Down-regulation of Frizzled-7 expression inhibits migration, invasion, and epithelial–mesenchymal transition of cervical cancer cell lines

Medical Oncology

Volumn 32, Issue 4, 2015, Pages

  Deng, Boya ^a   Zhang, Siyang ^a   Miao, Yuan ^a   Zhang, Yi ^a   Wen, Fang ^a   Guo, Kejun ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Cervical cancer; Epithelial mesenchymal transition; Frizzled 7; JNK c jun; Metastasis

Indexed keywords

FRIZZLED PROTEIN; FRIZZLED PROTEIN 7; GELATINASE A; GELATINASE B; MESSENGER RNA; PROTEIN C JUN; SHORT HAIRPIN RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; CADHERIN; FZD7 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ARTICLE; CELL COUNT; CELL GROWTH; CELL INVASION; CERVICAL CANCER CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; METASTASIS; MIGRATION INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; UTERINE CERVIX CANCER; WNT SIGNALING PATHWAY; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL MOTION; CELL PROLIFERATION; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; TUMOR INVASION; UTERINE CERVIX TUMOR; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CADHERINS; CELL MOVEMENT; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; FRIZZLED RECEPTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM INVASIVENESS; PHOSPHORYLATION; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; UTERINE CERVICAL NEOPLASMS;

EID: 84924589152     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-015-0552-8     Document Type: Article

References (32)

1. Crosbie EJ, Einstein MH, Franceschi S, Kitchener HC. Human papillomavirus and cervical cancer. Lancet. 2013;382(9895):889–99.
2. Arbyn M, Castellsague X, de Sanjose S, Bruni L, Saraiya M, Bray F, et al. Worldwide burden of cervical cancer in 2008. Ann Oncol. 2011;22(12):2675–86. doi:10.1093/annonc/mdr015.
3. Partridge EE, Abu-Rustum N, Giuliano A, Massad S, McClure J, Dwyer M, et al. Cervical cancer screening. J Natl Compr Cancer Netw. 2014;12(3):333–41.
4. Kwak K, Yemelyanova A, Roden R. Prevention of cancer by prophylactic human papillomavirus vaccines. Curr Opin Immunol. 2011;23(2):244–51.
5. Manzo-Merino J, Contreras-Paredes A, Vazquez-Ulloa E, Rocha-Zavaleta L, Fuentes-Gonzalez AM, Lizano M. The role of signaling pathways in cervical cancer and molecular therapeutic targets. Arch Med Res. 2014;45(7):525–39. doi:10.1016/j.arcmed.2014.10.008.
6. Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature. 2005;434(7035):843–50.
7. Giles RH, van Es JH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochimica Biophysica Acta (BBA) Rev Cancer. 2003;1653(1):1–24.
8. Perez-Plasencia C, Duenas-Gonzalez A, Alatorre-Tavera B. Second hit in cervical carcinogenesis process: involvement of wnt/beta catenin pathway. Int Arch Med. 2008;1(1):10.
9. Nambotin SB, Lefrancois L, Sainsily X, Berthillon P, Kim M, Wands JR, et al. Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma. J Hepatol. 2011;54(2):288–99.
10. Barker N, Clevers H. Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov. 2006;5(12):997–1014. doi:10.1038/nrd2154.
11. Dann CE, Hsieh J-C, Rattner A, Sharma D, Nathans J, Leahy DJ. Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature. 2001;412(6842):86–90.
12. Kirikoshi H, Sekihara H, Katoh M. Up-regulation of Frizzled-7 (FZD7) in human gastric cancer. Int J Oncol. 2001;19(1):111–5.
13. Yang L, Wu X, Wang Y, Zhang K, Wu J, Yuan Y, et al. FZD7 has a critical role in cell proliferation in triple negative breast cancer. Oncogene. 2011;30(43):4437–46.
14. Merle P, Kim M, Herrmann M, Gupte A, Lefrançois L, Califano S, et al. Oncogenic role of the frizzled-7/β-catenin pathway in hepatocellular carcinoma. J Hepatol. 2005;43(5):854–62.
15. Ueno K, Hiura M, Suehiro Y, Hazama S, Hirata H, Oka M, et al. Frizzled-7 as a potential therapeutic target in colorectal cancer. Neoplasia. 2008;10(7):697–705.
16. Asad M, Wong MK, Tan TZ, Choolani M, Low J, Mori S, et al. FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway. Cell Death Dis. 2014;5:e1346. doi:10.1038/cddis.2014.302.
17. King TD, Zhang W, Suto MJ, Li Y. Frizzled7 as an emerging target for cancer therapy. Cell Signal. 2012;24(4):846–51. doi:10.1016/j.cellsig.2011.12.009.
18. Chung M-T, Lai H-C, Sytwu H-K, Yan M-D, Shih Y-L, Chang C-C, et al. SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway. Gynecol Oncol. 2009;112(3):646–53. doi:10.1016/j.ygyno.2008.10.026.
19. Zi X, Guo Y, Simoneau AR, Hope C, Xie J, Holcombe RF, et al. Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Res. 2005;65(21):9762–70.
20. Qureshi R, Arora H, Rizvi M. EMT in cervical cancer: its role in tumour progression and response to therapy. Cancer Lett. 2015;356(2):321–31.
21. Menezes ME. The Wnt/β-catenin signaling pathway in epithelial mesenchymal transition. J Postdoc Res July. 2014;1:12.
22. Yook JI, Li X-Y, Ota I, Fearon ER, Weiss SJ. Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem. 2005;280(12):11740–8.
23. Steeg PS. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med. 2006;12(8):895–904.
24. Deryugina EI, Quigley JP. Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev. 2006;25(1):9–34. doi:10.1007/s10555-006-7886-9.
25. Moss LAS, Jensen-Taubman S, Stetler-Stevenson WG. Matrix metalloproteinases: changing roles in tumor progression and metastasis. Am J Pathol. 2012;181(6):1895–9.
26. Sheu B-C, Lien H-C, Ho H-N, Lin H-H, Chow S-N, Huang S-C, et al. Increased expression and activation of gelatinolytic matrix metalloproteinases is associated with the progression and recurrence of human cervical cancer. Cancer Res. 2003;63(19):6537–42.
27. Scheel C, Weinberg RA, editors. Cancer stem cells and epithelial–mesenchymal transition: concepts and molecular links. Seminars in cancer biology. Amsterdam: Elsevier; 2012.
28. Xiang T, Li L, Yin X, Zhong L, Peng W, Qiu Z, et al. Epigenetic silencing of the WNT antagonist Dickkopf 3 disrupts normal Wnt/β-catenin signalling and apoptosis regulation in breast cancer cells. J Cell Mol Med. 2013;17(10):1236–46.
29. Veeck J, Dahl E. Targeting the Wnt pathway in cancer: the emerging role of Dickkopf-3. Biochimica Biophysica Acta (BBA) Rev Cancer. 2012;1825(1):18–28.
30. Vincan E, Barker N. The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression. Clin Exp Metastasis. 2008;25(6):657–63.
31. Kennedy NJ, Davis RJ. Role of JNK in tumor development. Cell Cycle (Georgetown, Tex). 2002;2(3):199–201.
32. Ueno K, Hazama S, Mitomori S, Nishioka M, Suehiro Y, Hirata H, et al. Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. Br J Cancer. 2009;101(8):1374–81.