Progression of gait dysfunction in incident Parkinson's disease: Impact of medication and phenotype

Movement Disorders

Volumn 30, Issue 3, 2015, Pages 359-367

  Galna, Brook ^a   Lord, Sue ^a   Burn, David J ^a   Rochester, Lynn ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Gait; Longitudinal; Medication; Parkinson's disease; Phenotype

Indexed keywords

LEVODOPA; DOPAMINE RECEPTOR STIMULATING AGENT;

ADULT; AGED; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DETERIORATION; DISEASE COURSE; FEMALE; GAIT DISORDER; HUMAN; IDIOPATHIC DISEASE; MAJOR CLINICAL STUDY; MALE; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; RHYTHM; COGNITION DISORDERS; COMPLICATION; DISABILITY; GAIT DISORDERS, NEUROLOGIC; INCIDENCE; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; WALKING;

AGED; COGNITION DISORDERS; COHORT STUDIES; DISABILITY EVALUATION; DISEASE PROGRESSION; DOPAMINE AGENTS; FEMALE; GAIT DISORDERS, NEUROLOGIC; HUMANS; INCIDENCE; LEVODOPA; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PARKINSON DISEASE; PHENOTYPE; WALKING;

EID: 84924551490     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.26110     Document Type: Article

References (45)

1. Bryant MS, Rintala DH, Hou JG, et al. Gait variability in Parkinson's disease: influence of walking speed and dopaminergic treatment. Neurol Res 2011;33:959-964.
2. Bryant MS, Rintala DH, Hou JG, Lai EC, Protas EJ. Effects of levodopa on forward and backward gait patterns in persons with Parkinson's disease. Neurorehabilitation 2011;29:247-252.
3. Lord S, Baker K, Nieuwboer A, Burn D, Rochester L. Gait variability in Parkinson's disease: an indicator of non-dopaminergic contributors to gait dysfunction? J Neurol 2011;258:566-572.
4. Morris ME, Iansek R, Matyas TA, Summers JJ. The pathogenesis of gait hypokinesia in Parkinsons-disease. Brain 1994;117:1169-1181.
5. Vokaer M, Abou Azar N, de Beyl DZ. Effects of levodopa on upper limb mobility and gait in Parkinson's disease. J Neurol Neurosurg Psychiatry 2003;74:1304-1307.
6. Auyeung M, Tsoi TH, Mok V, et al. Ten year survival and outcomes in a prospective cohort of new onset Chinese Parkinson's disease patients. J Neurol Neurosurg Psychiatry 2012;83:607-611.
7. Kerr GK, Worringham CJ, Cole MH, Lacherez PF, Wood JM, Silburn PA. Predictors of future falls in Parkinson disease. Neurology 2010;75:116-124.
8. Taylor JP, Rowan EN, Lett D, O'Brien JT, McKeith IG, Burn DJ. Poor attentional function predicts cognitive decline in patients with non-demented Parkinson's disease independent of motor phenotype. J Neurol Neurosurg Psychiatry 2008;79:1318-1323.
9. Hass CJ, Malczak P, Nocera J, et al. Quantitative normative gait data in a large cohort of ambulatory persons with Parkinson's disease. PLOS One 2012;7, doi: 10.1371/annotation/d4b5158e-0dd1-4e14-b03a-1af4d5f06c0e.
10. Morris M, Iansek R, Matyas T, Summers J. Abnormalities in the stride length-cadence relation in parkinsonian gait. Mov Disord 1998;13:61-69.
11. Morris M, Iansek R, McGinley J, Matyas T, Huxham F. Three-dimensional gait biomechanics in Parkinson's disease: evidence for a centrally mediated amplitude regulation disorder. Mov Disord 2005;20:40-50.
12. Morris ME, Iansek R, Matyas TA, Summers JJ. Stride length regulation in Parkinson's disease: normalization strategies and underlying mechanisms. Brain 1996;119:551-568.
13. Alves G, Larsen JP, Emre M, Wentzel-Larsen T, Aarsland D. Changes in motor subtype and risk for incident dementia in Parkinson's disease. Mov Disord 2006;21:1123-1130.
14. Bohnen NI, Frey KA, Studenski S, et al. Gait speed in Parkinson disease correlates with cholinergic degeneration. Neurology 2013;81:1611-1616.
15. Burn DJ, Rowan EN, Allan LM, Molloy S, O'Brien JT, McKeith IG. Motor subtype and cognitive decline in Parkinson's disease, Parkinson's disease with dementia, and dementia with Lewy bodies. J Neurol Neurosurg Psychiatry 2006;77:585-589.
16. Lord S, Galna B, Coleman S, Burn D, Rochester L. Mild depressive symptoms are associated with gait impairment in early Parkinson's disease. Mov Disord 2013;28:634-639.
17. Rochester L, Yarnall AJ, Baker MR, et al. Cholinergic dysfunction contributes to gait disturbance in early Parkinson's disease. Brain 2012;135:2779-2788.
18. Lord S, Galna B, Rochester L. Moving forward on gait measurement: towards a more refined approach. Mov Disord 2013;28:1534-1543.
19. Galna B, Newman J, Jakovljevic DG, et al. Discrete gait characteristics are associated with m.3243A>G and m.8344A>G variants of mitochondrial disease and its pathological consequences. J Neurol 2014;261:73-82.
