Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: Oncogenic transformation with epithelial-mesenchymal transition

Stem Cell Reports

Volumn 4, Issue 3, 2015, Pages 360-373

  Nori, Satoshi ^a   Okada, Yohei ^a   Nishimura, Soraya ^a   Sasaki, Takashi ^a   Itakura, Go ^a   Kobayashi, Yoshiomi ^a   Renault Mihara, Francois ^a   Shimizu, Atsushi ^a   Koya, Ikuko ^a   Yoshida, Rei ^a   Kudoh, Jun ^a   Koike, Masato ^b   Uchiyama, Yasuo ^b   Ikeda, Eiji ^a,c   Toyama, Yoshiaki ^a   Nakamura, Masaya ^a   Okano, Hideyuki ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; BETA TUBULIN; BONE MORPHOGENETIC PROTEIN 2; CHOLINE ACETYLTRANSFERASE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE DECARBOXYLASE 67; KRUPPEL LIKE FACTOR 4; LYMPHOID ENHANCER FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; NESTIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN; PROTEIN SNAI 1; STAT3 PROTEIN; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR TWIST 1; TRANSCRIPTION FACTOR TWIST 2; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; TRANSCRIPTOME;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL CLONE; CELL DIFFERENTIATION; CELL SURVIVAL; CHOLINERGIC NERVE CELL; CLINICAL EVALUATION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOLOGICAL SYNAPSE; LAMINECTOMY; LONG TERM CARE; MOTOR PERFORMANCE; MOUSE; NERVE CELL; NEURAL STEM CELL; NONHUMAN; OBSERVATIONAL STUDY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; SPINAL CORD INJURY; STEM CELL TRANSPLANTATION; SURVIVAL RATE; TRANSGENE; TUMOR GROWTH; ADVERSE EFFECTS; ANIMAL; ASTROCYTE; BIOLOGY; CELL LINEAGE; CELL TRANSFORMATION; CLUSTER ANALYSIS; CYTOLOGY; DISEASE MODEL; GENE EXPRESSION PROFILING; GENETICS; GLIA; INDUCED PLURIPOTENT STEM CELL; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; SPINAL CORD INJURIES; XENOGRAFT;

ANIMALS; ASTROCYTES; CELL DIFFERENTIATION; CELL LINEAGE; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; DISEASE MODELS, ANIMAL; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION PROFILING; HETEROGRAFTS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; NEUROGLIA; NEURONS; SIGNAL TRANSDUCTION; SPINAL CORD INJURIES; STEM CELL TRANSPLANTATION; TRANSCRIPTOME;

EID: 84924574219     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2015.01.006     Document Type: Article

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