
11. J.R. Hibbeln, M. Linnoila, J.C. Umhau, R. Rawlings, D.T. George, and N. Salem Jr. Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics Biol. Psychiatry 44 1998 235 242
12. C. Hou, F. Jia, Y. Liu, and L. Li CSF serotonin, 5-hydroxyindolacetic acid and neuropeptide Y levels in severe major depressive disorder Brain Res. 1095 2006 154 158
13. C. Huff, N. Bhide, A. Schroering, B.K. Yamamoto, and G.A. Gudelsky Effect of repeated exposure to MDMA on the function of the 5-HT transporter as assessed by synaptosomal 5-HT uptake Brain Res. Bull. 91 2013 52 57
14. O. Issler, S. Haramati, E.D. Paul, H. Maeno, I. Navon, R. Zwang, S. Gil, H.S. Mayberg, B.W. Dunlop, A. Menke, R. Awatramani, E.B. Binder, E.S. Deneris, C.A. Lowry, and A. Chen MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity Neuron 83 2014 344 360
15. J.P. Jacobsen, I.O. Medvedev, and M.G. Caron The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse Philos. Trans. R. Soc. Lond. B Biol. Sci. 367 2012 2444 2459
16. E. Jane Costello, A. Erkanli A Fau - Angold, and A. Angold Is there an epidemic of child or adolescent depression? J. Child Psychol. Psychiatry 47 2006 1263 1271
17. I. Kishida, E. Aklillu, C. Kawanishi, L. Bertilsson, and H. Agren Monoamine metabolites level in CSF is related to the 5-HTT gene polymorphism in treatment-resistant depression Neuropsychopharmacol.: Off. Publ. Am. Coll. Neuropsychopharmacol. 32 2007 2143 2151
18. J. Krol, V. Busskamp, I. Markiewicz, M.B. Stadler, S. Ribi, J. Richter, J. Duebel, S. Bicker, H.J. Fehling, D. Schubeler, T.G. Oertner, G. Schratt, M. Bibel, B. Roska, and W. Filipowicz Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs Cell 141 2010 618 631
19. A.W. Kuss, and W. Chen MicroRNAs in brain function and disease Curr. Neurol. Neurosci. Rep. 8 2008 190 197
20. M. Lagos-Quintana, R. Rauhut, A. Yalcin, J. Meyer, W. Lendeckel, and T. Tuschl Identification of tissue-specific microRNAs from mouse Curr. Biol. 12 2002 735 739
21. J.M. Launay, S. Mouillet-Richard, A. Baudry, M. Pietri, and O. Kellermann Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16 Transl. Psychiatry 1 2011 e56
22. C.D. Mathers, and D. Loncar Projections of global mortality and burden of disease from 2002 to 2030 PLoS Med. 3 2006 e442
23. S. Mouillet-Richard, A. Baudry, J.M. Launay, and O. Kellermann MicroRNAs and depression Neurobiol. Dis. 46 2012 272 278
24. P.R. Moya, J.R. Wendland, J. Salemme, R.L. Fried, and D.L. Murphy miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells Int. J. Neuropsychopharmacol. 16 2013 621 629
25. M. Muller, H.B. Kuiperij, J.A. Claassen, B. Kusters, and M.M. Verbeek MicroRNAs in Alzheimer's disease: differential expression in hippocampus and cell-free cerebrospinal fluid Neurobiol. Aging 35 2014 152 158
26. K. Oved, A. Morag, M. Pasmanik-Chor, V. Oron-Karni, N. Shomron, M. Rehavi, J.C. Stingl, and D. Gurwitz Genome-wide miRNA expression profiling of human lymphoblastoid cell lines identifies tentative SSRI antidepressant response biomarkers Pharmacogenomics 13 2012 1129 1139
27. K.M. Ryan, S.M. O'Donovan, and D.M. McLoughlin Electroconvulsive stimulation alters levels of BDNF-associated microRNAs Neurosci. Lett. 549 2013 125 129
28. E. Saus, V. Soria, G. Escaramis, F. Vivarelli, J.M. Crespo, B. Kagerbauer, J.M. Menchon, M. Urretavizcaya, M. Gratacos, and X. Estivill Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia Hum. Mol. Genet. 19 2010 4017 4025
29. F. Sheikhmoonesi, and M. Zarghami Prevention of physicians' suicide Iran. J. Psychiatry Behav. Sci. 8 2014 1 3
30. N.R. Smalheiser, G. Lugli, H.S. Rizavi, V.I. Torvik, G. Turecki, and Y. Dwivedi MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects PLoS One 7 2012 e33201
31. A. Turchinovich, L. Weiz, A. Langheinz, and B. Burwinkel Characterization of extracellular circulating microRNA Nucleic Acids Res. 39 2011 7223 7233
32. E. van Rooij, L.B. Sutherland, X. Qi, J.A. Richardson, J. Hill, and E.N. Olson Control of stress-dependent cardiac growth and gene expression by a microRNA Science 316 2007 575 579
33. Y. Xu, H. Liu, F. Li, N. Sun, Y. Ren, Z. Liu, X. Cao, Y. Wang, P. Liu, and K. Zhang A polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveform J. Affect. Disord. 127 2010 332 336