Association of serum total bilirubin level with severity of coronary atherosclerosis is linked to systemic inflammation

Atherosclerosis

Volumn 240, Issue 1, 2015, Pages 110-114

  Akboga, Mehmet Kadri ^a   Canpolat, Ugur ^a   Sahinarslan, Asife ^b   Alsancak, Yakup ^b   Nurkoc, Serdar ^b   Aras, Dursun ^a   Aydogdu, Sinan ^a   Abaci, Adnan ^b  

^a TURKIYE YUKSEK IHTISAS HOSPITAL   (Turkey)

^b GAZI UNIVERSITY FACULTY OF MEDICINE   (Turkey)

Author keywords

Atherosclerosis; Bilirubin; CRP; Inflammation; NLR; RDW

Indexed keywords

ANTIHYPERTENSIVE AGENT; BILIRUBIN; C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; AUTACOID; BIOLOGICAL MARKER;

ADULT; ANGIOCARDIOGRAPHY; ANTIHYPERTENSIVE THERAPY; ARTICLE; BILIRUBIN BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY OBSTRUCTION; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ERYTHROCYTE; ERYTHROCYTE DISTRIBUTION WIDTH; ERYTHROCYTE PARAMETERS; FEMALE; GENSINI SCORE; HEART LEFT VENTRICLE EJECTION FRACTION; HEMATOLOGICAL PARAMETERS; HUMAN; HUMAN CELL; HYPERTENSION; INFLAMMATION; LABORATORY TEST; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEUTROPHIL COUNT; NEUTROPHIL LYMPHOCYTE RATIO; PREDICTIVE VALUE; PRIORITY JOURNAL; RED CELL DISTRIBUTION WIDTH; RETROSPECTIVE STUDY; SERUM; THROMBOCYTE VOLUME; AGED; BLOOD; CHI SQUARE DISTRIBUTION; CORONARY ARTERY DISEASE; IMMUNOLOGY; LYMPHOCYTE; LYMPHOCYTE COUNT; MEAN CORPUSCULAR VOLUME; NEUTROPHIL; PROTECTION; RISK FACTOR; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL;

ADULT; AGED; BILIRUBIN; BIOMARKERS; C-REACTIVE PROTEIN; CHI-SQUARE DISTRIBUTION; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; CROSS-SECTIONAL STUDIES; ERYTHROCYTE INDICES; FEMALE; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LINEAR MODELS; LYMPHOCYTE COUNT; LYMPHOCYTES; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEUTROPHILS; PREDICTIVE VALUE OF TESTS; PROTECTIVE FACTORS; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 84924599499     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2015.02.051     Document Type: Article

References (32)

