Urinary bile acids as biomarkers for liver diseases I. stability of the baseline profile in healthy subjects

Toxicological Sciences

Volumn 143, Issue 2, 2015, Pages 296-307

  Bathena, Sai Praneeth R ^a   Thakare, Rhishikesh ^a   Gautam, Nagsen ^a   Mukherjee, Sandeep ^b   Olivera, Marco ^b   Meza, Jane ^c   Alnouti, Yazen ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Bile acid profile; Healthy subjects; Serum bile acid; Stability; Urinary bile acid; Variability

Indexed keywords

BILE ACID; BIOLOGICAL MARKER; AMIDE; SULFATE;

ADULT; AGE; AGED; ALCOHOL CONSUMPTION; AMIDATION; ARTICLE; BEER; BILE ACID BLOOD LEVEL; BODY MASS; FEMALE; FOOD INTAKE; GENDER; HUMAN; HUMAN EXPERIMENT; LIVER DISEASE; MALE; NORMAL HUMAN; SULFATION; URINE LEVEL; WINE; BLOOD; CHEMISTRY; DRINKING BEHAVIOR; DRUG STABILITY; MIDDLE AGED; SEX DIFFERENCE; STATISTICAL ANALYSIS; URINE; YOUNG ADULT;

ADULT; AGE FACTORS; AGED; ALCOHOL DRINKING; AMIDES; BILE ACIDS AND SALTS; BIOLOGICAL MARKERS; DATA INTERPRETATION, STATISTICAL; DRUG STABILITY; FEMALE; HEALTHY VOLUNTEERS; HUMANS; LIVER DISEASES; MALE; MIDDLE AGED; SEX FACTORS; SULFATES; YOUNG ADULT;

EID: 84924664029     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu227     Document Type: Article

References (60)