20. Rochester L, Galna B, Lord S, Mhiripiri D, Eglon G, Chinnery PF. Gait impairment precedes clinical symptoms in spinocerebellar ataxia type 6. Mov Disord 2014;29:252-255.
21. Khoo T, Yarnall A, Duncan G, et al. The spectrum of non-motor symptoms in early Parkinson's disease. Neurology 2012;79:1-7.
22. Yarnall AJ, Breen DP, Duncan GW, et al. Characterizing mild cognitive impairment in incident Parkinson disease: the ICICLE-PD study. Neurology 2014;82:308-316.
23. Gibb WR, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1988;51:745-752.
24. Folstein M, Folstein S, McHugh P. Mini-mental state: a practical method for grading the congitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
25. Litvan I, Bhatia KP, Burn DJ, et al. SIC task force appraisal of clinical diagnostic criteria for parkinsonian disorders. Mov Disord 2003;18:467-486.
26. Lord S, Galna B, Verghese J, Coleman S, Burn D, Rochester L. Independent domains of gait in older adults and associated motor and nonmotor attributes: validation of a factor analysis approach. J Gerontol A Biol Sci Med Sci 2012;68:820-827.
27. Galna B, Lord S, Rochester L. Is gait variability reliable in older adults and Parkinson's disease? Towards an optimal testing protocol. Gait Posture 2012;37:580-585.
28. Goetz C, Poewe W, Rascol O, et al. Movement Disorder Society Task Force Report on the Hoehn and Yahr Staging Scale: status and recommendations. Mov Disord 2004;19:1020-1028.
29. Goetz CG, Fahn S, Martinez-Martin P, et al. Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): process, format, and clinimetric testing plan. Mov Disord 2007;22:41-47.
30. Podsiadlo D, Richarson S. The time "Up & Go": a test of basic functional mobiltiy for frail elderly persons. J Am Geriatr Soc 1991;39:142-148.
31. Powell LE, Myers AM. The Activities-specific Balance Confidence (ABC) scale. J Gerontol A Biol Sci Med Sci 1995;50A:M28-M34.
32. Schrag A, Barone P, Brown RG, et al. Depression rating scales in Parkinson's disease: critique and recommendations. Mov Disord 2007;22:1077-1092.
33. Smets EM, Garssen B, Bonke B, De Haes JC. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res 1995;39:315-325.
34. Stebbins GT, Goetz CG, Burn DJ, Jankovic J, Khoo TK, Tilley BC. How to identify tremor dominant and postural instability/gait difficulty groups with the movement disorder society unified Parkinson's disease rating scale: comparison with the unified Parkinson's disease rating scale. Mov Disord 2013;28:668-670.
35. Tomlinson CL, Stowe R, Patel S, Rick C, Gray R, Clarke CE. Systematic review of levodopa dose equivalency reporting in Parkinson's disease. Mov Disord 2010;25:2649-2653.
36. Baltadjieva R, Giladi N, Gruendlinger L, Peretz C, Hausdorff JM. Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson's disease. Eur J Neurosci 2006;24:1815-1820.
37. Carpinella I, Crenna P, Calabrese E, et al. Locomotor function in the early stage of Parkinson's disease. IEEE T Neur Sys Reh 2007;15:543-551.
38. Yogev G, Plotnik M, Peretz C, Giladi N, Hausdorff JM. Gait asymmetry in patients with Parkinson's disease and elderly fallers: when does the bilateral coordination of gait require attention? Exp Brain Res 2007;177:336-346.
39. Brach JS, Berlin J, VanSwearingen J, Newman A, Studenski S. Too much or too little step width variability is associated with a fall history only in older persons who walk at or near normal gait speed. J Am Geriatr Soc 2005;53:S133-S134.
40. Rochester L, Galna B, Lord S, Burn D. The nature of dual-task interference during gait in incident Parkinson's disease. Neuroscience 2014;265C:83-94.
41. Horak FB, Frank J, Nutt J. Effects of dopamine on postural control in Parkinsonian subjects: scaling, set, and tone. J Neurophysiol 1996;75:2380-2396.
42. Rocchi L, Chiari L, Horak FB. Effects of deep brain stimulation and levodopa on postural sway in Parkinson's disease. J Neurol Neurosur Psychiatry 2002;73:267-274.
43. Jankovic J, McDermott M, Carter J, et al. Variable expression of Parkinson's disease: a base-line analysis of the DATATOP cohort. The Parkinson Study Group. Neurology 1990;40:1529-1534.
44. van Rooden SM, Heiser WJ, Kok JN, Verbaan D, van Hilten JJ, Marinus J. The identification of Parkinson's disease subtypes using cluster analysis: a systematic review. Mov Disord 2010;25:969-978.
45. Thenganatt MA, Jankovic J. Parkinson disease subtypes. JAMA Neurol 2014;71:499-504.