1. Libby P., Ridker P.M., Maseri A. Inflammation and atherosclerosis. Circulation 2002, 105:1135-1143.
2. Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease. N.Engl. J. Med. 2005, 352:1685-1695.
3. Witztum J.L., Berliner J.A. Oxidized phospholipids and isoprostanes in atherosclerosis. Curr. Opin. Lipidol. 1998, 9:441-448.
4. Steinberg D., Parthasarathy S., Carew T.E., Khoo J.C., Witztum J.L. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N.Engl. J. Med. 1989, 320:915-924.
5. Stocker R., Yamamoto Y., McDonagh A.F., Glazer A.N., Ames B.N. Bilirubin is an antioxidant of possible physiological importance. Science 1987, 235:1043-1046.
6. Dennery P.A., McDonagh A.F., Spitz D.R., Rodgers P.A., Stevenson D.K. Hyperbilirubinemia results in reduced oxidative injury in neonatal gunn rats exposed to hyperoxia. Free Radic. Biol. Med. 1995, 19:395-404.
7. Wu T.W., Fung K.P., Wu J., Yang C.C., Weisel R.D. Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins. Biochem. Pharmacol. 1996, 51:859-862.
8. Kang S.J., Kim D., Park H.E., Chung G.E., Choi S.H., Choi S.Y., et al. Elevated serum bilirubin levels are inversely associated with coronary artery atherosclerosis. Atherosclerosis 2013, 230:242-248.
9. Ghem C., Sarmento-Leite R.E., de Quadros A.S., Rossetto S., Gottschall C.A. Serum bilirubin concentration in patients with an established coronary artery disease. Int. Heart J. 2010, 51:86-91.
10. Turfan M., Duran M., Poyraz F., Yayla C., Akboga M.K., Sahinarslan A., et al. Inverse relationship between serum total bilirubin levels and severity of disease in patients with stable coronary artery disease. Coron. Artery Dis. 2013, 24:29-32.
11. Claridge L.C., Armstrong M.J., Booth C., Gill P.S. Gilbert's syndrome. BMJ 2011, 342:d2293.
12. Gensini G.G. Amore meaningful scoring system for determining the severity of coronary heart disease. Am. J. Cardiol. 1983, 51:606.
13. Oishi Y., Wakatsuki T., Nishikado A., Oki T., Ito S. Circulating adhesion molecules and severity of coronary atherosclerosis. Coron. Artery Dis. 2000, 11:77-81.
14. Fihn S.D., Gardin J.M., Abrams J., Berra K., Blankenship J.C., Dallas A.P., et al. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J.Am. Coll. Cardiol. 2012, 60:44-164.
15. Drakopoulou M., Toutouzas K., Stefanadi E., Tsiamis E., Tousoulis D., Stefanadis C. Association of inflammatory markers with angiographic severity and extent of coronary artery disease. Atherosclerosis 2009, 206:335-339.
16. Witztum J.L., Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J.Clin. Invest. 1991, 88:1785-1792.
17. Neuzil J., Stocker R. Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation. J.Biol. Chem. 1994, 269:16712-16729.
18. Schwertner H.A., Jackson W.G., Tolan G. Association of low serum concentration of bilirubin with increased risk of coronary artery disease. Clin. Chem. 1994, 40:18-23.
19. Novotny L., Vitek L. Inverse relationship between serum bilirubin and atherosclerosis in men: a meta-analysis of published studies. Exp. Biol. Med. (Maywood) 2003, 228:568-571.
20. Gul M., Uyarel H., Ergelen M., Akgul O., Karaca G., Turen S., et al. Prognostic value of total bilirubin in patients with ST-segment elevation acute myocardial infarction undergoing primary coronary intervention. Am. J. Cardiol. 2013, 111:166-171.
21. Lin J.P., O'Donnell C.J., Schwaiger J.P., Cupples L.A., Lingenhel A., Hunt S.C., et al. Association between the UGT1A1*28 allele, bilirubin levels, and coronary heart disease in the framingham heart study. Circulation 2006, 114:1476-1481.
22. Sung K.C., Shin J., Lim Y.H., Wild S.H., Byrne C.D. Relation of conjugated bilirubin concentrations to the presence of coronary artery calcium. Am. J. Cardiol. 2013, 112:1873-1879.
23. Crisby M., Kublickiene K., Henareh L., Agewall S. Circulating levels of autoantibodies to oxidized low-density lipoprotein and C-reactive protein levels correlate with endothelial function in resistance arteries in men with coronary heart disease. Heart Vessels 2009, 24:90-95.
24. Arbel Y., Finkelstein A., Halkin A., Birati E.Y., Revivo M., Zuzut M., et al. Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography. Atherosclerosis 2012, 225:456-460.
25. Wang X., Zhang G., Jiang X., Zhu H., Lu Z., Xu L. Neutrophil to lymphocyte ratio in relation to risk of all-cause mortality and cardiovascular events among patients undergoing angiography or cardiac revascularization: a meta-analysis of observational studies. Atherosclerosis 2014, 234:206-213.
26. Tonelli M., Sacks F., Arnold M., Moye L., Davis B., Pfeffer M., for the Cholesterol and Recurrent Events (CARE) Trial Investigators Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 2008, 117:163-168.
27. Danesh J., Wheeler J.G., Hirschfield G.M., Eda S., Eiriksdottir G., Rumley A., et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N.Engl. J. Med. 2004, 350:1387-1397.
28. Tanindi A., Erkan A.F., Ekici B., Alhan A., Töre H.F. Neutrophil to lymphocyte ratio is associated with more extensive, severe and complex coronary artery disease and impaired myocardial perfusion. Turk. Kardiyol. Dern. Ars 2014, 42:125-130.
29. Akboga M.K., Akyel A., Sahinarslan A., Yayla C., Alsancak Y., Gokalp G., et al. Neutrophil to lymphocyte ratio is increased in patients with rheumatic mitral valve stenosis?. Anadolu. Kardiyol. Derg. 2014 Apr 16., (Epub ahead of print). 10.5152/akd.2014.5399.
30. Isik T., Kurt M., Ayhan E., Tanboga I.H., Ergelen M., Uyarel H. The impact of admission red cell distribution width on the development of poor myocardial perfusion after primary percutaneous intervention. Atherosclerosis 2012, 224:143-149.
31. Tapan S., Dogru T., Tasci I., Ercin C.N., Ozgurtas T., Erbil M.K. Soluble CD40 ligand and soluble P-selectin levels in Gilbert's syndrome: a link to protection against atherosclerosis?. Clin. Biochem. 2009, 42:791-795.
32. Yoshino S., Hamasaki S., Ishida S., Kataoka T., Yoshikawa A., Oketani N., et al. Relationship between bilirubin concentration, coronary endothelial function, and inflammatory stress in overweight patients. J.Atheroscler. Thromb. 2011, 18:403-412.