Cbfb deficiency results in differentiation blocks and stem/progenitor cell expansion in hematopoiesis

Leukemia

Volumn 29, Issue 3, 2015, Pages 753-757

  Wang, C Q ^a,b   Chin, D W L ^a   Chooi, J Y ^a   Chng, W J ^a   Taniuchi, I ^c   Tergaonkar, V ^b   Osato, M ^a,d,e,f  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^c Institute of Physical and Chemical Research   (Japan)

^d INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; IMMUNOGLOBULIN D; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CBFB; TRANSCRIPTION FACTOR GATA 2; UNCLASSIFIED DRUG; CBFB PROTEIN, MOUSE; CORE BINDING FACTOR BETA; LEUKOCYTE ANTIGEN;

ALLELE; B LYMPHOCYTE; BACTERIAL INFECTION; BLOOD CELL COUNT; BONE MARROW; BONE MARROW TRANSPLANTATION; CBFB DEFICIENCY; CELL DIFFERENTIATION; CELL EXPANSION; CELL LINEAGE; CHIMERA; COLONY FORMING UNIT GM; DNA BINDING; ENGRAFTMENT; ERYTHROBLAST; EXTRAMEDULLARY HEMATOPOIESIS; FLOW CYTOMETRY; GRANULOCYTE; GRANULOCYTE PRECURSOR; HEMATOPOIESIS; HUMAN; LETHALITY; LETTER; LEUKOCYTE; LYMPHOID PROGENITOR CELL; MEGAKARYOBLAST; MEGAKARYOCYTE; MEGAKARYOCYTE ERYTHROID PROGENITOR; MYELOID PROGENITOR CELL; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PANCYTOPENIA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SPLEEN WEIGHT; STEM CELL; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THYMUS; ANIMAL; CELL PROLIFERATION; DEFICIENCY; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MORTALITY; MOUSE; PATHOLOGY; SURVIVAL; THROMBOCYTE;

ANIMALS; ANTIGENS, CD; BLOOD PLATELETS; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CORE BINDING FACTOR BETA SUBUNIT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEMATOPOIESIS; HEMOGLOBINS; HUMANS; LEUKOCYTES; MICE; MICE, KNOCKOUT; PANCYTOPENIA; PLATELET COUNT; STEM CELLS; SURVIVAL ANALYSIS;

EID: 84924533058     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2014.316     Document Type: Letter

References (15)

1. Wang Q, Stacy T, Miller JD, Lewis AF, Gu TL, Huang X et al. The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell 1996; 87: 697-708.
2. Jacob B, Osato M, Yamashita N, Wang CQ, Taniuchi I, Littman DR et al. Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis. Blood 2010; 115: 1610-1620.
3. Growney JD, Shigematsu H, Li Z, Lee BH, Adelsperger J, Rowan R et al. Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood 2005; 106: 494-504.
4. Taniuchi I, Osato M, Egawa T, Sunshine MJ, Bae SC, Komori T et al. Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 2002; 111: 621-633.
5. Osato M. Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia. Oncogene 2004; 23: 4284-4296.
6. Speck NA, Gilliland DG. Core-binding factors in haematopoiesis and leukaemia. Nat Rev Cancer 2002; 2: 502-513.
7. Ley TJ, Miller C, Ding L, Raphael BJ, Mungall AJ, Robertson AG et al. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013; 368: 2059-2074.
8. Liu P, Tarle SA, Hajra A, Claxton DF, Marlton P, Freedman M et al. Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science 1993; 261: 1041-1044.
9. Castilla LH, Wijmenga C, Wang Q, Stacy T, Speck NA, Eckhaus M et al. Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11. Cell 1996; 87: 687-696.
10. Chen MJ, Yokomizo T, Zeigler BM, Dzierzak E, Speck NA. Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature 2009; 457: 887-891.
11. Wang CQ, Motoda L, Satake M, Ito Y, Taniuchi I, Tergaonkar V et al. Runx3 deficiency results in myeloproliferative disorder in aged mice. Blood 2013; 122: 562-566.
12. Kuo YH, Landrette SF, Heilman SA, Perrat PN, Garrett L, Liu PP et al. Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia. Cancer Cell 2006; 9: 57-68.
13. Hyde RK, Kamikubo Y, Anderson S, Kirby M, Alemu L, Zhao L et al. Cbfb/Runx1 repression-independent blockage of differentiation and accumulation of Csf2rb-expressing cells by Cbfb-MYH11. Blood 2010; 115: 1433-1443.
14. de Pater E, Kaimakis P, Vink CS, Yokomizo T, Yamada-Inagawa T, van der Linden R et al. Gata2 is required for HSC generation and survival. J Exp Med 2013; 210: 2843-2850.
15. Mrozek K, Marcucci G, Nicolet D, Maharry KS, Becker H, Whitman SP et al. Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia. J Clin Oncol 2012; 30: 4515-4523.