1. Alnouti, Y. (2009). Bile acid sulfation: a pathway of bile acid elimination and detoxification. Toxicol. Sci. 108, 225-246.
2. Alnouti, Y., and Klaassen, C. D. (2006). Tissue distribution and ontogeny of sulfotransferase enzymes in mice. Toxicol. Sci. 93, 242-255.
3. Alnouti, Y., and Klaassen, C. D. (2008). Regulation of sulfotransferase enzymes by prototypical microsomal enzyme inducers in mice. J. Pharmacol. Exp. Ther. 324, 612-621.
4. Angelin, B., and Björkhem, I. (1977). Postprandial serum bile acids in healthy man. Evidence for differences in absorptive pattern between individual bile acids. Gut 18, 606-609.
5. Barbara, L., Lazzari, R., Roda, A., Aldini, R., Festi, D., Sama, C., Morselli, A.M., Collina, A., Bazzoli, F., Mazzella, G., et al. (1980). Serum bile acids in newborns and children. Pediatr. Res. 14, 1222-1225.
6. Barnes, S., Burhol, P. G., Zander, R., Haggstrom, G., Settine, R. L., and Hirschowitz, B. I. (1979a). Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamsters. J. Lipid Res. 20, 952-959.
7. Barnes, S., Burhol, P. G., Zander, R., and Hirschowitz, B. I. (1979b). The effect of bile duct ligation on hepatic bile acid sulfotransferase activity in the hamster. Biochem. Med. 22, 165-174.
8. Bathena, S. P., Mukherjee, S., Olivera, M., and Alnouti, Y. (2013). The profile of bile acids and their sulfate metabolites in human urine and serum. J. Chromatogr. B. 942-943, 53-62.
9. Bertolotti, M., Gabbi, C., Anzivino, C., Crestani, M., Mitro, N., Del Puppo, M., Godio, C., De Fabiani, E., Macchioni, D., Carulli, L., et al. (2007). Age-related changes in bile acid synthesis and hepatic nuclear receptor expression. Eur. J. Clin. Invest. 37, 501-508.
10. Chen, G., Baron, J., and Duffel, M. W. (1995). Enzyme- and sexspecific differences in the intralobular localizations and distributions of aryl sulfotransferase IV (tyrosine-ester sulfotransferase) and alcohol (hydroxysteroid) sulfotransferase a in rat liver. Drug. Metab. Dispos. 23, 1346-1353.
11. Chiang, J. Y. (2009). Bile acids: regulation of synthesis. J. Lipid Res. 50, 1955-1966.
12. Crouse, J. R., and Grundy, S. M. (1984). Effects of alcohol on plasma lipoproteins and cholesterol and triglyceride metabolism in man. J. Lipid Res. 25, 486-496.
13. Duane, W. C., Levitt, D. G., Mueller, S. M., and Behrens, J. C. (1983). Regulation of bile acid synthesis in man. Presence of a diurnal rhythm. J. Clin. Invest. 72, 1930-1936.
14. Dunn, R. T., 2nd, and Klaassen, C. D. (1998). Tissue-specific expression of rat sulfotransferase messenger RNAs. Drug. Metab. Dispos. 26, 598-604.
15. Einarsson, K., Nilsell, K., Leijd, B., and Angelin, B. (1985). Influence of age on secretion of cholesterol and synthesis of bile acids by the liver. N. Engl. J. Med. 313, 277-282.
16. Fischer, S., Beuers, U., Spengler, U., Zwiebel, F. M., and Koebe, H. G. (1996). Hepatic levels of bile acids in end-stage chronic cholestatic liver disease. Clin. Chim. Acta 251, 173-186.
17. Galman, C., Angelin, B., and Rudling, M. (2005). Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis. Gastroenterology 129, 1445-1453.
18. Glicksman, C., Pournaras, D. J., Wright, M., Roberts, R., Mahon, D., Welbourn, R., Sherwood, R., Alaghband-Zadeh, J., and le Roux, C. W. (2010). Postprandial plasma bile acid responses in normal weight and obese subjects. Ann. Clin. Biochem. 47, 482-484.
19. Hammerman, K. J., Chen, L. J., Fernandez-Corugedo, A., and Earnest, D. L. (1978). Sex differences in hepatic sulfation of taurolithocholate in the rat. Gastroenterology 75, 1021-1025.
20. Heuman, D. M., Pandak, W. M., Hylemon, P. B., and Vlahcevic, Z. R. (1991). Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: in vitro studies in rat hepatocytes and human erythrocytes. Hepatology 14, 920-926.
21. Hofmann, A. F. (1999). The continuing importance of bile acids in liver and intestinal disease. Arch. Intern. Med. 159, 2647-2658.
