Gastrodin ameliorates oleic acid-induced fat accumulation through activation of AMPK pathway in HL-7702 cells

Chinese Pharmacological Bulletin

Volumn 31, Issue 1, 2015, Pages 39-44

  Geng, Ya Na ^a   Yu, Bin ^a   Kong, Wei Jia ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

AMPK; Gastrodin; HL 7702; Oleic acid; Steatosis; Triglyceride

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ADENYLATE KINASE; GASTRODIN; OLEIC ACID; TRIACYLGLYCEROL;

ARTICLE; CELL VIABILITY; DRUG INHIBITION; INHIBITION KINETICS; LIPID STORAGE; MTT ASSAY; PROTEIN PHOSPHORYLATION; STAINING; STEATOSIS; WESTERN BLOTTING;

EID: 84924754828     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1001-1978.2015.01.010     Document Type: Article

References (15)

1. Fan J G. Epidemiology of alcoholic and nonalcoholic fatty liver disease in China [J]. J Gastroenterol Hepatol, 2013, 28 (Suppl. 1): 11-7.
2. Tao Y H. Recent progress on pharmacological effects of Gastrodia elata [J]. China J Chin Mat Med, 2008, 33 (1): 108-10.
3. Yu B, Zuo Z Y, Jiang J D. Experimental study on the antihyper-lipidemia effect of Gastrodina commen-pulverization and Gastrodin [J]. Chin Med Biotechnol, 2010, 5 (6): 415-8.
4. Meng B H, Li W J, Yu Z P, et al. Effects of Gastrodine on rabbit platelets aggregation in vitro [J]. Pharmacol Clin Chin Mater Med, 2006, 22 (3-4). 46-7.
5. Geng Y N, Yu B, Zuo Z Y, et al. Experimental study of Gastrodia powder in improving hepatic steatosis in rats intragastrically administered with fat emulsion [J]. China Med Her, 2013, 10 (30): 11-5.
6. Okamoto Y, Tanaka S, Haga Y. Enhanced GLUT2 gene expression in an oleic acid-induced in vitro fatty liver model [J]. Hepatol Res, 2002, 23(2): 138-44.
7. Quan H Y, Kim D Y, Kim S J, et al. Betulinie acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway [J]. Biochem Pharmacol, 2013, 85 (9): 1330-40.
8. Wang J J, Long T, Cao X, et al. The influence of Flavonoids extracted from lotus on the triglyceride metabolism of HepG2 cells incubated in oleic acid [J]. Chin Pharmacol Bull, 2010, 26 (12): 1626-30.
9. Hardie D G. AMPK: a key regulator of energy balance in the single cell and the whole organism [J]. Int J Obes (Load), 2008, 32 (Suppl. 4): 7-12.
10. Niu Y, Li S, Na L, et al. Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK [J]. PLoS One, 2012, 7 (1): e30782.
11. Yu B, Zuo Z Y, Kong W J. Experimental studies of the toxicity and safety of Gastrodina elata powder tablets [J]. China Mod Med, 2014, 21 (21): 6-10.
12. Cui W, Chen S L, Hu K Q. Quantification and mechanisms of o-leic acid-induced steatosis in HepG2 cells [J]. Am J Transi Res, 2010, 2(1): 95-104.
13. Liao C C, Ou TT, Huang H P, et al. The inhibition of oleic acid induced hepatic lipogenesis and the promotion of lipolysis by caffeic acid via up-regulation of AMP-activated kinase [J]. J Sci Food Agric, 2014, 94 (6): 1154-62.
14. Yin J, Gao Z, Liu D, et al. Berberine improves glucose metabolism through induction of glycolysis [J]. Am J Physiol Endocrinol Metab, 2008, 294 (1): 148-56.
15. Bang S, Chen Y, Ahima R S, et al. Convergence of IPMK and LKB1-AMPK signaling pathways on metformin action [J]. Mol Endocrinol, 2014, 28(7): 1186-93.