22. Hofmann, A. F., Grundy, S. M., Lachin, J. M., Lan, S. P., Baum, R. A., Hanson, R. F., Hersh, T., Hightower, N. C. Jr, Marks, J. W., Mekhjian, H., et al. (1982). Pretreatment biliary lipid composition in white patients with radiolucent gallstones in the National Cooperative Gallstone Study. Gastroenterology 83, 738-752.
23. Huang, W. M., Seubert, D. E., Donnelly, J. G., Liu, M., and Javitt, N. B. (2007). Intrahepatic cholestasis of pregnancy: detection with urinary bile acid assays. J. Perinat. Med. 35, 486-491.
24. Islam, S., Poupon, R. E., Barbare, J. C., Chretien, Y., Darnis, F., and Poupon, R. (1985). Fasting serum bile acid level in cirrhosis. A semi-quantitative index of hepatic function. J. Hepatol. 1, 609-617.
25. Joelsson, B., Hultberg, B., Isaksson, A., Alwmark, A., Gullstrand, P., and Bengmark, S. (1984). Total fasting serum bile acids and beta-hexosaminidase in alcoholic liver disease. Clin. Chim. Acta 136, 203-209.
26. Jonsson, G., Hedenborg, G., Wisen, O., and Norman, A. (1992). Serum concentrations and excretion of bile acids in cirrhosis. Scand. J. Clin. Lab. Invest. 52, 599-605.
27. Kawasaki, H., Yamanishi, Y., Miyake, M., Mura, T., and Ikawa, S. (1986). Age- and sex-related profiles of serum primary and total bile acids in infants, children and adults. Tohoku. J. Exp. Med. 150, 353-357.
28. Kerai, M. D., Waterfield, C. J., Kenyon, S. H., Asker, D. S., and Timbrell, J. A. (1998). Taurine: protective properties against ethanol-induced hepatic steatosis and lipid peroxidation during chronic ethanol consumption in rats. Amino Acids. 15, 53-76.
29. Kerai, M. D., Waterfield, C. J., Kenyon, S. H., Asker, D. S., and Timbrell, J. A. (2001). The effect of taurine depletion by betaalanine treatment on the susceptibility to ethanol-induced hepatic dysfunction in rats. Alcohol Alcohol. 36, 29-38.
30. Lucangioli, S. E., Castano, G., Contin, M. D., and Tripodi, V. P. (2009). Lithocholic acid as a biomarker of intrahepatic cholestasis of pregnancy during ursodeoxycholic acid treatment. Ann. Clin. Biochem. 46, 44-49.
31. Maillette de Buy Wenniger, L., and Beuers, U. (2010). Bile salts and cholestasis. Dig. Liver Dis. 42, 409-418.
32. Makino, I., Hashimoto, H., Shinozaki, K., Yoshino, K., and Nakagawa, S. (1975). Sulfated and nonsulfated bile acids in urine, serum, and bile of patients with hepatobiliary diseases. Gastroenterology 68, 545-553.
33. Mannes, G. A., Stellaard, F., and Paumgartner, G. (1982). Increased serum bile acids in cirrhosis with normal transaminases. Digestion 25, 217-221.
34. Milstein, H. J., Bloomer, J. R., and Klatskin, G. (1976). Serum bile acids in alcoholic liver disease. Comparison with histological features of the disease. Am. J. Dig. Dis. 21, 281-285.
35. Monte, M. J., Marin, J. J., Antelo, A., and Vazquez-Tato, J. (2009). Bile acids: chemistry, physiology, and pathophysiology. World J. Gastroenterol. 15, 804-816.
36. Muraji, T., Harada, T., Miki, K., Moriuchi, T., Obatake, M., and Tsugawa, C. (2003). Urinary sulfated bile acid concentrations in infants with biliary atresia and breast-feeding jaundice. Pediatr. Int. 45, 281-283.
37. Nestel, P. J., Simons, L. A., and Homma, Y. (1976). Effects of ethanol on bile acid and cholesterol metabolism. Am. J. Clin. Nutr. 29, 1007-1015.
38. Okolicsanyi, L., Lirussi, F., Strazzabosco, M., Jemmolo, R. M., Orlando, R., Nassuato, G., Muraca, M., and Crepaldi, G. (1986). The effect of drugs on bile flow and composition. An overview. Drugs 31, 430-448.
39. Pagano, M., and Gauvreau, K. (2000). Principles of Biostatistics. Brooks/Cole, Pacific Grove, CA.
40. Patti, M. E., Houten, S. M., Bianco, A. C., Bernier, R., Larsen, P. R., Holst, J. J., Badman, M. K., Maratos-Flier, E., Mun, E. C., Pihlajamaki, J., et al. (2009). Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring) 17, 1671-1677.
41. Pauli-Magnus, C., and Meier, P. J. (2005). Hepatocellular transporters and cholestasis. J. Clin. Gastroenterol. 39, S103-S110.
42. Pennington, C. R., Ross, P. E., and Bouchier, I. A. (1977). Serum bile acids in the diagnosis of hepatobiliary disease. Gut 18, 903-908.
43. Pikaar, N. A., Wedel, M., van der Beek, E. J., van Dokkum, W., Kempen, H. J., Kluft, C., Ockhuizen, T., and Hermus, R. J. (1987). Effects of moderate alcohol consumption on platelet aggregation, fibrinolysis, and blood lipids. Metabolism 36, 538-543.
44. Poupon, R. Y., Poupon, R. E., Lebrec, D., Le Quernec, L., and Darnis, F. (1981). Mechanisms for reduced hepatic clearance and elevated plasma levels of bile acids in cirrhosis. A study in patients with an end-to-side portacaval shunt. Gastroenterology 80, 1438-1444.
45. Schalm, S. W., LaRusso, N. F., Hofmann, A. F., Hoffman, N. E., van Berge-Henegouwen, G. P., and Korman, M. G. (1978). Diurnal serum levels of primary conjugated bile acids. Assessment by specific radioimmunoassays for conjugates of cholic and chenodeoxycholic acid. Gut 19, 1006-1014.
46. Setchell, K. D., Lawson, A. M., Blackstock, E. J., and Murphy, G. M. (1982). Diurnal changes in serum unconjugated bile acids in normal man. Gut 23, 637-642.
47. Shaffer, E. A., and Gordon, E. R. (1978). Serum bile acids as related to bile acid secretion in liver disease. Am. J. Dig. Dis. 23, 392-397.
48. Simko, V., Ferris, R. K.,Michael, S., and Zachary, K. (1988). Random urine bile acids in predictionof liver abnormality inasymptomatic alcoholics. Arch. Intern. Med. 148, 312-315.
49. Simko, V., and Michael, S. (1998). Urinary bile acids in population screening for inapparent liver disease. Hepatogastroenterology 45, 1706-1714.
50. Simko, V., Michael, S., and Kelley, R. E. (1987). Predictive value of random sample urine bile acids corrected by creatinine in liver disease. Hepatology 7, 115-121.
51. Sinakos, E., and Lindor, K. D. (2010). Bile acid profiles in intrahepatic cholestasis of pregnancy: is this the solution to the enigma of intrahepatic cholestasis of pregnancy? Am. J. Gastroenterol. 105, 596-598.
52. Starkey, B. J., and Marks, V. (1982). Determination of total bile acids in serum. A comparison of a radioimmunoassay with an enzymatic-fluorimetricmethod. Clin. Chim. Acta 119, 165-177.
53. Steiner, C., Othman, A., Saely, C. H., Rein, P., Drexel, H., von Eckardstein, A., and Rentsch, K. M. (2011). Bile acid metabolites in serum: intraindividual variation and associations with coronary heart disease, metabolic syndrome and diabetes mellitus. PLoS One 6, e25006.
54. Styles, N. A., Falany, J. L., Barnes, S., and Falany, C. N. (2007). Quantification and regulation of the subcellular distribution of bile acid coenzyme A:amino acid N-acyltransferase activity in rat liver. J. Lipid Res. 48, 1305-1315.
55. Thomas, C., Pellicciari, R., Pruzanski, M., Auwerx, J., and Schoonjans, K. (2008). Targeting bile-acid signalling for metabolic diseases. Nat. Rev. Drug Discov. 7, 678-693.
56. Tobiasson, P., and Boeryd, B. (1980). Serum cholic and chenodeoxycholic acid conjugates and standard liver function tests in various morphological stages of alcoholic liver disease. Scand. J. Gastroenterol. 15, 657-663.
57. Trinchet, J. C., Gerhardt, M. F., Balkau, B., Munz, C., and Poupon, R. E. (1994). Serum bile acids and cholestasis in alcoholic hepatitis. Relationship with usual liver tests and histological features. J. Hepatol. 21, 235-240.
58. Trottier, J., Caron, P., Straka, R. J., and Barbier, O. (2011). Profile of serum bile acids in noncholestatic volunteers: gender-related differences in response to fenofibrate. Clin. Pharmacol. Ther. 90, 279-286.
59. van Berge Henegouwen, G. P., Brandt, K. H., Eyssen, H., and Parmentier, G. (1976). Sulphated and unsulphated bile acids in serum, bile, and urine of patients with cholestasis. Gut 17, 861-869.
60. Xiang, X., Backman, J. T., Neuvonen, P. J., and Niemi, M. (2012). Gender, but not CYP7A1 or SLCO1B1 polymorphism, affects the fasting plasma concentrations of bile acidsin human beings. Basic Clin. Pharmacol. Toxicol. 110, 245-252.